Alternatived Products of [ 156901-61-0 ]
Product Details of [ 156901-61-0 ]
CAS No. : | 156901-61-0 |
MDL No. : | MFCD07528158 |
Formula : |
C9H7N3O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
189.17
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 156901-61-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 156901-61-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 156901-61-0 ]
- 1
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[ 607-32-9 ]
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[ 156901-61-0 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydroxide; hydroxylamine hydrochloride; In methanol; ethanol; at 50℃; for 1.5h; |
Example 134 N-(8-aminoisoquinolin-5-yl)-N'-[2-(3,5-difluorophenoxy)-1-methylethyl]urea 2 TFA salt Step 1: 8-amino-<strong>[607-32-9]5-nitroisoquinoline</strong>; To <strong>[607-32-9]5-nitroisoquinoline</strong> (2.0 g) were added hydroxylamine hydrochloride (5.0 g) and ethanol (120 ml). A solution of sodium hydroxide (10 g) in methanol (65 ml) was slowly added at 50C over 90 min. The reaction mixture was poured into ice water (700 g) and the resulting precipitate was collected by filtration. The residue was washed with ethanol and dried under reduced pressure to give 8-amino-<strong>[607-32-9]5-nitroisoquinoline</strong> (1.25 g). |
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With potassium hydroxide; hydroxylamine; In ethanol; |
Amination of <strong>[607-32-9]5-nitro-isoquinoline</strong> 1 with hydroxylamine and KOH in ethanol provides 5-nitro-8-aminoisoquinoline 2. Catalytic hydrogenation of 2 with hydrogen/Pd-C affords 5,8-diaminoisoquinoline 3 (Bioorg. Med. Chem. Lett. 1999, 1075). Treatment of 3 with acetic anhydride gives compound 4, which, on treatment with peracetic acid, results in the formation of the N-oxide 5. Hydrolysis of 5 with 6N-HCl affords compound 6. |
Reference:
[1]ChemMedChem,2011,vol. 6,p. 1872 - 1883
[2]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1075 - 1080
[3]Medicinal Chemistry Research,2000,vol. 10,p. 40 - 49
[4]Patent: EP1679296,2006,A1 .Location in patent: Page/Page column 37
[5]Patent: US2006/156485,2006,A1 .Location in patent: Page/Page column 10
- 2
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[ 34784-07-1 ]
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[ 156901-61-0 ]