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Chemical Structure| 161416-98-4 Chemical Structure| 161416-98-4

Structure of A85380
CAS No.: 161416-98-4

Chemical Structure| 161416-98-4

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Product Details of [ 161416-98-4 ]

CAS No. :161416-98-4
Formula : C9H12N2O
M.W : 164.20
SMILES Code : C1(OC[C@H]2NCC2)=CC=CN=C1
MDL No. :MFCD00672647

Safety of [ 161416-98-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 161416-98-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 161416-98-4 ]

[ 161416-98-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 132898-96-5 ]
  • [ 161416-98-4 ]
  • [ 1304773-22-5 ]
YieldReaction ConditionsOperation in experiment
1.27 g With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20℃;Inert atmosphere; General Procedure: To a solution of 4 (1.32 g, 5 mmol) in CH2Cl2 (10 mL), trifloroacetic acid (10 mL) was added at 0 oC. The mixture was stirred at 0 oC for 15 min. After evaporation of the solvent in vacuo, CH2Cl2 (15 mL) and triethylamine (2 mL) were added, then a solution of <strong>[132898-96-5]2,3-dioxoindoline-5-sulfonyl chloride</strong> (1.23g, 5mmol) in THF (25 mL) was added at 0 oC. The reaction mixture was stirred overnight at rt. Then the solvent was evaporated in vacuo, ethyl acetate (100 mL) was added, washed with water (50 mL x 2), saturated NaCl (50 mL), and dried over Na2SO4. After evaporation of the ethyl acetate, the crude product was purified by Flash column chromatograph with ethyl acetate to afford 1.27 g (68%) of 5.
 

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