Home Cart 0 Sign in  

[ CAS No. 1609373-99-0 ]

{[proInfo.proName]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 1609373-99-0
Chemical Structure| 1609373-99-0
Structure of 1609373-99-0 *Storage: {[proInfo.prStorage]}

Quality Control of [ 1609373-99-0 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 1609373-99-0 ]

SDS

Product Details of [ 1609373-99-0 ]

CAS No. :1609373-99-0MDL No. :MFCD31558346
Formula :C17H12N2OBoiling Point :-
Linear Structure Formula :-InChI Key :N/A
M.W :260.29Pubchem ID :86718307
Synonyms :

Computed Properties of [ 1609373-99-0 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1609373-99-0 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1609373-99-0 ]

  • Downstream synthetic route of [ 1609373-99-0 ]

[ 1609373-99-0 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 1609373-99-0 ]
  • C28H40IrN2O2(1+)*CF3O3S(1-) [ No CAS ]
  • C43H43IrN4O [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% In 2-ethoxy-ethanol; N,N-dimethyl-formamide; at 130℃; for 18h; Intermediate I-4 (4.0 g, 5.5 mmol) and ligand L-2 (4.1 g, 16.6 mmol)Dissolved in DMF (100 mL) and 2-ethoxyethanol (100 mL)The mixture was heated at 130 C for 18 hours.After evaporating the solvent, the crude product contains 65-100%The hexane eluent of dichloromethane is purified by column.GD-004 (2.8 g, yield: 61%) was obtained.
  • 2
  • [ 1609373-99-0 ]
  • C26H36IrN2O2(1+)*CF3O3S(1-) [ No CAS ]
  • C41H39IrN4O [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% In 2-ethoxy-ethanol; N,N-dimethyl-formamide; at 130℃; for 18h; Intermediate I-3 (3.9 g, 5.2 mmol) and ligand L-2 (3.8 g, 15.6 mmol)Dissolved in DMF (100 mL) and 2-ethoxyethanol (100 mL)The mixture was heated at 130 C for 18 hours.After evaporating the solvent, the crude product contains 65-100%The hexane eluent of dichloromethane is purified by column.GD-003 (2.5 g, yield: 60%) was obtained.
  • 3
  • [ 1609373-99-0 ]
  • C24H32IrN2O2(1+)*CF3O3S(1-) [ No CAS ]
  • C39H35IrN4O [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% In 2-ethoxy-ethanol; N,N-dimethyl-formamide; at 130℃; for 18h; Intermediate I-2 (4.0 g, 5.5 mmol) and ligand L-2 (4.3 g, 16.6 mmol) were dissolved in a mixed solvent of DMF (100 mL) and 2-ethoxyethanol (100 mL) at 130 C Heat for 18 hours. After evaporating the solvent, the crude product was purified by column chromatography eluting with 65-100% methylene chloride to afford GD-001 (2.4 g, yield: 58%).
  • 4
  • [ 1609373-99-0 ]
  • C43H28(2)H15IrN4O [ No CAS ]
  • 5
  • [ 1609373-99-0 ]
  • C41H30(2)H9IrN4O [ No CAS ]
  • 6
  • [ 109-04-6 ]
  • [ 1609374-04-0 ]
  • [ 1609373-99-0 ]
YieldReaction ConditionsOperation in experiment
80% Under the protection of nitrogen,Add intermediate I-1 (10 g, 32.3 mmol) to a three-neck bottle.2-bromopyridine (6.1 g, 38.8 mmol), 2M-potassium carbonate (80 mL)Dissolved in tetrahydrofuran (80 mL). Nitrogen replacement for 30 minutes,The catalyst tetrakistriphenylphosphine palladium (3 mol%) was added. The reaction system was warmed to 80 C and stirred under reflux for 12 hours.After cooling to room temperature, the reaction mixture was quenched with water and ethyl acetate and brine. Wash two to three times with saturated brine and take the organic phase.The organic phase was dried over anhydrous magnesium sulfate and concentrated.Separation and purification by silica gel column to obtain ligand L-2(6.7 g, yield: 80%).
  • 7
  • [ 1609373-98-9 ]
  • [ 1609373-99-0 ]
  • 8
  • [ 1609373-99-0 ]
  • [ 1609374-00-6 ]
YieldReaction ConditionsOperation in experiment
80% With sodium ethanolate; In ethyl [2]alcohol; for 72h;Reflux; A solution of [1609373-99-0]2-methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine (6.3 g, 24.20 mmol) and sodium ethoxide (3.29grams, 48.4 mmol) in ethanol-D (100 ml) was refluxed for 72 h. The solvent was evaporated and the residue waspartitioned between ethyl acetate and water. The organic phase was isolated, dried over sodium sulfate and evaporated.Upon evaporation of the solvent, the residue was purified by column chromatography on silica gel with 0-15% ethylacetate in dichloromethane to yield 5.1 g (80%) of desired compound as a white solid.
80% With dimethylsulfoxide-d6; sodium t-butanolate; at 80℃; for 12h; A solution of the ligand L-2 (10 g, 38.4 mmol) and NaOtBu (1.8 g, 19.2 mmol) in DMSO-d6 (50 mL) was refluxed at 80 C for 12 hours.After the reaction was quenched by D2O (50 mL),It was extracted with saturated brine and EtOAc. Combined organic layerDry and filter through celite. The filtrate is then concentrated and distilled.Ligand L-7 (8.1 g, yield: 80%) was obtained.
  • 9
  • [ 1609373-99-0 ]
  • [ 1609368-32-2 ]
  • 10
  • [ 1609373-99-0 ]
  • [ 1609368-31-1 ]
Historical Records

Related Parent Nucleus of
[ 1609373-99-0 ]

Other Aromatic Heterocycles

Chemical Structure| 39853-77-5

[ 39853-77-5 ]

6-Methylfuro[2,3-b]pyridine

Similarity: 0.71