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[ CAS No. 157368-82-6 ]

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Chemical Structure| 157368-82-6
Chemical Structure| 157368-82-6
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Product Details of [ 157368-82-6 ]

CAS No. :157368-82-6 MDL No. :MFCD18801052
Formula : C8H8N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :164.16 g/mol Pubchem ID :-
Synonyms :

Safety of [ 157368-82-6 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 157368-82-6 ]

  • Downstream synthetic route of [ 157368-82-6 ]

[ 157368-82-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 546-88-3 ]
  • [ 38469-83-9 ]
  • [ 157368-82-6 ]
  • 2
  • [ 38469-83-9 ]
  • [ 157368-82-6 ]
YieldReaction ConditionsOperation in experiment
72% With acetylhydroxamic acid; potassium tert-butylate; In N,N-dimethyl-formamide; at 20℃; for 16h; To a solution of N-hydroxyacetamide (3.2 g, 42 mmol) in dry N,N-dimethylformamide (50 mL ) at room temperature was added potassium 7-butoxide (6.6 g, 59 mmol). After stirring for 30 minutes, <strong>[38469-83-9]4-methoxy-2-nitrobenzonitrile</strong> (3.0 g, 17 mmol) was added, and stirring was continued for another 16 hours. On completion, the reaction mixture was quenched with water and extracted with ethyl acetate (3 100 mL). The combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate, concentrated in vacuo and purified by silica gel chromatography [petroleum ether: ethyl acetate = 1: 1] to give compound A-5 (2.0 g, 72% yield) as a yellow solid. LCMS (J): (ES+) m/z (M+H)+ = 165.1, tR= 1.164 min.
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