Name: 158922-07-7|1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid|97%
Brand: Ambeed
SKU: A216420
Price: 18.0 USD
Availability: InStock
Rating: 97 (28 reviews)

1
[ 814-68-6 ]
[ 100-46-9 ]
[ 158922-07-7 ]
3-[Benzyl-(piperidine-3-carbonyl)-amino]-propionic acid; compound with trifluoro-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Yield given. Multistep reaction;

Reference： [1]Hamper, Bruce C.; Kolodziej, Stephen A.; Scates, Angela M.; Smith, Ronald G.; Cortez, Enriqueta [Journal of Organic Chemistry, 1998, vol. 63, # 3, p. 708 - 718]

2
[ 814-68-6 ]
[ 158922-07-7 ]
Piperidine-3-carboxylic acid 2-carboxy-ethyl ester; compound with trifluoro-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Yield given. Multistep reaction;

Reference： [1]Hamper, Bruce C.; Kolodziej, Stephen A.; Scates, Angela M.; Smith, Ronald G.; Cortez, Enriqueta [Journal of Organic Chemistry, 1998, vol. 63, # 3, p. 708 - 718]

3
[ 59-67-6 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-(3-(1H-indol-3-yl)-2-[1-(pyridine-3-carbonyl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

4
[ 16629-19-9 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-(3-(1H-indol-3-yl)-2-[1-(thiophene-2-sulfonyl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

5
[ 94-53-1 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(benzo[1,3]dioxole-5-carbonyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

6
[ 2861-28-1 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(benzo[1,3]dioxol-5-yl-acetyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

7
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(2,3-difluoro-benzyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

8
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(4-chloro-benzo[1,3]dioxol-5-ylmethyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

9
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-{3-(1H-indol-3-yl)-2-[(1-naphthalen-2-ylmethyl-piperidine-3-carbonyl)-amino]-butyrylamino}-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

10
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(3,4-difluoro-benzyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

11
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(3-fluoro-benzyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

12
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-(3-(1H-indol-3-yl)-2-[1-(3-methoxy-benzyl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

13
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
3-{3-[1-(5-amino-1-tert-butoxycarbonyl-pentylcarbamoyl)-2-(1H-indol-3-yl)-propylcarbamoyl]-piperidin-1-ylmethyl}-benzoic acid methyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

14
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[(1-biphenyl-2-ylmethyl-piperidine-3-carbonyl)-amino]-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

15
[ 103-71-9 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-{3-(1H-indol-3-yl)-2-[(1-phenylcarbamoyl-piperidine-3-carbonyl)-amino]-butyrylamino}-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

16
[ 503-74-2 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-(3-(1H-indol-3-yl)-2-[1-(3-methyl-butyryl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

17
[ 10147-37-2 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-(3-(1H-indol-3-yl)-2-[1-(propane-2-sulfonyl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

18
[ 117-34-0 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[(1-diphenylacetyl-piperidine-3-carbonyl)-amino]-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

19
[ 349-88-2 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(4-fluoro-benzenesulfonyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

20
[ 587-48-4 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
2-[2-[1-(3-acetylamino-benzoyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-6-amino-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

21
[ 23095-31-0 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(3,4-dimethoxy-benzenesulfonyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

22
[ 105184-38-1 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-({1-[(3,5-difluoro-phenyl)-acetyl]-piperidine-3-carbonyl}-amino)-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

23
[ 40203-94-9 ]
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
(S)-6-Amino-2-((2S,3S)-3-(1H-indol-3-yl)-2-[1-((S)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

24
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-{3-(1H-indol-3-yl)-2-[(piperidine-3-carbonyl)-amino]-butyrylamino}-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

25
[ 82004-77-1 ]
[ 64-19-7 ]
[ 3173-53-3 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[(1-cyclohexylcarbamoyl-piperidine-3-carbonyl)-amino]-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

26
[ 82004-77-1 ]
[ 64-19-7 ]
[ 15788-16-6 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[1-(3H-benzoimidazole-5-carbonyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

