[ CAS No. 16024-82-1 ] {[proInfo.proName]}

Name: 16024-82-1|Methyl 2-isothiocyanatobenzoate|98%
Brand: Ambeed
SKU: A827533
Rating: 92 (40 reviews)

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Quality Control of [ 16024-82-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 16024-82-1 ]

SDS Specification

Alternatived Products of [ 16024-82-1 ]

Product Details of [ 16024-82-1 ]

CAS No. :	16024-82-1	MDL No. :	MFCD00041062
Formula :	C₉H₇NO₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	UNXVHBOJSCWVCD-UHFFFAOYSA-N
M.W :	193.22	Pubchem ID :	85243
Synonyms :

Calculated chemistry of [ 16024-82-1 ] Expand+

Physicochemical Properties

Num. heavy atoms :	13
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.11
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	52.41
TPSA :	70.75 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.06 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.39
Log Po/w (XLOGP3) :	3.41
Log Po/w (WLOGP) :	2.21
Log Po/w (MLOGP) :	3.05
Log Po/w (SILICOS-IT) :	3.34
Consensus Log Po/w :	2.88

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.33
Solubility :	0.0904 mg/ml ; 0.000468 mol/l
Class :	Soluble
Log S (Ali) :	-4.58
Solubility :	0.00514 mg/ml ; 0.0000266 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-2.67
Solubility :	0.409 mg/ml ; 0.00212 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.95

Safety of [ 16024-82-1 ]

Signal Word:	Danger	Class:	8,6.1
Precautionary Statements:	P260-P264-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P311-P321-P363-P403+P233-P405-P501	UN#:	2922
Hazard Statements:	H314-H331-H302+H312	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 16024-82-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 16024-82-1 ]

[ 16024-82-1 ] Synthesis Path-Downstream 1~21

1
[ 16024-82-1 ]
[ 100-01-6 ]
[ 72176-80-8 ]

Reference： [1]Garin, Javier; Melendez, Enrique; Merchan, Francisco L.; Merino, Pedro; Orduna, Jesus; Tejero, Tomas [Journal of Heterocyclic Chemistry, 1991, vol. 28, # 2, p. 359 - 363]

2
[ 16024-82-1 ]
[ 765-30-0 ]
[ 146381-56-8 ]

Yield	Reaction Conditions	Operation in experiment
	In diethyl ether for 5h;

Reference： [1]Beyrich, Thorsten; Theiss [Pharmazie, 1998, vol. 53, # 12, p. 853 - 858]

3
[ 13754-19-3 ]
[ 16024-82-1 ]
3-(4-amino-pyrimidin-5-yl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one [ No CAS ]

Reference： [1]Arzneimittel-Forschung/Drug Research,2006,vol. 56,p. 665 - 670

4
[ 16024-82-1 ]
[ 56-06-4 ]
2,6-bis(4-oxo-2-thioxo-1,2-dihydro-quinazolin-3-yl)-4-hydroxy-pyrimidine [ No CAS ]

Reference： [1]Arzneimittel-Forschung/Drug Research,2006,vol. 56,p. 665 - 670

5
[ 16024-82-1 ]
[ 371-40-4 ]
[ 1547-15-5 ]

Yield	Reaction Conditions	Operation in experiment
80%	With triethylamine In 1,4-dioxane for 10h; Heating;

Reference： [1]Ghorab, Moustafa M.; Barakat, Saber El-Sayed; Saker, Helmy M.; Abd Rabo, Mahmoud M. [Arzneimittel-Forschung/Drug Research, 2006, vol. 56, # 9, p. 665 - 670]

6
[ 16024-82-1 ]
[ 1547-15-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85 percent / toluene / 4 h / Heating 2: dimethylformamide / Heating

Reference： [1]Ghorab, Moustafa M.; Barakat, Saber El-Sayed; Saker, Helmy M.; Abd Rabo, Mahmoud M. [Arzneimittel-Forschung/Drug Research, 2006, vol. 56, # 9, p. 665 - 670]

