[ CAS No. 16066-09-4 ] {[proInfo.proName]}

Name: 16066-09-4|1,1,1,3,5,7,7,7-Octamethyltetrasiloxane|98%
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Quality Control of [ 16066-09-4 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 16066-09-4 ]

CAS No. :	16066-09-4	MDL No. :	MFCD00053664
Formula :	C₈H₂₆O₃Si₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OHSYWAVRSCQMHG-UHFFFAOYSA-N
M.W :	282.63	Pubchem ID :	6327318
Synonyms :

Safety of [ 16066-09-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501	UN#:	N/A
Hazard Statements:	H227-H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 16066-09-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 16066-09-4 ]
Downstream synthetic route of [ 16066-09-4 ]

[ 16066-09-4 ] Synthesis Path-Upstream 1~3

1
[ 75-54-7 ]
[ 107-46-0 ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 17478-13-6 ]
[ 17998-54-8 ]

Reference： [1] Journal of the American Chemical Society, [2] Journal of the American Chemical Society, 1946, vol. 68, p. 962 - 963
[3] , Gmelin Handbook: Si: MVol.C, 105, page 289 - 291,
[4] C. A., 1952, p. 7820
[5] C. A., 1950, p. 7866
[6] C. A., 1952, p. 7820
[7] C. A., 1950, p. 7866
[8] C. A., 1952, p. 7820
[9] C. A., 1950, p. 7866

2
[ 75-54-7 ]
[ 75-77-4 ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 2370-88-9 ]
[ 6166-86-5 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1991, vol. 61, # 6.2, p. 1257 - 1261[2] Zhurnal Obshchei Khimii, 1991, vol. 61, # 6, p. 1378 - 1383

3
[ 75-54-7 ]
[ 75-77-4 ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 2370-88-9 ]
[ 17478-13-6 ]
[ 6166-86-5 ]
[ 17998-54-8 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1991, vol. 61, # 6.2, p. 1257 - 1261[2] Zhurnal Obshchei Khimii, 1991, vol. 61, # 6, p. 1378 - 1383

[ 16066-09-4 ] Synthesis Path-Downstream 1~31

1
[ 75-54-7 ]
[ 75-77-4 ]
[ 16066-09-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1956,vol. 29,p. 547
[2]Journal of general chemistry of the USSR,1968,vol. 38,p. 174 - 176
Zhurnal Obshchei Khimii,1968,vol. 38,p. 175 - 178

2
[ 16066-09-4 ]
[ 5592-24-5 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1965,vol. 38,p. 2182 - 2186

3
[ 75-54-7 ]
[ 75-77-4 ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 2370-88-9 ]
[ 17478-13-6 ]
[ 6166-86-5 ]
[ 17998-54-8 ]

Reference： [1]Journal of general chemistry of the USSR,1991,vol. 61,p. 1257 - 1261
Zhurnal Obshchei Khimii,1991,vol. 61,p. 1378 - 1383

4
[ 75-54-7 ]
[ 75-77-4 ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 2370-88-9 ]
[ 6166-86-5 ]

Reference： [1]Journal of general chemistry of the USSR,1991,vol. 61,p. 1257 - 1261
Zhurnal Obshchei Khimii,1991,vol. 61,p. 1378 - 1383

5
[ 75-54-7 ]
[ 75-77-4 ]
[ 16066-09-4 ]
[ 2370-88-9 ]
[ 17478-13-6 ]
[ 6166-86-5 ]

Reference： [1]Journal of general chemistry of the USSR,1991,vol. 61,p. 1257 - 1261
Zhurnal Obshchei Khimii,1991,vol. 61,p. 1378 - 1383
[2]Journal of general chemistry of the USSR,1991,vol. 61,p. 1257 - 1261
Zhurnal Obshchei Khimii,1991,vol. 61,p. 1378 - 1383

6
[ 75-54-7 ]
[ 107-46-0 ]
[ 16066-09-4 ]