27
[ 82004-77-1 ]
[ 64-19-7 ]
[ 76-93-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
(S)-6-Amino-2-[(2S,3S)-2-[1-(2-hydroxy-2,2-diphenyl-acetyl)-piperidine-3-carbonyl]-amino}-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

28
[ 82004-77-1 ]
[ 64-19-7 ]
[ 65-85-0 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[(1-benzoyl-piperidine-3-carbonyl)-amino]-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

29
[ 82004-77-1 ]
[ 64-19-7 ]
[ 18908-07-1 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-(3-(1H-indol-3-yl)-2-[1-(3-methoxy-phenylcarbamoyl)-piperidine-3-carbonyl]-amino}-butyrylamino)-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

30
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
[ 1795-48-8 ]
6-amino-2-{3-(1H-indol-3-yl)-2-[(1-isopropylcarbamoyl-piperidine-3-carbonyl)-amino]-butyrylamino}-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

31
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[(1-benzyl-piperidine-3-carbonyl)-amino]-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

32
[ 82004-77-1 ]
[ 64-19-7 ]
[ 158922-07-7 ]
N-Fmoc-β-methyl-L-Trp [ No CAS ]
6-amino-2-[2-[(1-benzhydryl-piperidine-3-carbonyl)-amino]-3-(1H-indol-3-yl)-butyrylamino]-hexanoic acid tert-butyl ester; compound with acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Zhou, Changyou; Guo, Liangqin; Morriello, Greg; Pasternak, Alex; Pan, Yanping; Rohrer, Susan P.; Birzin, Elizebeth T.; Huskey, Su-Er Wu; Jacks, Tom; Schleim, Klaus D.; Cheng, Kang; Schaeffer, James M.; Patchett, Arthur A.; Yang, Lihu [Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 415 - 417]

33
[ 35661-60-0 ]
[ 71989-31-6 ]
[ 108-24-7 ]
[ 158922-07-7 ]
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4(bis(dimethylamino)phosphoryloxy)phenyl)propanoic acid [ No CAS ]
Ac-pTyr-Leu-Pro-Nip-NH₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
19.5 mg	Multistep reaction;

Reference： [1]Coleman IV, David R.; Ren, Zhiyong; Mandal, Pijus K.; Cameron, Arlin G.; Dyer, Garrett A.; Muranjan, Seema; Campbell, Martin; Chen, Xiaomin; McMurray, John S. [Journal of Medicinal Chemistry, 2005, vol. 48, # 21, p. 6661 - 6670]

34
[ 108-24-7 ]
[ 71989-35-0 ]
[ 133464-46-7 ]
[ 158922-07-7 ]
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4(bis(dimethylamino)phosphoryloxy)phenyl)propanoic acid [ No CAS ]
Ac-Tyr(PO₃H₂)-Leu-Nip-Gln-Thr-NH₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
13.0 mg	Multistep reaction;

Reference： [1]Coleman IV, David R.; Ren, Zhiyong; Mandal, Pijus K.; Cameron, Arlin G.; Dyer, Garrett A.; Muranjan, Seema; Campbell, Martin; Chen, Xiaomin; McMurray, John S. [Journal of Medicinal Chemistry, 2005, vol. 48, # 21, p. 6661 - 6670]

35
[ 158922-07-7 ]
[ 942272-46-0 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 3h;

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

36
[ 28920-43-6 ]
[ 498-95-3 ]
[ 158922-07-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 3371 - 3375

37
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 82-58-6 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid [ No CAS ]
C₄₁H₅₁FN₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

38
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 82-58-6 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid [ No CAS ]
C₄₁H₅₁FN₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

39
[ 95753-55-2 ]
[ 158922-07-7 ]
[ 82-58-6 ]
Fmoc-homocyclohexylalanine [ No CAS ]
C₄₁H₅₁N₇O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

40
[ 95753-55-2 ]
[ 158922-07-7 ]
[ 82-58-6 ]
Fmoc-homocyclohexylalanine [ No CAS ]
C₄₁H₅₁N₇O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

41
[ 68858-20-8 ]
[ 158922-07-7 ]
[ 82-58-6 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid [ No CAS ]
C₃₇H₅₂N₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