7
[ 16024-82-1 ]
[ 329080-15-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 57 percent / SnCl₄ / 16 h / 20 °C 2: 100 percent / hydrazine / 0.5 h / Heating

Reference： [1]Deck; Turner; Deck; Papadopoulos [Journal of Heterocyclic Chemistry, 2001, vol. 38, # 2, p. 343 - 347]

8
[ 16024-82-1 ]
[ 19062-39-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 79 percent / 16 h / Heating 2: 100 percent / hydrazine / ethanol / 3 h / Heating
	Multi-step reaction with 3 steps 1: 79 percent / 16 h / Heating 2: 93 percent / hydrazine / ethanol / 96 h / Ambient temperature 3: 53 percent / hydrazine / ethanol / 2.5 h / Heating

Reference： [1]Dean, William D.; Papadopoulos, Eleftherios P. [Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 1117 - 1124]
[2]Dean, William D.; Papadopoulos, Eleftherios P. [Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 1117 - 1124]

9
[ 16024-82-1 ]
[ 60421-23-0 ]
[ 1033693-52-5 ]

Yield	Reaction Conditions	Operation in experiment
64%	With triethylamine; In methanol; at 20℃; for 20h;	EXAMPLE A1; 1'-[4-(4-methylpiperazin-1-yl)benzyl]-2'H-spiro[cyclopentane-1,3'-imidazo[2,1-b]quinazoline]-2',5'(1'H)-dione hydrochloride Stage 1: methyl 1-(4-oxo-2-thioxo-1,4-dihydroquinazolin-3(2H)-yl) cyclopentane carboxylateA mixture of <strong>[60421-23-0]methyl 1-aminocyclopentanecarboxylate hydrochloride</strong> (1 g), methyl 2-isothiocyanatobenzoate (1.18 g) and triethylamine (15 mL) in methanol (60 ml) is stirred at ambient temperature for 20 hours then concentrated under reduced pressure at 40 C. Dichloromethane and water are added to the solid obtained. After decantation and extractions, the combined organic phases are washed with salt water, dried over Na2SO4 then concentrated under reduced pressure at 40 C. Purification by flash chromatography on silica gel (eluent: heptane/ethyl acetate 7:3 to 6:4) produces the expected compound in the form of powder (1.08 g, 64% yield).MS/LC: calculated MM=304.4; m/z=305.2 (MH+)NMR (1H, 400 MHz, DMSO-d6): delta 1.76-1.95 (m, 6H), 2.07 (m, 2H), 3.73 (s, 3H), 7.42 (AB, 1H), 7.60 (m, 1H), 7.74 (m, 1H), 7.99 (AB, 1H), 10.8 (s, 1H).

Reference： [1]Patent: US2010/144714,2010,A1 .Location in patent: Page/Page column 5

10
[ 16024-82-1 ]
[ 144-80-9 ]
[ 1221119-39-6 ]

Reference： [1]Arzneimittel-Forschung/Drug Research,2010,vol. 60,p. 87 - 95

11
[ 16024-82-1 ]
[ 51940-44-4 ]
[ 1206482-71-4 ]

Yield	Reaction Conditions	Operation in experiment
59%	With triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;

Reference： [1]Location in patent: experimental part Hoeglund, Adrienne B.; Bostic, Heidi E.; Howard, Angela L.; Wanjala, Irene W.; Best, Michael D.; Baker, Daniel L.; Parrill, Abby L. [Journal of Medicinal Chemistry, 2010, vol. 53, # 3, p. 1056 - 1066]

12
[ 127-79-7 ]
[ 16024-82-1 ]
[ 1429294-11-0 ]

