[ CAS No. 50777-76-9 ] {[proInfo.proName]}

Name: 50777-76-9|2-(Diphenylphosphino)benzaldehyde|97%
Brand: Ambeed
SKU: A195130
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2D 3D

Structure of 50777-76-9 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 50777-76-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 50777-76-9 ]

SDS Specification

Alternatived Products of [ 50777-76-9 ]

Product Details of [ 50777-76-9 ]

CAS No. :	50777-76-9	MDL No. :	MFCD00013367
Formula :	C₁₉H₁₅OP	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	DRCPJRZHAJMWOU-UHFFFAOYSA-N
M.W :	290.30	Pubchem ID :	2754316
Synonyms :

Calculated chemistry of [ 50777-76-9 ]

Physicochemical Properties

Num. heavy atoms :	21
Num. arom. heavy atoms :	18
Fraction Csp3 :	0.0
Num. rotatable bonds :	4
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	90.54
TPSA :	30.66 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.18 cm/s

Lipophilicity

Log Po/w (iLOGP) :	3.05
Log Po/w (XLOGP3) :	4.07
Log Po/w (WLOGP) :	3.26
Log Po/w (MLOGP) :	4.25
Log Po/w (SILICOS-IT) :	5.66
Consensus Log Po/w :	4.06

Druglikeness

Lipinski :	1.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-4.57
Solubility :	0.00774 mg/ml ; 0.0000267 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.42
Solubility :	0.0111 mg/ml ; 0.0000382 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-7.48
Solubility :	0.00000955 mg/ml ; 0.0000000329 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	3.64

Safety of [ 50777-76-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 50777-76-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 50777-76-9 ]
Downstream synthetic route of [ 50777-76-9 ]

[ 50777-76-9 ] Synthesis Path-Upstream 1~19

1
[ 6630-33-7 ]
[ 829-85-6 ]
[ 50777-76-9 ]

Reference： [1] Advanced Synthesis and Catalysis, 2001, vol. 343, # 6-7, p. 711 - 720
[2] Chemistry - A European Journal, 2015, vol. 21, # 36, p. 12735 - 12740
[3] Chemistry of Materials, 2016, vol. 28, # 19, p. 7145 - 7157

2
[ 143024-49-1 ]
[ 50777-76-9 ]

Reference： [1] Organic Letters, 2014, vol. 16, # 2, p. 390 - 393

3
[ 68-12-2 ]
[ 62336-24-7 ]
[ 50777-76-9 ]

Reference： [1] Organic Letters, 2007, vol. 9, # 22, p. 4571 - 4574
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 3, p. 544 - 550

4
[ 50777-73-6 ]
[ 50777-76-9 ]

Reference： [1] Dalton Transactions, 2011, vol. 40, # 14, p. 3695 - 3702
[2] Chemistry - A European Journal, 2013, vol. 19, # 19, p. 6034 - 6043
[3] Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2004, vol. 43, # 11, p. 2287 - 2293
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1999, vol. 54, # 12, p. 1532 - 1542
[5] Organometallics, 2010, vol. 29, # 17, p. 3955 - 3965
[6] RSC Advances, 2015, vol. 5, # 15, p. 11405 - 11422

5
[ 97106-61-1 ]
[ 68-12-2 ]
[ 50777-76-9 ]

Reference： [1] Angewandte Chemie - International Edition, 2016, vol. 55, # 2, p. 802 - 806[2] Angew. Chem., 2016, vol. 128, # 2, p. 813 - 817,5

6
[ 50777-77-0 ]
[ 50777-76-9 ]

Reference： [1] Synthetic Communications, 1992, vol. 22, # 10, p. 1453 - 1459

7
[ 34824-58-3 ]
[ 50777-76-9 ]

Reference： [1] Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2004, vol. 43, # 11, p. 2287 - 2293
[2] Dalton Transactions, 2011, vol. 40, # 14, p. 3695 - 3702
[3] Chemistry - A European Journal, 2013, vol. 19, # 19, p. 6034 - 6043
[4] RSC Advances, 2015, vol. 5, # 15, p. 11405 - 11422

8
[ 6630-33-7 ]
[ 50777-76-9 ]

Reference： [1] Dalton Transactions, 2011, vol. 40, # 14, p. 3695 - 3702
[2] Chemistry - A European Journal, 2013, vol. 19, # 19, p. 6034 - 6043
[3] RSC Advances, 2015, vol. 5, # 15, p. 11405 - 11422

9
[ 1696-17-9 ]
[ 1079-66-9 ]
[ 50777-76-9 ]

Reference： [1] Organic Letters, 2014, vol. 16, # 2, p. 390 - 393

10
[ 1079-66-9 ]
[ 50777-76-9 ]

Reference： [1] Organic and Biomolecular Chemistry, 2006, vol. 4, # 3, p. 544 - 550
[2] Synthetic Communications, 1992, vol. 22, # 10, p. 1453 - 1459