42
[ 68858-20-8 ]
[ 158922-07-7 ]
[ 82-58-6 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid [ No CAS ]
C₃₇H₅₂N₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

43
[ 108-24-7 ]
[ 95753-55-2 ]
[ 158922-07-7 ]
Fmoc-homocyclohexylalanine [ No CAS ]
C₂₇H₃₉N₅O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

44
[ 68858-20-8 ]
[ 108-24-7 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid [ No CAS ]
C₂₃H₄₀N₄O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

45
[ 95753-55-2 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 82-58-6 ]
C₄₀H₄₂FN₇O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

46
[ 95753-55-2 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 82-58-6 ]
C₄₀H₄₂FN₇O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

47
[ 68858-20-8 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 82-58-6 ]
C₃₆H₄₃FN₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

48
[ 68858-20-8 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 82-58-6 ]
C₃₆H₄₃FN₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction.;

Reference： [1]Vendrell, Marc; Angulo, Ester; Casadó, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam [Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3062 - 3069]

49
[ 108-24-7 ]
[ 95753-55-2 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
C₂₆H₃₀FN₅O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

50
[ 68858-20-8 ]
[ 95753-55-2 ]
[ 158922-07-7 ]
[ 82-58-6 ]
C₃₆H₄₃N₇O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

51
[ 68858-20-8 ]
[ 95753-55-2 ]
[ 158922-07-7 ]
[ 82-58-6 ]
C₃₆H₄₃N₇O₆ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3062 - 3069

52
[ 158922-07-7 ]
[ 883106-74-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: SOCl₂; DMF / CH₂Cl₂ / 3 h / 20 °C 2: aq. NaHCO₃ / CHCl₃ / 1 h / 20 °C 3: 4-aminomethylpiperidine / CHCl₃ / 12 h / 20 °C

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

53
[ 158922-07-7 ]
1-methyl-piperidine-3-carboxylic acid (6-methyl-pyridin-2-yl)-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: SOCl₂; DMF / CH₂Cl₂ / 3 h / 20 °C 2: aq. NaHCO₃ / CHCl₃ / 1 h / 20 °C 3: 4-aminomethylpiperidine / CHCl₃ / 12 h / 20 °C 4: aq. HCOOH / 3 h / Heating

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

54
[ 158922-07-7 ]
1-benzyl-piperidine-3-carboxylic acid (6-methyl-pyridin-2-yl)-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: SOCl₂; DMF / CH₂Cl₂ / 3 h / 20 °C 2: aq. NaHCO₃ / CHCl₃ / 1 h / 20 °C 3: 4-aminomethylpiperidine / CHCl₃ / 12 h / 20 °C 4: K₂CO₃ / dimethylformamide / 2 h / 80 °C

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

55
[ 158922-07-7 ]
1-(3-chloro-benzyl)-piperidine-3-carboxylic acid (6-methyl-pyridin-2-yl)-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: SOCl₂; DMF / CH₂Cl₂ / 3 h / 20 °C 2: aq. NaHCO₃ / CHCl₃ / 1 h / 20 °C 3: 4-aminomethylpiperidine / CHCl₃ / 12 h / 20 °C 4: K₂CO₃ / dimethylformamide / 2 h / 80 °C

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

56
[ 158922-07-7 ]
1-(toluene-4-sulfonyl)-piperidine-3-carboxylic acid (6-methyl-pyridin-2-yl)-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: SOCl₂; DMF / CH₂Cl₂ / 3 h / 20 °C 2: aq. NaHCO₃ / CHCl₃ / 1 h / 20 °C 3: 4-aminomethylpiperidine / CHCl₃ / 12 h / 20 °C 4: TEA / CH₂Cl₂ / 1 h / 0 - 5 °C

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

57
[ 158922-07-7 ]
3-(6-methyl-pyridin-2-ylcarbamoyl)-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂; DMF / CH₂Cl₂ / 3 h / 20 °C 2: aq. NaHCO₃ / CHCl₃ / 1 h / 20 °C

Reference： [1]Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3371 - 3375]

58
[ 158922-07-7 ]
[ 75-65-0 ]
[ 635722-83-7 ]

