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[ CAS No. 156276-21-0 ] {[proInfo.proName]}

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Chemical Structure| 156276-21-0
Chemical Structure| 156276-21-0
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Product Details of [ 156276-21-0 ]

CAS No. :156276-21-0 MDL No. :MFCD09833003
Formula : C9H9ClO3 Boiling Point : -
Linear Structure Formula :- InChI Key :ZMPGBVQQIQSQED-UHFFFAOYSA-N
M.W : 200.62 Pubchem ID :11321601
Synonyms :

Safety of [ 156276-21-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 156276-21-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 156276-21-0 ]
  • Downstream synthetic route of [ 156276-21-0 ]

[ 156276-21-0 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 156276-21-0 ]
  • [ 85259-19-4 ]
YieldReaction ConditionsOperation in experiment
56% With phosphorus tribromide In chloroform at 20℃; for 96 h; General procedure: Methyl 2-hydroxy-2-phenylacetate 7a (5.00 g, 30 mmol) was dissolved in CHCl3 (50 ml) and 2 equivalents of PBr3 (8.09 ml, 60 mmol). This was then stirred at r.t. for 4 days. Upon completion the reaction was washed with water (50 ml), dried (MgSO4) and then passed through a silica pad. The CHCl3 was removed to give the title compound as a clear oil, 5.00 g (26 mmol, 75percent).
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 6, p. 1106 - 1110
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 5, p. 900 - 910
  • 2
  • [ 156276-21-0 ]
  • [ 90055-47-3 ]
Reference: [1] Synthesis, 2008, # 24, p. 4007 - 4011
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 34, p. 10145 - 10149[3] Angew. Chem., 2016, vol. 128, # 34, p. 10300 - 10304,5
[4] Patent: WO2016/202894, 2016, A1, . Location in patent: Page/Page column 56; 150; 159; 160
[5] Patent: WO2007/126258, 2007, A1, . Location in patent: Page/Page column 5
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