15777-59-0|3-Bromo-5-phenyl-1H-1,2,4-triazole| Ambeed

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CAS No. :	15777-59-0
Formula :	C₈H₆BrN₃
M.W :	224.06
SMILES Code :	BrC1=NNC(C2=CC=CC=C2)=N1
MDL No. :	MFCD13188619

Yield	Reaction Conditions	Operation in experiment
11 g	With hydrogen bromide; sodium nitrite; at -5 - 20℃; for 0.333333h;Reflux;	6.02.04.37 5-bromo-3-phenyl-lH-(l, 2, 4) triazole 115 mL bromine hydro acid was added to 9.5 g 5-phenyl-2H-(l, 2, 4) triazol-3-ylamine and 12.3 g sodiumnitrite at -5°C. The reaction was warmed to RT and refluxed for 20 min. Then the mixture was cooled and basicfied with sodiumdicarbonate and extracted with ethyl acetate. The organic layer was dried and evaporated to give 11 g of the desired product. Rt: 1.07 min (method B), (M+H)+: 223/225
11 g	With hydrogen bromide; sodium nitrite; at -5 - 20℃; for 0.333333h;Reflux;	6.02.04.37 5-bromo-3-phenyl-1H-(1,2,4)triazole 115 mL bromine hydro acid was added to 9.5 g <strong>[4922-98-9]5-phenyl-2H-(1,2,4)triazol-3-ylamine</strong> and 12.3 g sodiumnitrite at -5° C. The reaction was warmed to RT and refluxed for 20 min. Then the mixture was cooled and basicfied with sodiumdicarbonate and extracted with ethyl acetate. The organic layer was dried and evaporated to give 11 g of the desired product. Rt: 1.07 min (method B), (M+H)+: 223/225 By using the same synthesis strategy as for 5-bromo-3-phenyl-1H-(1,2,4)triazole the following compound was obtained:

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H261	In contact with water releases flammable gas
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Code	Phrase
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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 15777-59-0

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CAS No.: 15777-59-0

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