Yield	Reaction Conditions	Operation in experiment
	With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine at 60℃; for 18h;	120.a 1.84 g of diisopropylethylamine and 4.71 g of diphenylphosphorylazide were added to 10 ml of a t-butanol solution of 5.01 g of 9H-fluoren-9-ylmethyl 3-carboxypiperidine-1-carboxylate, and the mixture was heated at 60°C under a nitrogen atmosphere for 18 hours. The reaction solution was cooled, and 150 ml of ethyl acetate was added thereto. The organic layer was washed successively with 100 ml of 5% aqueous sulfuric acid, 100 ml of 5% aqueous sodium bicarbonate solution, 100 ml of water, and 100 ml of a saturated sodium chloride solution, and then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 1.88 g of the title compound was obtained from the fraction eluted with hexane-ethyl acetate (4:1). 1H-NMR(CDCl3) δ 1.45 (s, 9H) 1.45-1.72 (m, 3H) 1.82-1.87 (br.s, 1H) 3.09-3.30 (br.s, 2H) 3.58 (br.s, 2H) 3.82-3.98 (br.s, 1H) 4.24 (t, J=7.2 Hz, 1H) 4.27-4.48 (br.s, 2H) 4.52-4.59 (br.s, 1H) 7.32 (dd, J=10.3, 10.0 Hz, 2H) 7.39 (t, J=10.0 Hz, 2H) 7.59 (d, J=10.0 Hz, 2H) 7.75 (d, J=10.3 Hz, 2H)
	With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine at 60℃; for 18h;	120.a (a) 9H-fluoren-9-ylmethyl 3-t-butoxycarbonylaminopiperidine-1-carboxylate 1.84 g of diisopropylethylamine and 4.71 g of diphenylphosphorylazide were added to 10 ml of a t-butanol solution of 5.01 g of 9H-fluoren-9-ylmethyl 3-carboxypiperidine-1-carboxylate, and the mixture was heated at 60° C. under a nitrogen atmosphere for 18 hours. The reaction solution was cooled, and 150 ml of ethyl acetate was added thereto. The organic layer was washed successively with 100 ml of 5% aqueous sulfuric acid, 100 ml of 5% aqueous sodium bicarbonate solution, 100 ml of water, and 100 ml of a saturated sodium chloride solution, and then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 1.88 g of the title compound was obtained from the fraction eluted with hexane-ethyl acetate (4:1).

Reference： [1]Current Patent Assignee: EISAI CO LTD - EP1557165, 2005, A1 Location in patent: Page/Page column 83
[2]Current Patent Assignee: EISAI CO LTD - US2007/219178, 2007, A1 Location in patent: Page/Page column 47

59
C₃H₉N₂Pol [ No CAS ]
[ 158922-07-7 ]
C₂₄H₂₈N₃O₃Pol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) for 4.25h;	1 To 10 g (14.9 mmol) of the above resin 4 was added the solution produced by mixing 22.6 g (60 mmol, 4 eq) of HBTU, 2.0 g (14.9 mmol, 1 eq) of HOBT, 21.8 g (60 mmol, 4 eq) of (R,S)-Fmoc-nipecotic acid and 20 mL (120 mmol, 8 eq) of iPr2NEt in 125 mL of dry DMF for 15 minutes. The resin was shaken for 4 h when it was washed and dried to give resin 5. The resin was then treated with 100 mL of 20% piperidine in DMF for 90 min when it was washed and dried to produce the product resin 6.

Reference： [1]Current Patent Assignee: MEDIQUEST THERAPEUTICS, INC. - US2005/209264, 2005, A1 Location in patent: Page/Page column 11

60
C₉H₁₂NPol [ No CAS ]
[ 158922-07-7 ]
C₃₀H₃₁N₂O₃Pol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 20℃;	II.20.2 The MiniKans from the previous step were suspended in a 50/50 mixture of dichoromethane and DMF, and then N-Fmoc nipecotic acid (Chem-Impex International, Inc., Wood Dale, Ill.; 7 eq.), bromotris(pyrrolydino)phophonium hexafluorophosphate (PyBroP; Calbiochem-NovaBiochem Corp., San Diego, Calif.; 7 eq.) or O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate (HBTU; Alfa Aesar, Ward Hill, Mass.; 7 eq.), and diisopropylethylamine (7 eq.) were added. The reaction was carried out at room temperature overnight. After the reaction solution was drained from the reaction vessel, MiniKans were washed and dried as described above.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - US2006/199816, 2006, A1 Location in patent: Page/Page column 30; 32

