[ CAS No. 15774-06-8 ] {[proInfo.proName]}

Name: 15774-06-8|2-(1H-Indol-3-yl)ethane-1-thiol|95%
Brand: Ambeed
SKU: A1082784
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Quality Control of [ 15774-06-8 ]

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Product Details of [ 15774-06-8 ]

CAS No. :	15774-06-8	MDL No. :	MFCD20661296
Formula :	C₁₀H₁₁NS	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CLQAPWVEHNTJLC-UHFFFAOYSA-N
M.W :	177.27	Pubchem ID :	12244279
Synonyms :

Safety of [ 15774-06-8 ]

Signal Word:	Danger	Class:	9
Precautionary Statements:	P264-P270-P280-P305+P351+P338-P310-P330-P403-P501	UN#:	3077
Hazard Statements:	H302-H318-H411	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 15774-06-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 15774-06-8 ]

[ 15774-06-8 ] Synthesis Path-Downstream 1~22

1
[ 105-45-3 ]
[ 15774-06-8 ]
[ 41339-53-1 ]

Yield	Reaction Conditions	Operation in experiment
	With toluene-4-sulfonic acid In benzene

Reference： [1]Jirkovsky,I. et al. [Journal of Heterocyclic Chemistry, 1975, vol. 12, p. 937 - 940]

2
[ 3249-68-1 ]
[ 15774-06-8 ]
[ 42819-74-9 ]

Yield	Reaction Conditions	Operation in experiment
	With toluene-4-sulfonic acid In benzene

Reference： [1]Jirkovsky,I. et al. [Journal of Heterocyclic Chemistry, 1975, vol. 12, p. 937 - 940]

3
[ 15774-06-8 ]
[ 623-47-2 ]
(1,3,4,9-tetrahydro-thiopyrano[3,4-<i>b</i>]indol-1-yl)-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate In methanol

Reference： [1]Jirkovsky,I. et al. [Journal of Heterocyclic Chemistry, 1975, vol. 12, p. 937 - 940]

4
[ 15774-06-8 ]
[ 4949-44-4 ]
[ 42819-73-8 ]

Yield	Reaction Conditions	Operation in experiment
	With toluene-4-sulfonic acid In benzene

Reference： [1]Jirkovsky,I. et al. [Journal of Heterocyclic Chemistry, 1975, vol. 12, p. 937 - 940]

Yield	Reaction Conditions	Operation in experiment
	Rk. m. Acetessigsaeure-methylester Bildung (IIa);
	Rk. m. Ethyl-β-oxovaleriat Bildung (IIb);
	Rk. m. Ethyl-β-oxocapronat Bildung (IIc);

Rk. m. Ethyl-propiolat Bildung (IId) od. (XIII);

Yield	Reaction Conditions	Operation in experiment
	Thiosulfat (VIII), H3PO4;
	Indol, Thiiran;
	Disulfid (IV), LiAlH4;

3.2 g (100%)

2-(1H-Indol-3-yl)-ethanethiol 2-(1H-Indol-3-yl)-ethanethiol Thiosulfuric acid S-[2-(1H-indol-3-yl)-ethyl]ester, O-sodium salt (5.04 g, 18 mmol) was suspended in 105 ml of 50% phosphoric acid and covered with a layer of 160 ml of ether. The mixture was refluxed for 6 hours. After cooling, the phases were separated and the aqueous phase was extracted with ether and the organic phases were concentrated to dryness by evaporation. The crude product was obtained in a yield of 3.2 g (100%).

7
[ 15774-06-8 ]
[ 58264-55-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: TsOH / benzene 2: (i) NaH, benzene, DMF, (ii) /BRN= 1209223/

Reference： [1]Jirkovsky,I. et al. [Journal of Heterocyclic Chemistry, 1975, vol. 12, p. 937 - 940]

8
[ 863514-54-9 ]
[ 75-75-2 ]
[ 15774-06-8 ]
1,1-(3-dimethylamino-3-(3-fluorophenyl)-pentamethylen)-1,3,4,9-tetrahydro-2-thia-9-azafluorene methansulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane at 20℃; for 18h;

Reference： [1]Current Patent Assignee: PARK THERAPEUTICS INC - WO2004/43967, 2004, A1 Location in patent: Page/Page column 55

