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With N-Bromosuccinimide for 16h; Reflux; Irradiation;
168 Example 149
General procedure: Synthesis of 4-bromo-7-(bromomethyl)benzo[c][1,2,5]thiadiazole (149A): To a stirred solution of 4-bromo-7-methylbenzo[c][1,2,5]thiadiazole (1.00 g, 4.37 mmol) in benzene (11 ml_) was added NBS (0.932 g, 5.24 mmol) at RT. The reaction mixture was heated to reflux under tungsten light for 16 h. The reaction was cooled to RT, filtered, and concentrated to yield 149A.