61
[ 4129-17-3 ]
[ 144-55-8 ]
[ 158922-07-7 ]
[ 635722-83-7 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; N-ethyl-N,N-diisopropylamine In water; ethyl acetate; <i>tert</i>-butyl alcohol	120.a (a) (a) 9H-fluoren-9-ylmethyl 3-t-butoxycarbonylaminopiperidine-1-carboxylate 1.84 g of diisopropylethylamine and 4.71 g of diphenylphosphorylazide were added to 10 ml of a t-butanol solution of 5.01 g of 9H-fluoren-9-ylmethyl 3-carboxypiperidine-1-carboxylate, and the mixture was heated at 60° C. under a nitrogen atmosphere for 18 hours. The reaction solution was cooled, and 150 ml of ethyl acetate was added thereto. The organic layer was washed successively with 100 ml of 5% aqueous sulfuric acid, 100 ml of 5% aqueous sodium bicarbonate solution, 100 ml of water, and 100 ml of a saturated sodium chloride solution, and then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 1.88 g of the title compound was obtained from the fraction eluted with hexane-ethyl acetate (4:1). 1H-NMR(CDCl3) δ 1.45 (s, 9H) 1.45-1.72 (m, 3H) 1.82-1.87 (br.s, 1H) 3.09-3.30 (br.s, 2H) 3.58 (br.s, 2H) 3.82-3.98 (br.s, 1H) 4.24 (t, J=7.2 Hz, 1H) 4.27-4.48 (br.s, 2H) 4.52-4.59 (br.s, 1H) 7.32 (dd, J=10.3, 10.0 Hz, 2H) 7.39 (t, J=10.0 Hz, 2H) 7.59 (d, J=10.0 Hz, 2H) 7.75 (d, J=10.3 Hz, 2H)

Reference： [1]Current Patent Assignee: EISAI CO LTD - US2004/116328, 2004, A1

62
N-methyl-4-piperidinepropanoic acid [ No CAS ]
[ 35737-10-1 ]
[ 158922-07-7 ]
N-3-(4-N-methylpiperidinepropionyl)nipecotyl-3-aminopropionic acid.TFA [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: N-Fmoc-β-alanine With piperidine In DMF (N,N-dimethyl-formamide) for 2h; Stage #2: Fmoc-nipecotic acid With N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide In DMF (N,N-dimethyl-formamide) for 16h; Stage #3: N-methyl-4-piperidinepropanoic acid With piperidine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide more than 3 stages;

Reference： [1]Current Patent Assignee: JOHNSON & JOHNSON INC - EP1184374, 2002, A1 Location in patent: Page 24

63
[ 6214-20-6 ]
[ 35661-40-6 ]
[ 77128-73-5 ]
[ 158922-07-7 ]
[ 1215027-82-9 ]

Reference： [1]Journal of Medicinal Chemistry,2010,vol. 53,p. 2354 - 2363

64
[ 21169-71-1 ]
[ 71989-23-6 ]
[ 7144-05-0 ]
[ 135673-97-1 ]
[ 158922-07-7 ]
[ 1252806-75-9 ]

Reference： [1]Journal of Medicinal Chemistry,2010,vol. 53,p. 7428 - 7440

65
C₂₄H₄₂N₇O₅PolS [ No CAS ]
[ 95753-55-2 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
C₄₈H₆₇FN₁₁O₁₀PolS [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 1080 - 1090

66
C₂₂H₃₉N₆O₄PolS [ No CAS ]
[ 95753-55-2 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
C₄₆H₆₄FN₁₀O₉PolS [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 1080 - 1090

67
[ 33305-77-0 ]
[ 158922-07-7 ]
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid [ No CAS ]
[ 1268722-95-7 ]