Reference： [1]Journal of Organometallic Chemistry,1986,vol. 314,p. 39 - 46

7
[ 16066-09-4 ]
[ 100045-15-6 ]

Yield	Reaction Conditions	Operation in experiment
84%	With trichloroisocyanuric acid; In tetrahydrofuran; at -20℃; for 0.25h;Inert atmosphere; Schlenk technique;	General procedure: Chlorination where all Si-H bonds had to be chlorinated were performed in THF, TCCA was used in excess (1 eq. TCCA / 1 eq.siloxane). A flask was filled with educt and THF and cooled down to -20C (20 mlTHF/g educt). TCCA was added in small portions, under intense stirring. After TCCAa ddition was completed, stirring was continued for 15 minutes, afterwards, the cooling bath was removed and the solution was allowed to come to room temperature. Varying siloxane chain lengths, substituents or Si-H bond positions affected the method in whichcompounds were isolated and characterized. THF and unreacted TCCA had to be removed soon after the reactions were completed, otherwise product degeneration was observed after a few days.

Reference： [1]Journal of Organometallic Chemistry,2018,vol. 875,p. 1 - 4
[2]Journal of Organometallic Chemistry,1986,vol. 314,p. 39 - 46

8
[ 16066-09-4 ]
[ 75507-25-4 ]
C₃₀H₆₆O₁₅Si₄ [ No CAS ]

Reference： [1]Tetrahedron Letters,1999,vol. 40,p. 4123 - 4126

9
[ 75-54-7 ]
[ 110-54-3 ]
[ 107-46-0 ]
ice [ No CAS ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 17478-13-6 ]
[ 17998-54-8 ]

Reference： [1]Journal of the American Chemical Society,1946,vol. 68,p. 963

12
[ 16066-09-4 ]
[ 64-19-7 ]
C₁₂H₃₀O₇Si₄ [ No CAS ]

Reference： [1]Organic Letters,2000,vol. 2,p. 1027 - 1029

13
Me₃SiO(HMeSiO)50SiMe₃ [ No CAS ]
[ 107-46-0 ]
[ 16066-09-4 ]

Yield	Reaction Conditions	Operation in experiment
	With trimethylsilyl trifluoromethanesulfonate; for 24h;	(MF XVII) is the reaction product of the hydrosilylation between the equilibrate M(DH)2M and a 30% molar excess of an allyl started polyether with the formula of CH2CHCH2-O-(CH2CH2O)3.5-H. A nitrogen blanketed glass reactor at atmospheric pressure, which was equipped with a temperature probe, an agitator, a condenser and a nitrogen inlet, was charged with 30.0 gms of polysiloxane hydride of the formula equilibrate M(DH)2M containing 153 cc/g of active hydrogen, 57.60 g of the polyether with an allyl content of 18.96 weight percent and 102 microliters of dibutylethanolamine as a buffer. The reaction mixture (heterogeneous) was heated to 72 C. and platinum catalyst was introduced as 88 microliters of a 3.3% solution of chloroplatinic acid in ethanol, corresponding to 10 ppm of platinum. The reaction was exothermic and the reactor temperature rose to 99 C. within 40 minutes. The reaction was complete (i.e., the equilibrate SiH was consumed) after 2 hours. The copolymer was allowed to cool in the reactor for 30 minutes and then removed. The equilibrate M(DH)2M was obtained by adding 108.4 g of MM and 91.6 g of MD50HM (or L31) with 163 microliters of trimethylsilyl trifluoromethanesulfonate. The glass flask was put on a rolling shaker for 24 hours to equilibrate and the next day 272 microliters of dibutylethanolamine was added for neutralization. The mixture was shaken on the rollers of the rolling shaker for 1 hour. There were some droplets on the walls of the glass so 3 spatulas of NaHCO3 were added to further neutralize the mixture and then the mixture was filtered on a folded filter paper.