Reference： [1]Archives of Pharmacal Research,2013,vol. 36,p. 660 - 670

13
[ 16024-82-1 ]
[ 526-08-9 ]
methyl 2-(3-(4-(N-(1-phenyl-1H-pyrazol-5-yl)sulfamoyl)phenyl)thioureido)benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	In ethanol; at 20℃; for 5.0h;	A mixtureof compound 2 (1.93 g, 0.01 mole) and 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide (3.14 g, 0.01 mole) in absolute ethanol (30 mL) was stirred at room temperature for 5 h. The reaction mixture was poured onto ice water and the solid obtained was recrystallized from dioxane to give 3. Yield% 88; m.p. 322.9 C; IR (KBr, nmax, Cm-1): 3448, 3275(NH),3039 (CH arom.), 2977, 2863 (CH aliph.), 1662 (C=O), 1620(C=N), 1342, 1168 (SO2), 1261 (C=S). 1H NMR spectrum in(DMSO-d6): 4.21 [s, 3H, OCH3], 6.60, 7.64 [2d, 2H, 2CHpyrazole, J = 7.33 Hz], 7.08- 8.12 [m, 13H, Ar-H], 11.46 [s,1H, SO2NH, D2O-exchangeable], 12.95 [s, 2H, 2NH, D2O exchangeable].13C NMR spectrum (in DMSO-d6): 52.4, 95.6,121.3 (2), 121.8, 127.9 (2), 128.5 (2), 129.0 (2), 131.4, 132.6,134.3, 137.8, 139.6, 141.2, 141.8, 144.9, 168.1, 181.2. Anal.Calc. for C24H21N5O4S2 (508): C, 56.79; H, 4.17; N, 13.80;found: C, 56.42; H, 4.34; N, 13.49.

Reference： [1]Asian Journal of Chemistry,2014,vol. 26,p. 8501 - 8504

14
[ 16024-82-1 ]
[ 526-08-9 ]
4-(4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With triethylamine; In ethanol; for 18.0h;Reflux;	A mixture of compound 2 (1.93 g, 0.01 mole) and 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide (3.14 g, 0.01 mole) in absolute ethanol (30 mL) containing a catalytic amount of triethylamine was refluxed for 18 h. The reaction mixture was cooled and poured onto ice water and the solid obtained was recrystallized from dioxane to give 4. Yield % 90; m.p. 300.4 C; IR (KBr, nmax, Cm-1): 3307, 3210(NH), 3088 (CH arom.), 1688 (C=O), 1610 (C=N), 1365, 1155(SO2), 1272 (C=S). 1H NMR spectrum (in DMSO-d6): 6.44,7.41 [2d, 2H, 2CH pyrazole, J = 6.97 Hz], 7.05-8.23 [m, 13H,Ar-H], 9.35 [s, 1H, NH, D2O-exchangeable], 11.44 [s, 1H,SO2NH, D2O-exchangeable]. 13C NMR spectrum (in DMSOd6):91.7, 119.8 (2), 120.6 (2), 122.7, 124.6, 125.1, 126.8 (2),127.6, 127.9, 128.5 (2), 130.6, 134.1, 134.7, 140.4, 141.3,141.9, 144.8, 162.7, 187.3. Anal. Calc. for C23H17N5O3S2 (476):C, 58.09; H, 3.60; N, 14.73; found: C, 58.32; H, 3.31; N, 14.51.

Reference： [1]Asian Journal of Chemistry,2014,vol. 26,p. 8501 - 8504

15
[ 16024-82-1 ]
[ 122-11-2 ]
[ 1675217-77-2 ]

