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Chemical Structure| 157590-69-7 Chemical Structure| 157590-69-7

Structure of 157590-69-7

Chemical Structure| 157590-69-7

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Product Details of [ 157590-69-7 ]

CAS No. :157590-69-7
Formula : C7H4F3N3O
M.W : 203.12
SMILES Code : FC(F)(F)OC1=CC=C(NN=N2)C2=C1
MDL No. :MFCD08669485

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Application In Synthesis of [ 157590-69-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 157590-69-7 ]

[ 157590-69-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2267-23-4 ]
  • [ 157590-69-7 ]
YieldReaction ConditionsOperation in experiment
74% a. A mixture of 2-nitro-4-trifluoromethylaniline (12 g) and activated palladium on charcoal (0.6 g) in methanol was hydrogenated with one atmosphere of hydrogen under stirring at room temperature for one hour. The reaction mixture was filtered through a pad of diatomaceous earth and the filtrate concentrated under reduced pressure to give a residue. This residue was then dissolved in acetic acid (100 mL) and water (15 mL) and cooled to 0 C. prior to adding hydrochloric acid (4 mL) and a solution of sodium nitrite (4.4 g) in water (10 mL). The mixture was stirred at room temperature for two hours and then diluted with water. The resulting solid was filtered, washed with water and dried to obtain an off-white solid (8.0 g, 73%).
 

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