9
[ 10090-05-8 ]
[ 65618-76-0 ]
[ 15774-06-8 ]
1,1-(3-dimethylamino-3-(4-fluorophenyl)-pentamethylen)-1,3,4,9-tetrahydro-2-thia-9-azafluorene methansulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane at 20℃; for 92h;

Reference： [1]Current Patent Assignee: PARK THERAPEUTICS INC - WO2004/43967, 2004, A1 Location in patent: Page/Page column 54-55

10
[ 65619-20-7 ]
[ 15774-06-8 ]
4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-thiopyrano[3,4-b]-indol]-4-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With phosphoric acid; acetic acid In water at 4 - 20℃; for 20h;
	Stage #1: 4-dimethylamino-4-phenylcyclohexanone; 2-(1H-indol-3-yl)ethane-1-thiol With trimethylsilyl methanesulfonate In dichloromethane at 20℃; for 96h; Stage #2: With sodium hydroxide In ethanol; dichloromethane; water at 20℃; for 1.5h; Heating / reflux;

Reference： [1]Current Patent Assignee: PARK THERAPEUTICS INC - WO2004/43967, 2004, A1 Location in patent: Page/Page column 30
[2]Current Patent Assignee: PARK THERAPEUTICS INC - WO2004/43967, 2004, A1 Location in patent: Page/Page column 29-30

11
[ 10090-05-8 ]
[ 65619-20-7 ]
[ 15774-06-8 ]
1,1-(3-dimethylamino-3-phenylpentamethylene)-1,3,4,9-tetrahydro-2-thia-9-azafluoren methanesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane at 20℃; for 96h;

Reference： [1]Current Patent Assignee: PARK THERAPEUTICS INC - WO2004/43967, 2004, A1 Location in patent: Page/Page column 29-30

12
[ 876932-36-4 ]
[ 15774-06-8 ]
1,1-(2-(dimethylaminomethyl)-3-hydroxy-3-(3-fluorophenyl)-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%	Stage #1: 3-dimethylaminomethyl-4-(3-fluorophenyl)-4-hydroxy-cyclohexanone; 2-(1H-indol-3-yl)ethane-1-thiol With phosphoric acid; acetic acid at 20℃; for 24h; Stage #2: With sodium hydroxide In water
	With sodium hydroxide; phosphoric acid In dichloromethane; acetic acid	13 1,1-(2-(Dimethylaminomethyl)-3-hydroxy-3-(3-fluorophenyl)-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene 1,1-(2-(Dimethylaminomethyl)-3-hydroxy-3-(3-fluorophenyl)-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene 3-Dimethylaminomethyl-4-(3-fluorophenyl)-4-hydroxy-cyclohexanone (1.0 g, 3.8 mmol) and 2-(1H-indol-3-yl)-ethanethiol (670 mg, 3.8 mmol) were dissolved in 17 ml of glacial acetic acid. 4 ml of phosphoric acid were added dropwise at 5° C., and stirring was carried out for 24 hours at RT. 130 ml of 1M sodium hydroxide solution and 100 ml of dichloromethane were added at 5° C., and stirring was carried out for 2 hours at RT. The phases were separated and the aqueous phase was extracted with dichloromethane. After concentration of the solvent, 839 mg (52%) of the crude product were obtained.

Reference： [1]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - WO2006/18184, 2006, A2 Location in patent: Page/Page column 29-30
[2]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - US2007/213351, 2007, A1

13
[ 877033-67-5 ]
[ 15774-06-8 ]
1,1-(2-(dimethylaminomethyl)-3-hydroxy-3-phenyl-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	Stage #1: 3-dimethylaminomethyl-4-phenyl-4-hydroxy-cyclohexanone; 2-(1H-indol-3-yl)ethane-1-thiol With phosphoric acid; acetic acid at 20℃; for 24h; Stage #2: With sodium hydroxide In water
	With sodium hydroxide; phosphoric acid In dichloromethane; acetic acid	8 1,1-(2-(Dimethylaminomethyl)-3-hydroxy-3-phenyl-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene 1,1-(2-(Dimethylaminomethyl)-3-hydroxy-3-phenyl-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene 3-Dimethylaminomethyl-4-phenyl-4-hydroxy-cyclohexanone (1.4 g, 5.7 mmol) and 2-(1H-indol-3-yl)-ethanethiol (1.0 g, 5.7 mmol) were dissolved in 26 ml of glacial acetic acid. 6 ml of phosphoric acid were added dropwise at about 10° C., and stirring was carried out for 24 hours at RT. 190 ml of 1M sodium hydroxide solution and 150 ml of dichloromethane were added at 0° C., and stirring was carried out for 30 minutes at RT. The phases were separated and the aqueous phase was extracted with dichloromethane. After concentration of the solvent, 1.35 g (59%) of the crude product were obtained.

