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Chemical Structure| 1612287-20-3 Chemical Structure| 1612287-20-3

Structure of 1612287-20-3

Chemical Structure| 1612287-20-3

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Product Details of [ 1612287-20-3 ]

CAS No. :1612287-20-3
Formula : C7H4BrClN2
M.W : 231.48
SMILES Code : ClC1=CC2=CC(Br)=CN=C2N1
MDL No. :MFCD32640875

Safety of [ 1612287-20-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 1612287-20-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1612287-20-3 ]

[ 1612287-20-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1612287-20-3 ]
  • [ 503184-35-8 ]
  • [ 1612287-22-5 ]
YieldReaction ConditionsOperation in experiment
62% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; In 1,4-dioxane; water; at 100℃; for 6h;Schlenk technique; Inert atmosphere; An oven dried resealable Schlenk tube was charged with 5-bromo-2-chloro-1H-pyrrolo[2,3-b]pyridine (Preparation 1c, 0.5 g, 2.07 mmol), <strong>[503184-35-8](6-methoxy-4-methylpyridin-3-yl)boronic acid</strong> (Preparation 2, 0.35 g, 2.08 mmol), cesium carbonate (2.027 g, 6.22 mmol), 5.5 ml dioxane and 5.5 ml water. The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon, and 1,1'-bis(diphenylphosphino)ferrocene-palladium(II) dichloride dichloromethane complex (0.085 g, 0.10 mmol) was added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and placed in an oil bath at 100 C. After 6h, the mixture was cooled and the solvent was removed in vacuo. Water was added and product was extracted with dichloromethane and organic layer was dried (Na2SO4). The residue was purified by flash chromatography (10%, dichloromethane-methanol) to give the title compound (0.353 g, 62% yield) as a solid. LRMS (m/z):274 (M+1)+.
 

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