11
[ 1213-51-0 ]
[ 50777-76-9 ]

Reference： [1] Angewandte Chemie - International Edition, 2016, vol. 55, # 2, p. 802 - 806[2] Angew. Chem., 2016, vol. 128, # 2, p. 813 - 817,5
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 2, p. 802 - 806[4] Angew. Chem., 2016, vol. 128, # 2, p. 813 - 817,5
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 2, p. 802 - 806[6] Angew. Chem., 2016, vol. 128, # 2, p. 813 - 817,5

12
[ 829-85-6 ]
[ 50777-76-9 ]

13
[ 2042-37-7 ]
[ 50777-76-9 ]

Reference： [1] Synthetic Communications, 1992, vol. 22, # 10, p. 1453 - 1459

14
[ 34825-99-5 ]
[ 50777-76-9 ]

Reference： [1] Synthetic Communications, 1992, vol. 22, # 10, p. 1453 - 1459

15
[ 164718-49-4 ]
[ 50777-76-9 ]

Reference： [1] Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2004, vol. 43, # 11, p. 2287 - 2293

16
[ 133393-02-9 ]
[ 50777-76-9 ]

Reference： [1] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1999, vol. 54, # 12, p. 1532 - 1542

17
[ 446-52-6 ]
[ 50777-76-9 ]

Reference： [1] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1999, vol. 54, # 12, p. 1532 - 1542

18
[ 848032-09-7 ]
[ 50777-76-9 ]

Reference： [1] Journal of Organic Chemistry, 2018, vol. 83, # 4, p. 1687 - 1700

19
[ 583-55-1 ]
[ 50777-76-9 ]

Reference： [1] Organic and Biomolecular Chemistry, 2006, vol. 4, # 3, p. 544 - 550

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Yield	Reaction Conditions	Operation in experiment
98%	With zirconium dioxide hydrate; isopropyl alcohol at 60℃; for 0.25h;
87%	With C₄₆H₄₉CoN₃P₄⁽²⁺⁾*2BF₄^(1-); hydrogen; potassium hydroxide In ethanol; acetonitrile at 60℃; for 24h; Autoclave; Glovebox; chemoselective reaction;
	With sodium tetrahydroborate

Yield	Reaction Conditions	Operation in experiment
86%	With hydroxyamino hydrochloride; Sodium hydrogenocarbonate In ethanol; water monomer for 2h; Ambient temperature;
70%	With hydroxyamino hydrochloride; Sodium hydrogenocarbonate In ethanol; water monomer for 3h; Schlenk technique; Inert atmosphere; Reflux;
2.6 g	With hydroxyamino hydrochloride; Sodium hydrogenocarbonate In methanol; water monomer for 2h; Heating;

Yield	Reaction Conditions	Operation in experiment
70%	Stage #1: (2-bromophenyl)diphenylphosphane With n-butyllithium In diethyl ether; hexane at -78℃; for 0.333333h; Stage #2: N,N-dimethyl-formamide In diethyl ether; hexane at -78 - 20℃; Further stages.;
	Stage #1: (2-bromophenyl)diphenylphosphane Stage #2: N,N-dimethyl-formamide Further stages.;

Yield	Reaction Conditions	Operation in experiment
82%	In toluene at 20℃; for 1h;	[CuI(2-(diphenylphosphino)benzaldehyde)2] (1) A solution of CuI (0.2 g, 1.05 mmol) in toluene (50 ml) was mixed with 2-(diphenylphosphino) benzaldehyde (0.15 g, 0.52 mmol) also dissolved in toluene (20 ml). The solution is stirred for 1 hour at room temperature. After this time, a yellow precipitate is produced which is collected and dissolved in dichloromethane. After three days, single crystals suitable for X-ray diffraction were obtained by slow evaporation of the dichloromethane. Yield (82%)
17%	In acetonitrile Cu-compd. was stirred in MeCN at 50 °C until a clear soln. was formed, 2 equiv. of P-compd. was added in MeCN, stirirng at 50 °C for 2 h; soln. was filtered and left at ambient temp. to evaporate for several days, solid was filtered off, dried in vac., elem. anal.;
	In acetonitrile Cu-compd. was stirred in MeCN at 50 °C until a clear soln. was formed, 1 equiv. of P-compd. was added in MeCN, stirirng at 50 °C for 2 h; soln. was filtered and left at ambient temp. to evaporate for several days, solid was filtered off, dried in vac., elem. anal.;

[ CAS No. 50777-76-9 ] {[proInfo.proName]}

Quality Control of [ 50777-76-9 ]

Related Doc. of [ 50777-76-9 ]

Product Details of [ 50777-76-9 ]

Calculated chemistry of [ 50777-76-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 50777-76-9 ]

Application In Synthesis of [ 50777-76-9 ]