Reference： [1]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - WO2006/18184, 2006, A2 Location in patent: Page/Page column 27
[2]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - US2007/213351, 2007, A1

14
[ 876932-39-7 ]
[ 15774-06-8 ]
1,1-(2-(dimethylaminomethyl)-3-hydroxy-3-(2-methylphenyl)-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
35%	Stage #1: 3-dimethylaminomethyl-4-(2-methylphenyl)-4-hydroxy-cyclohexanone; 2-(1H-indol-3-yl)ethane-1-thiol With phosphoric acid; acetic acid at 20℃; for 20h; Stage #2: With sodium hydroxide In water at 5℃; for 1h;
541 mg (35%)	With phosphoric acid In dichloromethane; acetic acid	23 1,1-(2-(Dimethylaminomethyl)-3-hydroxy-3-(2-methylphenyl)-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene 1,1-(2-(Dimethylaminomethyl)-3-hydroxy-3-(2-methylphenyl)-pentamethylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene 3-Dimethylaminomethyl-4-(2-methylphenyl)-4-hydroxy-cyclohexanone (980 mg, 3.7 mmol) and 2-(1H-indol-3-yl)-ethanethiol (660 mg, 3.7 mmol) were dissolved in 17 ml of glacial acetic acid. 4 ml of 85% phosphoric acid were added dropwise at 5° C., and stirring was carried out for 20 hours at RT. 100 ml of dichloromethane were added at 5° C., the pH was adjusted to 9 with 5M sodium hydroxide solution, and then stirring was carried out for one hour. The phases were separated and the aqueous phase was extracted with dichloromethane. After removal of the solvent by distillation, the crude product was obtained in a yield of 541 mg (35%).

Reference： [1]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - WO2006/18184, 2006, A2 Location in patent: Page/Page column 35
[2]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - US2007/213351, 2007, A1

15
[ 877033-73-3 ]
[ 15774-06-8 ]
1,1-(2-(dimethylaminomethyl)-3-hydroxy-3-(4-methylthiophenyl)-penta-methylene)-1,3,4,9-tetrahydro-2-thia-9-aza-fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	Stage #1: 3-dimethylaminomethyl-4-(4-methylthio-phenyl)-4-hydroxy-cyclohexanone; 2-(1H-indol-3-yl)ethane-1-thiol With phosphoric acid; acetic acid at 20℃; for 20h; Stage #2: With sodium hydroxide In water at 10℃; for 1h;

Reference： [1]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - WO2006/18184, 2006, A2 Location in patent: Page/Page column 34-35

16
[ 15849-64-6 ]
[ 15774-06-8 ]

Yield	Reaction Conditions	Operation in experiment
100%	With phosphoric acid In diethyl ether; water for 6h; Heating / reflux;

Reference： [1]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - WO2006/18184, 2006, A2 Location in patent: Page/Page column 22

