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Chemical Structure| 155705-46-7 Chemical Structure| 155705-46-7

Structure of 155705-46-7

Chemical Structure| 155705-46-7

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Product Details of [ 155705-46-7 ]

CAS No. :155705-46-7
Formula : C6H5ClFN
M.W : 145.56
SMILES Code : FC1=NC=CC(CCl)=C1
MDL No. :MFCD10697553

Safety of [ 155705-46-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 155705-46-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 155705-46-7 ]

[ 155705-46-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 436-77-1 ]
  • [ 155705-46-7 ]
  • C55H54F3N5O6(2+)*2Cl(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
9.54g With sodium ethanolate; In N,N-dimethyl-formamide; at 70℃; for 2h; Weighing 6.10g of <strong>[436-77-1]fangchinoline</strong>base,0.10 g of sodium ethoxide dissolved in DMF 100 mL in a 500 mL three-necked flask,Then add 5.20g of 2-fluoro-4-pyridylmethyl chloride, stir and mix well, heat at 70 C for 2h, TLC detection of all reactions of <strong>[436-77-1]fangchinoline</strong>,DMF was evaporated under reduced pressure, 200 g silica gel H column chromatography, eluting with ethyl acetate-ethanol (10:1).TLC tracks the separation and purification process of the reaction and product, collects and combines product fractions,The solvent was distilled off at 60 C using a rotary evaporator.That is, 9.54 g of a product as a pale yellow powder. The desired product has the melting point: 209.4-210.9 C, 13C NMR (CDCl3, 100 MHz) delta 162.91, 160.41, 153.98,151.84, 151.46, 151.23, 149.64, 148.86, 148.76, 148.65, 148.55, 148.43, 147.29, 143.84,136.36, 135.34, 133.85, 133.74, 133.42, 130.41, 128.87, 128.64, 128.44, 128.19, 127.83,127.49, 126.63, 126.29, 117.68, 122.15, 120.36, 116.50, 116.50, 116.26, 115.42, 115.29,113.13, 111.76, 106.11, 66.85, 64.24, 61.65, 56.35, 56.20, 56.04, 55.88, 55.67, 45.98,45.57, 44.33, 42.60, 42.32, 42.08, 39.98, 24.74. TOF-HRMS: M/e (1008.9414), molecular formula:C55H54O6N5F3Cl2,That is, compound III54.
 

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