Reference： [1]Patent: US2007/249502,2007,A1 .Location in patent: Page/Page column 18

14
[ 16066-09-4 ]
[ 108909-17-7 ]

Reference： [1]Journal of Organometallic Chemistry,1986,vol. 314,p. 39 - 46

15
[ 75-54-7 ]
[ 107-46-0 ]
[ 1873-88-7 ]
[ 16066-09-4 ]
[ 17478-13-6 ]
[ 17998-54-8 ]

Reference： [1]Journal of the American Chemical Society,1946,vol. 68,p. 962 - 963
[2]Patent: US2595890,1952,A
C. A.,1952,p. 7820
[3]Patent: US2595890,1952,A
C. A.,1952,p. 7820

16
[ 59246-46-7 ]
[ 16066-09-4 ]
[ 84330-62-1 ]

Reference： [1]Journal of Organometallic Chemistry,1982,vol. 238,p. 87 - 98

17
[ 16066-09-4 ]
[ 5895-30-7 ]
[ 1293367-39-1 ]

Yield	Reaction Conditions	Operation in experiment
93.1%		A 500 ml round bottomed glass flask equipped with a 100 ml. addition funnel was prepared. Pd/C (0.16 g), water (1.9 g, 0.106 mol) and THF (175 ml) were added to the flask. 3H, 5H-octamethyltetrasiloxane (10.0 g, 0.035 mol) and THF (75 ml) were added to the addition funnel. The solution was added slowly drop- wise into the flask and after complete addition the reaction was stirred at room temperature for 6 hours. The solution was filtered through acid washed Celite to remove Pd/C. A 3 L round bottomed glass flask with a 250 ml addition funnel was prepared. The previously synthesized asymmetric linear siloxane (b) (56.4 g, 0.178 mol), triethylamine (27.8 g, 0.275 mol) and diethyl ether (700 ml) were added to the flask under positive N2 pressure. The filtrate from the Celite filtration was added into the addition funnel and dropped slowly into the flask at 0 C. As soon as the addition was complete the ice-bath was removed and the suspension was stirred overnight at room temperature. Water (1 L) was added to the solution to quench excess amounts of asymmetric linear siloxane before the aqueous and organic layers were separated. The organic portion was washed three times with water and dried over magnesium sulfate. The magnesium sulfate was removed by gravity filtration before the solution was reduced in vacuo. Distillation using a Kugelrohr apparatus at 170 C and at 2 Torr was carried out to remove byproducts as well as impurities. 28.9 g of a colorless liquid was obtained (93.1% yield). lH NMR (CDC13): δ = 4.68 (m, 2H), 0.17 (d, J = 2.80 Hz, 12H) 0.08 (d, J = 0.40 Hz, 18H), 0.07 (d, J = 1.20Hz, 12H), 0.06 (s, 12H), 0.05 (s, 12H), 0.03 (s, 6H). 13C NMR (CDC13): δ = 1.67, 1.04, 0.96, 0.85, 0.69, -2.27. 29Si{'H} NMR (CDC13): δ = 7.70, -7.00, 19.95, -21.82, -22.08, -66.98. 29Si NMR (CDC13): 6 = 7.70, -7.00 (JSiH = 203.68Hz), -19.94, -21.82, -22.08, -66.98. MALDI-MASS: m/z = 897.235 (C24H74OnSi12Na+1).

Reference： [1]Patent: WO2011/103176,2011,A1 .Location in patent: Page/Page column 17; 18

18
[ 766-98-3 ]
[ 16066-09-4 ]
3-(4-fluorophenyl)-2,5-dimethyl-2,5-bis((trimethylsilyl)oxy)-2,5-dihydro-1,2,5-oxadisilole [ No CAS ]
3-(4-fluorophenyl)-2,5-dimethyl-2,5-bis((trimethylsilyl)oxy)-2,5-dihydro-1,2,5-oxadisilole [ No CAS ]