17
aqueous alcoholic KOH [ No CAS ]
[ 105-45-3 ]
[ 15774-06-8 ]
[ 41339-53-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; toluene-4-sulfonic acid In water; benzene	3 1-METHYL-1,3,4,9-TETRAHYDROTHIOPYRANO[3,4-b]INDOLE-1-ACETIC ACID (I; R1 = CH3, R2, R3, R4, R5, R6 AND R7 = H, X = S, Y = CH2 CO AND Z = OH) EXAMPLE 3 1-METHYL-1,3,4,9-TETRAHYDROTHIOPYRANO[3,4-b]INDOLE-1-ACETIC ACID (I; R1 = CH3, R2, R3, R4, R5, R6 AND R7 = H, X = S, Y = CH2 CO AND Z = OH) Indole-3-ethanethiol (1.5 g.) and methyl acetoacetate are mixed with 50 ml. of benzene and the solution heated for 30 min. (bath temperature 70° - 80°C.). p-Toluenesulfonic acid (0.15 g.) is added and the reaction mixture is subjected to reflux and stirring for 12 hours. Water formed in the reaction mixture during this period is collected by a water separator. After cooling the benzene solution is washed with a 10% solution of sodium bicarbonate, water, saturated brine and dried over sodium sulfate. Evaporation of the benzene solution yields the ester, 1-methyl-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid methyl ester as a semi-solid, ννCHCl 3 1715 cm-1. This ester is then treated with aqueous alcoholic KOH in the manner described for the esters in Example 1 and 2 to afford the title compound, m.p. 147° - 149°C., nmr (CDCl3) δ1.86 (S, 3H), 3.06 and 8.12 (6H), 7.35 (multiplet, 4H), 8.71 (1H), 10.31 (1H), after recrystallization from benzene-hexane.
	With sodium hydrogencarbonate; toluene-4-sulfonic acid In water; benzene	3 1-Methyl-1,3,4,9-Tetrahydrothiopyrano[3,4-b]indole-1-Acetic Acid (I; R1 = CH3, R2, R3, R4, R5, R6 and R7 = H, X = S, Y = CH2 CO and Z = OH) EXAMPLE 3 1-Methyl-1,3,4,9-Tetrahydrothiopyrano[3,4-b]indole-1-Acetic Acid (I; R1 = CH3, R2, R3, R4, R5, R6 and R7 = H, X = S, Y = CH2 CO and Z = OH) Indole-3-ethanethiol (1.5 g.) and methyl acetoacetate are mixed with 50 ml. of benzene and the solution heated for 30 min. (bath temperature 70°-80° C.). p-Toluenesulfonic acid (0.15 g.) is added and the reaction mixture is subjected to reflux and stirring for 12 hours. Water formed in the reaction mixture during this period is collected by a water separator. After cooling the benzene solution is washed with a 10% solution of sodium bicarbonate, water, saturated brine and dried over sodium sulfate. Evaporation of the benzene solution yields the ester, 1-methyl-1, 3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid methyl ester as a semi-solid, γmaxCHCl3 1715 cm-1. This ester is then treated with aqueous alcoholic KOH in the manner described for the esters in Example 1 and 2 to afford the title compound, m.p. 147°-149° C., nmr (CDCl3) δ1.86 (S, 3H), 3.06 and 8.12 (6H), 7.35 (multiplet, 4H), 8.71 (1H), 10.31 (1H), after recrystallization from benzene-hexane.
	With sodium hydrogencarbonate; toluene-4-sulfonic acid In water; benzene	3 1-Methyl-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid (VII; R1 = CH3, R2, R3, R4, R5, R6 and R7 = H, X = S and Z = CH2 COOH) EXAMPLE 3 1-Methyl-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid (VII; R1 = CH3, R2, R3, R4, R5, R6 and R7 = H, X = S and Z = CH2 COOH) Indole-3-ethanethiol (1.5 g.) and methyl acetoacetate are mixed with 50 ml. of benzene and the solution heated for 30 min. (bath temperature 70° - 80° C.). p-Toluenesulfonic acid (0.15 g.) is added and the reaction mixture is subjected to reflux and stirring for 12 hours. Water formed in the reaction mixture during this period is collected by a water separator. After cooling the benzene solution is washed with 10% solution of sodium bicarbonate, water, saturated brine and dried over sodium sulfate. Evaporation of the benzene solution yields the ester, 1-methyl-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid methyl ester as a semi-solid, νmaxCHCl3; 1715 cm-1. This ester is then treated with aqueous alcoholic KOH in the manner described for the esters in Examples 1 and 2 to afford the title compound, m.p. 147° - 149° C., nmr (CDCl3) δ1.86 (S, 3H), 3.06, 8.12 (6H), 7.35 (multiplet, 4H), 8.71 (1H), 10.31 (1H), after recrystallization from benzene-hexane.

