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Chemical Structure| 1548-81-8 Chemical Structure| 1548-81-8

Structure of 2-Bromo-6-fluorobenzyl bromide
CAS No.: 1548-81-8

Chemical Structure| 1548-81-8

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Product Details of [ 1548-81-8 ]

CAS No. :1548-81-8
Formula : C7H5Br2F
M.W : 267.92
SMILES Code : FC1=C(CBr)C(Br)=CC=C1
MDL No. :MFCD10698675
InChI Key :YCICURIWHWLGTN-UHFFFAOYSA-N
Pubchem ID :24820209

Safety of [ 1548-81-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 1548-81-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1548-81-8 ]

[ 1548-81-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 261723-33-5 ]
  • [ 1548-81-8 ]
YieldReaction ConditionsOperation in experiment
83% With pyridine; phosphorus tribromide; In chloroform; at 0 - 20℃; PREPARATION 8 1-Bromo-3-fluorobenzyl bromide To a solution of <strong>[261723-33-5]1-bromo-3-fluorobenzyl alcohol</strong> (1.61 kg, 7.85 mol) in chloroform (14 L) at 0° C. add pyridine (770 mL, 9.52 mol) in one portion (slight exotherm) and stir at 0° C. for 5 min. Add phosphorus tribromide (900 mL, 9.49) dropwise while maintaining the internal temperature below 20° C. and stir the resulting solution overnight while allowing to warm to room temperature. Cool the reaction to 0° C. and quench slowly with ice water (2 L). Transfer to a 50 L flask, separate the layers and then extract the aqueous layer with chloroform (1 L). Wash the combined organic phases with 5percent sulfuric acid (2 L), saturated aqueous sodium bicarbonate (2 L), brine (2 L), dry over magnesium sulfate, filter, and concentrate to obtain the title compound as a yellow oil (1753 g, 83percent). 1H NMR (CDCl3) delta 7.43 (d, 1H), 7.21 (m, 1H), 7.09 (t, 1H), 4.68 (s, 2H).
 

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