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Chemical Structure| 1612148-85-2 Chemical Structure| 1612148-85-2

Structure of 1612148-85-2

Chemical Structure| 1612148-85-2

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Product Details of [ 1612148-85-2 ]

CAS No. :1612148-85-2
Formula : C18H15FN2O4
M.W : 342.32
SMILES Code : O=C(C1=NN(C2=CC=C(F)C=C2)C(C3=C(OC)C=CC=C3OC)=C1)O
MDL No. :MFCD30471982

Safety of [ 1612148-85-2 ]

Application In Synthesis of [ 1612148-85-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1612148-85-2 ]

[ 1612148-85-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1612148-85-2 ]
  • [ 63203-48-5 ]
  • [ 1612148-62-5 ]
  • 2
  • [ 1612148-85-2 ]
  • [ 63203-48-5 ]
  • ethyl 1-(5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamido)cyclohexanecarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% 5-(2,6-Dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid (2) (150 mg, 0.438 mmol) was dissolved in THF (7 mL). To the solution was added HATU (167 mg, 0.438 mmol) and triethylamine (0.30 mL, 2.19 mmol). The resulting mixture was stirred at room temperature for 20 min. Ethyl 1-aminocyclohexane-1-carboxylate hydrochloride (100 mg, 0.482 mmol) was added and stirred at room temperature for 2 h. THF was evaporated in vacuo, water was added to the residue and the aqueous layer was extracted with CH2Cl2 (3 * 20 mL). The combined organic layers were washed with water, brine and then dried with Na2SO4 .The solvent was evaporated in vacuo to give the crude residue. The residue was purified by silica gel flash chromatography (EtOAc/Hex) to give (S)-methyl 6-((tert-butoxycarbonyl)amino)-2-(5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamido)hexanoate as white solid (145 mg, 67%).
 

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