Name: Fmoc-Val-OH | Fmoc-L-Val-OH; FMOC-L-valine
Brand: Ambeed
SKU: A205270

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Fmoc-Val-OH is a protected valine derivative with the amino group protected by 9-fluorenylmethoxycarbonyl (Fmoc), suitable for peptide synthesis.

Synonyms: Fmoc-L-Val-OH; FMOC-L-valine; Fmoc-valine

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Quality Control of Fmoc-Val-OH Purity: 97% SDS Specification

COA

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NMR

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CNMR

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HPLC

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LC-MS

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Product Details of Fmoc-Val-OH

CAS No. :	68858-20-8
Formula :	C₂₀H₂₁NO₄
M.W :	339.39
SMILES Code :	CC(C)[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Synonyms :	Fmoc-L-Val-OH; FMOC-L-valine; Fmoc-valine
MDL No. :	MFCD00037124
InChI Key :	UGNIYGNGCNXHTR-SFHVURJKSA-N
Pubchem ID :	688217

Safety of Fmoc-Val-OH

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of Fmoc-Val-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 68858-20-8 ]

[ 68858-20-8 ] Synthesis Path-Downstream 1~35

1
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 35661-40-6 ]
[ 108-24-7 ]
[ 198561-07-8 ]
Ac-Val-Asp-Phe-Gly-OH [ No CAS ]

References: [1]Organic Letters,2007,vol. 9,p. 2469 - 2472.

2
C₃₄H₂₈N₂O₇ [ No CAS ]
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 35661-60-0 ]
[ 35661-39-3 ]
[ 122889-11-6 ]
[ 71989-31-6 ]
[ 71989-18-9 ]
[ 103213-32-7 ]
[ 86060-81-3 ]
[ 116611-64-4 ]
[ 223416-45-3 ]

Yield	Reaction Conditions	Operation in experiment
		Chelmical synthesis: Peptides were synthesized on a Rink amide resin, 0.45 mmol/g [Fmoc-Cys(Trityl)-Wang; Novabiochem, San Diego, Calif.] usinig N-(9-fluorenyl)methoxycarboxyl chemistry and standard side chain protection except on cysteine residues. Cysteine residues were protected in pairs with either S-trityl on the first and third cysteines or S-acetamidomethyl on the second and fourth cysteines. Amino acid derivatives were from Advanced Chemtech (Louisville, Ky.). The peptides were removed from the resin and precipitated, and a two-step oxidation protocol was used to selectively fold the peptides as described previously (Luo et al., 1999). Briefly, the first disulfide bridge was closed by dripping the peptide into an equal volume of 20 mM potassium feliicyanide and 0.1 M Tris, pH 7.5. The solution was allowed to react for 30 min, and the monocyclic peptide was purified by reverse-phase HPLC. Simultaneous removal of the S-acetamidomethyl groups and closure of the second disulfide bridge was carried out by iodine oxidation. The monocyclic peptide and HPLC eluent was dripped into an equal volume of iodine (10 mM) in H20/trifluoroacetic acid/acetonitrile (78:2:20 by volume) and allowed to react for 10 min. The reaction was terminated by the addition of ascorbic acid diluted 20-fold with 0.1percent trifluoroacetic acid and the bicyclic product purified by HPLC. Mass Spectrometry: Measurements were performed at the Salk Institute for Biological Studies (San Diego, Calif.) under the direction of Jean Rivier. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry and liquid secondary ionization mass spectrometry were used.

References: [1]Patent: US2006/211623,2006,A1 .Location in patent: Page/Page column 9.

3
[ 6456-74-2 ]
[ 68858-20-8 ]
[ 198561-07-8 ]
[ 1134204-67-3 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3031 - 3035.

4
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 71989-33-8 ]
[ 71989-14-5 ]
[ 71989-18-9 ]
[ 108-24-7 ]
[ 71989-23-6 ]
[ 71989-16-7 ]
[ 91000-69-0 ]
[ 198561-07-8 ]
C₅₇H₉₃N₁₇O₂₂ [ No CAS ]

References: [1]Organic Letters,2011,vol. 13,p. 5604 - 5607.

5
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 35661-60-0 ]
[ 152338-45-9 ]
[ 185031-78-1 ]
[ 122889-11-6 ]
[ 71989-31-6 ]
[ 71989-23-6 ]
[ 117872-75-0 ]
[ 136050-67-4 ]
GTCNTPGCTCSWPVCQIPGLGPLCGETCVG cyclic (3->15),(8->24),(10->28)-tris(disulfide) [ No CAS ]

References: [1]Angewandte Chemie - International Edition,2012,vol. 51,p. 5620 - 5624.

6
[ 159610-89-6 ]
[ 68858-20-8 ]
[ 71989-38-3 ]
[ 71989-26-9 ]
[ 77284-32-3 ]
[ 94744-50-0 ]
N,N'-bis(tert-butyloxycarbonyl)-L-lysine dicyclohexylamine salt [ No CAS ]
[ 198561-07-8 ]
[ 1443329-49-4 ]

References: [1]Journal of Peptide Science,2013,vol. 19,p. 423 - 432.

7
Fmoc-Ala-O-Wang resin [ No CAS ]
[ 124-07-2 ]
[ 29022-11-5 ]
[ 68858-20-8 ]
[ 35661-39-3 ]
[ 35661-40-6 ]
[ 118904-37-3 ]
[ 71989-18-9 ]
[ 73724-45-5 ]
[ 125238-99-5 ]
[ 84624-17-9 ]
N-α-(9-fluorenylmethyloxycarbonyl)-N-γ-tert-butyloxycarbonyl-D-2,4-diaminobutyric acid [ No CAS ]
Protected D-Trp derivative [ No CAS ]
[ 1628113-77-8 ]