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Chemical Structure| 1621165-22-7 Chemical Structure| 1621165-22-7

Structure of 1621165-22-7

Chemical Structure| 1621165-22-7

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Product Details of [ 1621165-22-7 ]

CAS No. :1621165-22-7
Formula : C11H21NO4
M.W : 231.29
SMILES Code : C(OC(C)(C)C)(=O)N1C[C@H](CO)OC[C@H]1C
MDL No. :MFCD23381159

Safety of [ 1621165-22-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1621165-22-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1621165-22-7 ]

[ 1621165-22-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1621165-22-7 ]
  • [ 4983-28-2 ]
  • (2R,5R)-tert-butyl 2-(((2-chloropyrimidin-5-yl)oxy)methyl)-5-methylmorpholine-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; for 12h; To a solution of (2R,5R)-tert-butyl 2-(hydroxymethyl)-5-methylmorpholine-4-carboxylate (1.2 g, 5.2 mmol) and <strong>[4983-28-2]2-chloropyrimidin-5-ol</strong> (1 g, 7.5 mmol), DIAD(1.5 g 7.5 mmol) in THF (30 mL) was added triphenylphosphine (2 g, 7.5 mmol) at 0 °C, then the reaction was stirred at room temperature for 12 hours. The reaction solution was evaporated to dryness and the residue was purified by flash column chromatography, eluting with ethyl acetate: petroleum ether = 1:3 to afford the title compound (0.52 g, 1.52 mmol, 29 percent yield). LCMS Method D RT= 1.54 min, ES+ve 287.9 (M-tBu+H).
 

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