[ 50777-76-9 ] Synthesis Path-Upstream 1~19

[ 50777-76-9 ] Synthesis Path-Downstream 1~78

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

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Inquiry

	With sodium tetrahydroborate
	With sodium tetrahydroborate
	Multi-step reaction with 2 steps 1.1: dihydrogen peroxide / dichloromethane; water / 3 h / 20 °C / Glovebox; Inert atmosphere 2.1: trityl tetrakis(pentafluorophenyl)borate / ⁽²⁾H₈-toluene / 20 °C / Glovebox; Inert atmosphere 2.2: 80 °C / Glovebox; Inert atmosphere; Sealed tube

Yield	Reaction Conditions	Operation in experiment
94%	In toluene at 150 - 160℃; for 6h; Inert atmosphere;	8 General procedure for the synthesis of iminophosphine ligands (4-12).Procedure A General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150-160 °C oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 °C at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.
92%	In dichloromethane at 20℃; for 16h; Inert atmosphere;	4.2. General procedure for preparation of ligands (1a-f) General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 °C overnight to give an off-white powder, which was filtered and dried in vacuo.
90%	With magnesium sulfate In dichloromethane at 20℃; for 18h;

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: titanium(IV)isopropoxide / tetrahydrofuran / 50 °C / Inert atmosphere 2: dichloromethane; diethyl ether / -48 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: titanium(IV)isopropoxide / tetrahydrofuran / 50 °C / Inert atmosphere 2: toluene; hexane / -78 - 0 °C / Inert atmosphere

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere 2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 20 °C / Schlenk technique; Inert atmosphere 2.2: 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere 2: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane / 25 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere 2: tetrahydrofuran / 20 °C / Inert atmosphere

Yield	Reaction Conditions	Operation in experiment
87%	In toluene; for 5h;	The synthesis of the iminophosphine ligand carryingalkoxylsilane moiety (A) was performed through the reactivedistillation of 2-(diphenylphosphino)benzaldehyde (0.500 g)with 3-(aminopropyl)trimethoxysilane (0.255 g) in dry toluene(25 mL). After 5 hours, we obtained a yellow oily liquidby careful removal of toluene under vacuum (87 % yield).1H NMR (400 MHz, CD2Cl2): delta = 8.8 (s, 1H), 8.02 (s,1H), 7.45-7.27 (m, 12 H), 6.91 (s, 1 H), 3.53 (s, 9 H), 3.46(m, 2 H), 1.68 - 1.60 (m, 2 H), 0.58 - 0.52 (m, 2 H); 13CNMR (100 MHz, CD2Cl2): delta= 158.57, 134.14, 128.79, 65.13,50.82, 24.62, 8.73 ppm.; 31P NMR : (300 MHz, CD2Cl2,ppm) delta= -13.07ppm.
85%	In toluene; for 5h;Inert atmosphere;	The synthesis of the iminophosphine ligand carryingalkoxylsilane moiety A was performed through the reactive distillation of 2-(diphenylphosphino)benzaldehyde(0.500 g) with 3-(aminopropyl)trimethoxysilane (0.250 g)in dry toluene (25 mL). After 5 h, we obtained a yellowoily liquid by careful removal of toluene under vacuum(85 % yield).1H NMR (400 MHz, CD2Cl2): d = 8.8 (s, 1H), 8.02 (s,1H), 7.45-7.27 (m, 12 H), 6.91 (s, 1 H), 3.53 (s, 9 H), 3.46(m, 2 H), 1.68-1.60 (m, 2 H), 0.58-0.52 (m, 2 H); 13CNMR (100 MHz, CD2Cl2): d = 158.57, 134.14, 128.79,65.13, 50.82, 24.62, 8.73 ppm; 31P NMR: (300 MHz,CD2Cl2, ppm) d = -13.07 ppm.

Yield	Reaction Conditions	Operation in experiment
82%	With formic acid In ethanol for 2.5h; Reflux;
80%	In methanol for 2.5h; Inert atmosphere; Schlenk technique; Reflux;

Yield	Reaction Conditions	Operation in experiment
43%	With sodium dithionite In ethanol; water at 75℃; for 5h;
43%	With sodium dithionite In ethanol; water at 75℃; for 5h;
43%	With sodium dithionite In ethanol; water for 5h; Reflux;	Synthesis of HL1 General procedure: The 2-nitroaniline (0.71g, 5mmol), 2-(diphenylphosphino)benzaldehyde (1.74g, 6mmol) and sodium hydrosulfite (3.48g, 20mmol) in a mixture of the ethanol and water (v/v=5:1) were refluxed for 5h. The reaction mixture was filtered to remove the precipitated base. Then, the filtrate was concentrated under reduced pressure to remove the mixture of ethanol and water, and then extracted with ethyl acetate. The crude product was purified by silica gel column chromatography using dichloromethane/ethyl acetate (10:1) as the eluent to afford HL1 as a white solid (0.93g, 47% yield).

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling