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Chemical Structure| 1562519-39-4 Chemical Structure| 1562519-39-4

Structure of 1562519-39-4

Chemical Structure| 1562519-39-4

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Product Details of [ 1562519-39-4 ]

CAS No. :1562519-39-4
Formula : C20H19ClN2O3
M.W : 370.83
SMILES Code : O=C(NC1=C2C=CC=CC2=C(C=C1)OC3=CC(Cl)=NC=C3)OC(C)(C)C
MDL No. :MFCD31556240

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Application In Synthesis of [ 1562519-39-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1562519-39-4 ]

[ 1562519-39-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 62606-02-4 ]
  • [ 1562519-39-4 ]
  • tert-butyl (4-((2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)pyridin-4-yl)oxy)naphthalen-1-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
698 mg With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; In tert-butyl alcohol; at 85℃; for 16h;Inert atmosphere; (i) tert-Butyl (4-((2-((3-methoxy-5-(methylsulfonyl)phenvnamino)pyridin-4-vnoxy)naphthalen-1-yl)carbamateA mixture of <strong>[62606-02-4]3-methoxy-5-(methylsulfonyl)aniline</strong> (Casillas, L. N. et al., WO 2011/120026, 29 Sep 201 1 ; 300 mg, 1.491 mmol), tert-butyl (4-((2-chloropyridin-4-yl)oxy)naphthalen-1- yl)carbamate (see Example 2(ii) above; 553 mg, 1.491 mmol), K2CO3 (412 mg, 2.98 mmol) and BrettPhos G1 precatalyst (23.82 mg, 0.030 mmol) were degassed under vacuum, back filling with nitrogen 3 times. tBuOH (3 ml.) was added and the suspension degassed an additional 3 times. The reaction was heated under nitrogen at 85C for 16 hours. The reaction mixture was diluted with DCM (20 ml_), filtered through celite and concentrated in vacuo. The crude product was purified by chromatography on the Companion (12 g column, 0-100% ethyl acetate in iso-hexane) to afford the sub-title compound (698 mg) as a thick yellow gum. LCMS m/z 536 (M+H)+(ES+); 534 (M-H)"(ES")
 

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