Yield	Reaction Conditions	Operation in experiment
84%	With triethylamine In ethanol for 15h; Reflux;	Synthesis of N-(2,6-dimethoxypyrimidin-4-yl)-4-(4-oxo-2-thioxo-1,2-dihydro-quinazolin-3(4H)-yl)benzenesulfonamide (5) A mixture of compound 2 (1.93 g, 0.01 mole) and 4-amino-N-(3,5-dimethoxy-phenyl)benzenesulfonamide (3.08 g, 0.01 mole) in absolute ethanol (30 mL) containing a catalytic amount of triethylamine was refluxed for 15 h. The reaction mixture was cooled and poured onto ice water and the solid obtained was recrystallized from DMF/ EtOH to give 5. Yield % 84; m.p. 219.1 °C; IR (KBr, nmax, Cm-1): 3216, 3194(NH), 3065 (CH arom.), 1691 (C=O), 1622 (C=N), 1357, 1163(SO2), 1265 (C=S). 1H NMR spectrum (in DMSO-d6): 3.62,3.74 [2s, 6H, 2OCH3], 6.26 [s, 1H, CH pyrimidine], 7.13-8.28[m, 8H, Ar-H], 8.93 [s, 1H, NH, D2O-exchangeable], 10.90[s, 1H, SO2NH, D2O-exchangeable]. 13C NMR spectrum (inDMSO-d6): 56.6 (2), 84.3, 120.8 (2), 122.6, 125.7, 126.3 (2),126.9, 127.8, 129.8, 134.6, 134.9, 138.4, 161.3, 161.7, 163.2,174.1, 187.8. Anal. Calc. for C20H17N5O5S2 (472): C, 50. 95;H, 3.63; N, 14.85; found: C, 50.66; H, 3.29; N, 14.49.

Reference： [1]Ghorab, Mostafa M.; Higgins, Maureen; Dinkova-Kostova, Albena T.; Alsaid, Mansour S.; Shahat, Abdelaaty A. [Asian Journal of Chemistry, 2014, vol. 26, # 24, p. 8501 - 8504]

16
[ 16024-82-1 ]
[ 536-90-3 ]
[ 56671-19-3 ]

Yield	Reaction Conditions	Operation in experiment
91%	With triethylamine In 1,4-dioxane at 20℃; for 2h;	3-Phenyl-2-thioxoquinazoline-4-one (10a) General procedure: To a solution of methyl 2-isothiocyanatobenzoate (46.7 mg, 0.242 mmol) and aniline (22.1 μL, 0.242 mmol) in 1,4-dioxane (2.0 mL) was added Et3N (37.4 μL, 0.242 mmol). The mixture was stirred at r.t. for 2 h, and the precipitated white solid was collected by filtration, washed with n-hexane, and recrystallized from CHCl3 and n-hexane to afford the title compound (47.0 mg, 0.185 mmol, 76%) as a white solid.

Reference： [1]Numadate, Akiyoshi; Mita, Yusuke; Matsumoto, Yotaro; Fujii, Shinya; Hashimoto, Yuichi [Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988]

17
[ 16024-82-1 ]
[ 7251-09-4 ]
3-(4-cyano-3-methoxyphenyl)-2-thioxoquinazoline-4-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16%	With triethylamine; In 1,4-dioxane; at 20℃; for 10h;	To a solution of methyl 2-isothiocyanatobenzoate (98.8 mg, 0.511 mmol) and 14b (74.0 mg, 0.499 mmol) in dioxane(2.0 mL) was added Et3N (80 muL, mmol). The mixture was stirred at r.t. for 10 h, and the precipitated white solid was collected by filtration and washed with n-hexane to give the title compound (18.9 mg, 0.0818 mmol, 16%) as a white solid. mp>300C. 1H-NMR (500 MHz, DMSO-d6) delta: 7.98 (1H, dd, J=1.2, 8.0 Hz), 7.88 (1H, d, J=8.1 Hz), 7.83-7.80 (1H, m), 7.47 (1H, d, J=8.0 Hz), 7.39-7.36 (2H, m), 7.12 (1H, dd, J=1.7, 8.0 Hz), 3.89 (3H, s). 13C-NMR (125 MHz, DMSO-d6) delta: 175.30, 161.55, 159.60, 145.42, 139.87, 135.73, 133.91, 127.33, 124.40, 122.48, 116.24, 116.09, 115.94, 113.78, 99.97, 56.63. FAB-MS m/z 310 (MH+). Anal. Calcd for C16H11N3O2S: C, 62.12; H, 3.58; N, 13.58. Found: C, 61.98; H, 3.66; N, 13.47