	With sodium hydrogencarbonate; toluene-4-sulfonic acid In water; benzene	3 1-METHYL-1,3,4,9-TETRAHYDROTHIOPYRANO[3,4-b]INDOLE-1-ACETIC ACID (I; R1 = CH3, R2, R3, R4, R5, R6 AND R7 = H, X = S, Y = CH2 CO AND Z = OH) EXAMPLE 3 1-METHYL-1,3,4,9-TETRAHYDROTHIOPYRANO[3,4-b]INDOLE-1-ACETIC ACID (I; R1 = CH3, R2, R3, R4, R5, R6 AND R7 = H, X = S, Y = CH2 CO AND Z = OH) Indole-3-ethanethiol (1.5 g.) and methyl acetoacetate are mixed with 50 ml. of benzene and the solution heated for 30 min. (bath temperature 70°-80°C.). p-Toluenesulfonic acid (0.15 g.) is added and the reaction mixture is subjected to reflux and stirring for 12 hours. Water formed in the reaction mixture during this period is collected by a water separator. After cooling the benzene solution is washed with a 10% solution of sodium bicarbonate, water, saturated brine and dried over sodium sulfate. Evaporation of the benzene solution yields the ester, 1-methyl-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid methyl ester as the semi-solid, γmaxCHCl3 1715 cm-1. This ester is then treated with aqueous alcoholic KOH in the manner described for the esters in Example 1 and 2 to afford the title compound, m.p. 147°-149°C., nmr (CDCl3) δ1.86 (S, 3H), 3.06 and 8.12 (6H), 7.35 (multiplet, 4H), 8.71 (1H), 10.31 (1H), after recrystallization from benzene-hexane.
	With sodium hydrogencarbonate; toluene-4-sulfonic acid In water; benzene	3 1-METHYL-1,3,4,9-TETRAHYDROTHIOPYRANO[3,4-b]INDOLE-1-ACETIC ACID (VII: R1 = CH3, R2, R3, R4, R5, R6 AND R7 = H, X = S AND Z = CH2 COOH) EXAMPLE 3 1-METHYL-1,3,4,9-TETRAHYDROTHIOPYRANO[3,4-b]INDOLE-1-ACETIC ACID (VII: R1 = CH3, R2, R3, R4, R5, R6 AND R7 = H, X = S AND Z = CH2 COOH) Indole-3-ethanethiol (1.5 g.) and methyl acetoacetate are mixed with 50 ml. of benzene and the solution heated for 30 min. (bath temperature 70°-80° C.). p-Toluenesulfonic acid (0.15 g.) is added and the reaction mixture is subjected to reflux and stirring for 12 hours. Water formed in the reaction mixture during this period is collected by a water separator. After cooling the benzene solution is washed with 10% solution of sodium bicarbonate, water, saturated brine and dried over sodium sulfate. Evaporation of the benzene solution yields the ester, 1-methyl-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole-1-acetic acid methyl ester as a semi-solid,γmaxCHCl3 1715 cm-1. This ester is then treated with aqueous alcoholic KOH in the manner described for the esters in Examples 1 and 2 to afford the title compound, m.p. 147°-149° C., nmr (CDCl3) δ1.86 (S, 3H), 3.06, 8.12 (6H), 7.35 (multiplet, 4H), 8.71 (1H), 10.31 (1H), after recrystallization from benzene-hexane.

Reference： [1]Current Patent Assignee: PFIZER INC - US3939178, 1976, A
[2]Current Patent Assignee: PFIZER INC - US4012417, 1977, A
[3]Current Patent Assignee: PFIZER INC - US4066780, 1978, A
[4]Current Patent Assignee: PFIZER INC - US3974179, 1976, A
[5]Current Patent Assignee: PFIZER INC - US4003913, 1977, A

18
[ 99-61-6 ]
[ 15774-06-8 ]
[ 1612156-39-4 ]

