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Chemical Structure| 1627722-97-7 Chemical Structure| 1627722-97-7

Structure of 1627722-97-7

Chemical Structure| 1627722-97-7

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Product Details of [ 1627722-97-7 ]

CAS No. :1627722-97-7
Formula : C14H19BN2O2
M.W : 258.12
SMILES Code : CC1(C)C(C)(C)OB(C2=NN(C)C3=C2C=CC=C3)O1
MDL No. :MFCD13182067
InChI Key :OZGVUTRIDUMWJT-UHFFFAOYSA-N
Pubchem ID :72219016

Safety of [ 1627722-97-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335-H317
Precautionary Statements:P261-P264-P270-P271-P272-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1627722-97-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1627722-97-7 ]

[ 1627722-97-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 163622-50-2 ]
  • [ 1627722-97-7 ]
  • C14H12N6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 90℃; for 12.0h; Dissolve 3-iodo-4-amino-1H-pyrrole [3,4-d] pyrimidine (294 mg, 1.13 mmol) in 2 mL (1: 3) of a mixed solvent of ethanol and DME, and then add 0.25 mL of saturated sodium carbonate Solution andN-methyl 2-azaindole-3-boronic acid pinacol ester (413 mg, 1.6 mmol). After the whole system was ventilated three times, tetrakis (triphenylphosphine) palladium (127 mg, 0.11 mmol) was added to the mixture, and then the whole system was heated to 90 C. under nitrogen and stirred for 12 hours. After the reaction was completed, filtration was performed with celite, and the obtained filtrate was washed three times with water and dichloromethane. The organic phase was subjected to rotary evaporation under reduced pressure to obtain a solid, which was separated by silica gel column chromatography (eluent was dichloromethane containing 1-2% methanol), and finally 234 mg (0.88 mmol) of the target compound was obtained as a pale green solid. Yield: 78%.
 

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Categories

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