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Chemical Structure| 1595319-95-1 Chemical Structure| 1595319-95-1

Structure of 1595319-95-1

Chemical Structure| 1595319-95-1

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Product Details of [ 1595319-95-1 ]

CAS No. :1595319-95-1
Formula : C33H32NOPS
M.W : 521.65
SMILES Code : CC([S@](N[C@H](C1=CC=CC=C1P(C2=CC=CC=C2)C3=CC=CC=C3)C4=C5C=CC=CC5=CC=C4)=O)(C)C
English Name :(R)-N-((S)-(2-(diphenylphosphaneyl)phenyl)(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide
MDL No. :MFCD32697147
InChI Key :ZEKRYLFTCRWHOG-XRRNFBIGSA-N
Pubchem ID :102143819

Safety of [ 1595319-95-1 ]

Application In Synthesis of [ 1595319-95-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1595319-95-1 ]

[ 1595319-95-1 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 50777-76-9 ]
  • [ 1595319-95-1 ]
  • [ 1616688-65-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: titanium(IV)isopropoxide / tetrahydrofuran / 50 °C / Inert atmosphere 2: toluene; hexane / -78 - 0 °C / Inert atmosphere
Multi-step reaction with 2 steps 1: titanium(IV)isopropoxide / tetrahydrofuran / 50 °C / Inert atmosphere 2: dichloromethane; diethyl ether / 4 h / -48 °C / Inert atmosphere
  • 2
  • [ 2559743-67-6 ]
  • [ 703-55-9 ]
  • [ 1595319-95-1 ]
  • [ 1616688-65-3 ]
YieldReaction ConditionsOperation in experiment
> 87.5 % de In diethyl ether; dichloromethane at -48℃; for 4h; Inert atmosphere; Overall yield = 83 %; Overall yield = 2.2 g; diastereoselective reaction;
  • 3
  • [ 2559743-67-6 ]
  • [ 14474-59-0 ]
  • [ 1595319-95-1 ]
  • [ 1616688-65-3 ]
YieldReaction ConditionsOperation in experiment
> 87.5 % de In hexane; toluene at -78 - 0℃; Inert atmosphere; Overall yield = 79 %; Overall yield = 2.1 g; diastereoselective reaction;
YieldReaction ConditionsOperation in experiment
68% In tetrahydrofuran at -50℃; Inert atmosphere; 8 synthesis of (R,S)-tert-butylsulfinyl-1-(2-diphenylphosphino)phenethylamine General procedure: The second step: the first step of the preparation of imine (1.91g, 5mmol) was added to 50mL eggplant-shaped reaction flask,Nitrogen protection,Add 15 mL of THF.Methyllithium (10 mmol) was added at -50 ° C and stirred overnight at 75% yield.Other operations Reference Example 1 The metal reagent used was methylmagnesium bromide in a total yield of 60%.
  • 5
  • [ 29892-37-3 ]
  • [ 1595319-95-1 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 20℃; for 2h;
  • 6
  • [ 1595319-95-1 ]
  • [ 2614006-73-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: hydrogenchloride / lithium hydroxide monohydrate; methanol / 20 °C / Inert atmosphere 2.1: glacial acetic acid / methanol / 3 h / 40 °C / Inert atmosphere 2.2: 18 h / 40 °C / Inert atmosphere
  • 7
  • [ 1595319-95-1 ]
  • [ 2614006-92-5 ]
YieldReaction ConditionsOperation in experiment
90% With hydrogenchloride In methanol; lithium hydroxide monohydrate at 20℃; Inert atmosphere;
 

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[ 1595319-95-1 ]

Chemical Structure| 2419935-12-7

A1351655 [2419935-12-7]

(S)-N-((R)-(2-(Diphenylphosphaneyl)phenyl)(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide

Reason: Optical isomers