Yield	Reaction Conditions	Operation in experiment
31%	Stage #1: 3-nitro-benzaldehyde; 2-(1H-indol-3-yl)ethane-1-thiol In toluene at 70℃; for 0.5h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In toluene for 14h; Reflux;	I-2 Preparation of 1-(3-nitrophenyl)-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole (6) Preparation of 1-(3-nitrophenyl)-1,3,4,9-tetrahydrothiopyrano[3,4-b]indole (6). Thiotryptophol (200.3 mg, 1.13 mmol) and 3-nitrobenzaldehyde (204 mg, 1.35 mmol) were dissolved in anhydrous toluene under argon atmosphere and stirred at 70°C for 30 min. Para-toluenesulfonic acid monohydrate (106.5 mg, 0.56 mmol) was then added and the mixture was further refluxed for 14 h. Solvent evaporation under reduced pressure followed by chromatography on silica gel (cHex/AcOEt 10/0 to 7/3) afforded 6 as a white solid (109 mg, 31%). [0051] 1H RMN (400 MHz, CDCl3) δ 2.95-3.08 (m, 2H), 3.11-3.26 (m, 2H), 5.30 (s, 1H), 7.14-7.26 (m, 3H), 7.48 (t, J= 8.2 Hz, 1H), 7.55-7.59 (m, 3H), 8.13-8.15 (m, 2H). [0052] 13C RMN (100 MHz, CDCl3) δ 23.5, 25.6, 41.0, 111.0, 112.9, 118.7, 120.1, 123.0, 123.1, 123.3, 127.6, 129.4, 129.9, 134.4, 135.4, 144.1, 148.7. [0053] HPLC: tR = 9.63 min. [0054] MS: m/z 311 ([M+H]+). [0055] HRMS-ESI-TOF: m/z calculated 309.0698, found 309.0697 ([M-H]-)
31%	Stage #1: 3-nitro-benzaldehyde; 2-(1H-indol-3-yl)ethane-1-thiol In toluene at 70℃; for 0.5h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In toluene for 14h; Reflux;	6 Thiotryptophol (200.3 mg, 1.13 mmol) and 3-nitrobenzaldehyde (204 mg, 1.35 mmol) were dissolved in anhydrous toluene under argon atmosphere and stirred at 70°C for 30 min. Para-toluenesulfonic acid monohydrate (106.5 mg, 0.56 mmol) was then added and the mixture was further refluxed for 14 h. Solvent evaporation under reduced pressure followed by chromatography on silica gel (cHex/AcOEt 10/0 to 7/3) afforded 6 as a white solid (109 mg, 31%).

Reference： [1]Current Patent Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES - EP2738173, 2014, A1 Location in patent: Paragraph 0048; 0049; 0050; 0051; 0052; 0053; 0054; 0055
[2]Current Patent Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES - WO2014/83529, 2014, A1 Location in patent: Page/Page column 14

19
[ 3389-21-7 ]
[ 15774-06-8 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-(2-bromoethyl)-1H-indole With sodium thiosulfate In ethanol; water Reflux; Stage #2: In isopropyl alcohol Reflux; Stage #3: With phosphoric acid In diethyl ether; water Reflux;
	Stage #1: 3-(2-bromoethyl)-1H-indole With thiourea In ethanol Reflux; Inert atmosphere; Stage #2: With water; sodium hydroxide In ethanol Reflux; Inert atmosphere;

Reference： [1]Schunk, Stefan; Linz, Klaus; Hinze, Claudia; Frormann, Sven; Oberbörsch, Stefan; Sundermann, Bernd; Zemolka, Saskia; Englberger, Werner; Germann, Tieno; Christoph, Thomas; Kögel, Babette-Y.; Schröder, Wolfgang; Harlfinger, Stephanie; Saunders, Derek; Kless, Achim; Schick, Hans; Sonnenschein, Helmut [ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 857 - 862]
[2]Kavanagh, Madeline E.; Gray, Janine L.; Gilbert, Sophie H.; Coyne, Anthony G.; McLean, Kirsty J.; Davis, Holly J.; Munro, Andrew W.; Abell, Chris [ChemMedChem, 2016, p. 1924 - 1935]

20
[ 10090-05-8 ]
[ 65619-20-7 ]
[ 15774-06-8 ]
4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-thiopyrano[3,4-b]-indol]-4-amine [ No CAS ]
C₂₄H₂₈N₂S*CH₄O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 306 mg 2: 182 mg	In dichloromethane at 20℃; for 96h; Inert atmosphere;

21
[ 5241-64-5 ]
[ 15774-06-8 ]
S-(2-(1H-indol-3-yl)ethyl) (R)-2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanethioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;

Reference： [1]Kavanagh, Madeline E.; Gray, Janine L.; Gilbert, Sophie H.; Coyne, Anthony G.; McLean, Kirsty J.; Davis, Holly J.; Munro, Andrew W.; Abell, Chris [ChemMedChem, 2016, p. 1924 - 1935]

22
[ 15774-06-8 ]
S-(2-(1H-indol-3-yl)ethyl) (R)-2-amino-3-(1H-indol-3-yl)propanethioate hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
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P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 15774-06-8 ] {[proInfo.proName]}

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[ 15774-06-8 ] Synthesis Path-Downstream 1~22

Precautionary Statements-General

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Response

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Health hazards

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