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Chemical Structure| 1569-15-9 Chemical Structure| 1569-15-9

Structure of 1569-15-9

Chemical Structure| 1569-15-9

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Product Details of [ 1569-15-9 ]

CAS No. :1569-15-9
Formula : C9H9N3O
M.W : 175.19
SMILES Code : O=C1NC2=C(C=CC(N)=N2)C(C)=C1
MDL No. :MFCD00744825

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Application In Synthesis of [ 1569-15-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1569-15-9 ]

[ 1569-15-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 39539-66-7 ]
  • 6-(2-chloro-4-methyl-1,8-naphthyridin-7-vl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole [ No CAS ]
  • 6-(2-chloro-4-methyl-1,8-naphthyridin-7-yl)-5-hydroxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole [ No CAS ]
  • [ 1569-15-9 ]
YieldReaction ConditionsOperation in experiment
In N-methyl-acetamide; ice-water; EXAMPLE 19 Following the procedure of Example 17 but starting with 6-(2-chloro-4-methyl-1,8-naphthyridin-7-yl)-5-hydroxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole (16.7 g.), sodium hydride (1.65 g.) and 1-chlorocarbonyl-4-methylpiperazine (22.0 g.) in anhydrous dimethylformamide (280 cc.) stirring the reaction mixture for 4 hours at 5 C. and then diluting it with ice-water (2,800 cc.), 6-(2-chloro-4-methyl-1,8-naphthyridin-7-vl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole (11.7 g.), melting at 233 C. after recrystallisation from acetonitrile, is obtained. 6-(2-Chloro-4-methyl-1,8-naphthyridin-7-yl)-5-hydroxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole employed as starting material can be obtained in the following way: Preparation of 7-amino-2-hydroxy-4-methyl-1,8-naphthyridine, m.p. above 400 C., according to O. Seide, Chem. Ber., 59, 2465 (1926).
 

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