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Chemical Structure| 15721-22-9 Chemical Structure| 15721-22-9

Structure of 15721-22-9

Chemical Structure| 15721-22-9

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Product Details of [ 15721-22-9 ]

CAS No. :15721-22-9
Formula : C7H13ClO
M.W : 148.63
SMILES Code : CCCC(C)(C)C(Cl)=O

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Application In Synthesis of [ 15721-22-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15721-22-9 ]

[ 15721-22-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15721-22-9 ]
  • [ 24424-99-5 ]
  • [ 51304-61-1 ]
  • [ 138647-50-4 ]
YieldReaction ConditionsOperation in experiment
93% With triethylamine; In dichloromethane; Step 1 To a suspension of 4-(4-chloro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (5 g, 21.8 mmol) in methylene chloride (100 mL) was added triethylamine (3.6 g, 4.9 mL, 35 mmol). The resulting solution was cooled to 0 C. in an ice-water bath. Di-tert-butyl-dicarbonate (5.4 g, 25 mmol) was added and the resulting reaction was allowed to warm to rt and stir over night. The mixture was poured into 100 mL of a 1:11 N HCl:brine solution and diluted with methylene chloride (300 mL). The organic phase was washed with saturated aqueous sodium bicarbonate and brine, dried over magnesium sulfate, filtered and concentrated to afford 4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (6.68 g, 93%) as a colorless oil, which was used without further purification. 1H-NMR (CDCl3, 300 MHz) δ: 1.48 (s, 9H), 2.45-2.55 (m, 2H), 3.63 (t, 2H), 4.07 (q, 2H), 6.03 (br s, 1H), 7.29 (m, 4H).
 

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