Reference： [1]Chemical and Pharmaceutical Bulletin,2014,vol. 62,p. 979 - 988

18
[ 16024-82-1 ]
[ 95-84-1 ]
9-methyl-12H-benzo[4,5]oxazolo[2,3-b]quinazolin-12-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	Stage #1: methyl 2-isothiocyanatobenzoate; 3-amino-4-hydroxytoluene With potassium carbonate In dimethyl sulfoxide at 25℃; for 0.5h; Green chemistry; Stage #2: With potassium metaperiodate In water; dimethyl sulfoxide at 80℃; Green chemistry;	Fused Tetracyclic Quinazolinones 7; General Procedure General procedure: Following the above described general procedure for the synthesis of benzazoles, methyl 2-isothiocyanatobenzoate (2m; 0.0521 g, 0.27mmol) was reacted with amino derivative 1. After completion of thereaction, the mixture was treated with CH2Cl2 (2 mL). The resulting precipitate was filtered, washed with CH2Cl2, and oven-dried at 80 °C.

Reference： [1]Duangkamol, Chuthamat; Pattarawarapan, Mookda; Phakhodee, Wong [Synthesis, 2020, vol. 52, # 13, p. 1981 - 1990]

19
[ 16024-82-1 ]
[ 63631-09-4 ]
N-(2-methoxyphenyl)-5-oxo-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	With sulfur; triethylamine In N,N-dimethyl-formamide at 50℃;

Reference： [1]Liang, Xuewu; Sun, Chenxia; Li, Chunpu; Yu, Haolan; Wei, Xiaohui; Liu, Xuyi; Bao, Wei; Shi, Yuqiang; Sun, Xiaochen; Khamrakulov, Mirzadavlat; Yang, Chenghua; Liu, Hong [Journal of Medicinal Chemistry, 2021, vol. 64, # 13, p. 9217 - 9237]

20
[ 16024-82-1 ]
[ 113604-07-2 ]
N-(2,5-dimethoxyphenyl)-5-oxo-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%	With sulfur; triethylamine In N,N-dimethyl-formamide at 50℃;

21
[ 15386-80-8 ]
[ 16024-82-1 ]
N-(3,4-dichlorophenyl)-5-oxo-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55%	With sulfur; triethylamine In N,N-dimethyl-formamide at 50℃;

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Isomers

Technical Information

• Benzylic Oxidation • Birch Reduction • Birch Reduction of Benzene • Blanc Chloromethylation • Complete Benzylic Oxidations of Alkyl Chains • Complete Benzylic Oxidations of Alkyl Chains • Conversion of Amino with Nitro • Deprotonation of Methylbenzene • Directing Electron-Donating Effects of Alkyl • Electrophilic Chloromethylation of Polystyrene • Friedel-Crafts Alkylation of Benzene with Acyl Chlorides • Friedel-Crafts Alkylation of Benzene with Carboxylic Anhydrides • Friedel-Crafts Alkylation Using Alkenes • Friedel-Crafts Alkylations of Benzene Using Alkenes • Friedel-Crafts Alkylations Using Alcohols • Friedel-Crafts Reaction • Groups that Withdraw Electrons Inductively Are Deactivating and Meta Directing • Halogenation of Benzene • Hydrogenation to Cyclohexane • Hydrogenolysis of Benzyl Ether • Nitration of Benzene • Nucleophilic Aromatic Substitution • Nucleophilic Aromatic Substitution with Amine • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Preparation of Alkylbenzene • Reactions of Benzene and Substituted Benzenes • Reductive Removal of a Diazonium Group • Reverse Sulfonation——Hydrolysis • Sulfonation of Benzene • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Nitro Group Conver to the Amino Function • Vilsmeier-Haack Reaction

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P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 16024-82-1 ] {[proInfo.proName]}

Quality Control of [ 16024-82-1 ]

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[ 16024-82-1 ] Synthesis Path-Downstream 1~21

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