163295-70-3|(3,5-Dichlorophenyl)methanesulfonyl chloride| Ambeed

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Quality Control of [ 163295-70-3 ] Purity: 97% SDS Specification

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Product Details of [ 163295-70-3 ]

CAS No. :	163295-70-3
Formula :	C₇H₅Cl₃O₂S
M.W :	259.54
SMILES Code :	O=S(CC1=CC(Cl)=CC(Cl)=C1)(Cl)=O
MDL No. :	MFCD01631928
InChI Key :	GZMJRPMBVICCFL-UHFFFAOYSA-N
Pubchem ID :	4993270

Safety of [ 163295-70-3 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314
Precautionary Statements:	P280-P305+P351+P338-P310
Class:	8
UN#:	3261
Packing Group:	Ⅱ

Application In Synthesis of [ 163295-70-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 163295-70-3 ]

[ 163295-70-3 ] Synthesis Path-Downstream 1~32

1
[ 163295-70-3 ]
[ 848072-17-3 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 1235 - 1238.
[2]Journal of Medicinal Chemistry,2019,vol. 62,p. 3088 - 3106.

2
[ 540522-69-8 ]
[ 163295-70-3 ]
[ 683812-95-5 ]

References: [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 1380 - 1400.

3
[ 163295-70-3 ]
4-{2-[5-chloro-2-(2-[(3,5-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoic acid [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 1380 - 1400.

4
[ 163295-70-3 ]
tert-butyl 4-(((3,5-dichlorobenzyl)sulfonyl)carbamoyl)piperidine-1-carboxylate [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 1235 - 1238.
[2]Journal of Medicinal Chemistry,2019,vol. 62,p. 3088 - 3106.

6
[ 540524-01-4 ]
[ 163295-70-3 ]
[ 540524-08-1 ]

Yield	Reaction Conditions	Operation in experiment
		Step 1: To 2-(1-Benzhydryl-6-chloro-1H-indol-2-yl)-ethylamine, Example 105 step 7 was added (3,5-dichloro-phenyl)-methanesulfonyl chloride according to the procedure in Example 105 Step 7 to generate N-[2-(1-benzhydryl-6-chloro-1H-indol-2-yl)-ethyl]-C-(3,5-dichloro-phenyl)-methanesulfonamide in quantitative yield.

References: [1]Patent: US2003/144282,2003,A1 .

7
[ 120-35-4 ]
[ 163295-70-3 ]
3-Phenylmethanesulfonylamino-4-methoxy-N-phenyl-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 250 4-Methoxy-3-phenylmethanesulfonylamino-N-phenyl-benzamide The title compound has been made using the procedure of Example 121, but using 3-amino-4-methoxy-N-phenyl benzamide and 3,5-dichlorobenzylsulfonyl chloride as starting materials, which are commercially available from Aldrich or Lancaster; m.p. 214-217 C.

References: [1]Patent: US6268387,2001,B1 .

8
[ 934292-09-8 ]
[ 163295-70-3 ]
[ 934292-10-1 ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; In acetonitrile; at 20℃;	D) (2S,4R)-2-(4-Bromo-benzyl)-4-(tert-butyl-dιmethyl-sιlanyloxy)-1-(3,5-dιchloro- phenylmethanesulfonyl)-pyrrolιdιne-2-carboxylιc acid methyl ester A compound of formula EPO <DP n="26"/>rTo a solution of 400 mg of (2S,4R)-2-(4-bromo-benzyl)-4-(tert-butyl-dιmethyl-sιlanyloxy)- pyrrolιdιne-2-carboxylιc acid methyl ester and 1 5 g of 4-dιmethylamιno pyridine (DMAP, Steglich base) in 20 ml of CH3CN are added 600 mg of 2,5-dιchlorophenyl methanesulfonyl chloride at rt and the mixture obtained is stirred at rt To the mixture obtained EtOAc and a saturated aqueous NAHCO3-solutιon is added, the phases obtained are separated and the organic layer is washed, dried, and solvent is evaporated The evaporation residue obtained is subjected to chromatography (2S,4R)-2-(4-Bromo-benzyl)-4-(tert-butyl-dιmethyl- sιlanyloxy)-1-(3,5-dιchloro-phenylmethanesulfonyl)-pyrrolιdιne-2-carboxylιc acid methyl ester is obtained in the fornm of a slightly yellow oilMS 673 (MNa+), 1H-NMR and 13C-NMR data are in accordance with the proposed structure

References: [1]Patent: WO2007/39616,2007,A1 .Location in patent: Page/Page column 24-25.

9
[ 1062369-24-7 ]
[ 163295-70-3 ]
[ 1062085-06-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 5268 - 5271.

10
3-methoxy-5-(methylsulfanyl)pyridin-2-amine [ No CAS ]
[ 163295-70-3 ]
C₁₄H₁₄Cl₂N₂O₅S₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; for 1h;	To a solution of 3-methoxy-5-(methylsulfanyl)pyridin-2-amine (191 mg, 0.875 mmol) in pyridine (3 mL) was added <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (227 mg, 0.875 mmol) and the mixture was stirred for 1 hr. The solvent was evaporated and the residue dissolved in DCM (25 mL), then treated with m-chloroperbenzoic acid (70% purity, 367 mg, 1.49 mmol) in three portions. After 15 min, 1M BBr3 in DCM (2.62 mL, 2.62 mmol) was added and the solution stirred for 3 hrs. The reaction was quenched with excess saturated NaHC03 and more DCM was added (15 mL). The phases were separated and the organic phase was washed with brine (3 mL), dried (Na2SC>4), the mixture was filtered and the filtrate evaporated to dryness to afford a brown oil which was purified by automated reverse-phase HPLC (low pH method) (17 mg, 5%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 117.

11
3-amino-5-chloropyridin-4-ol [ No CAS ]
[ 163295-70-3 ]
N-(5-chloro-4-hydroxypyridin-3-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
7%	With pyridine; dmap; at 0℃;	To a stirred solution of 3-amino-5-chloropyridin-4-ol (150 mg, 1.04 mmol) and N,N- dimethylpyridin-4-amine (6 mg, 0.05 mmol) in pyridine (3 mL) at 0C was added (3,5- dichlorophenyl)methanesulfonyl chloride (135 mg, 0.52 mmol) and the mixture stirred overnight. More sulfonyl chloride (67 mg, 0.26 mmol) was added to the reaction mixture and stirring was continued overnight. The mixture was acidified to pH3 with IM HCl and extracted with EtOAc (3xl5mL). The organic layers contained substantial amounts of a pink solid so the mixture was filtered. The solid was washed with HCl (IM) and dried in air to yield the title compound as a pale pink solid (30 mg, 7%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 154.

12
[ 1242336-53-3 ]
[ 163295-70-3 ]
N-(5-chloro-3-hydroxypyridin-2-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

References: [1]Patent: WO2014/184234,2014,A1 .

13
[ 1242336-53-3 ]
[ 163295-70-3 ]
C₁₃H₁₁Cl₃N₂O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; at 20℃; for 64h;	To a solution of 5-chloro-3-methoxypyridin-2-amine (167 mg, 0.821 mmol) in pyridine (3 mL) <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (213 mg, 0.821 mmol) was added and the mixture was stirred at room temperature over 64 hrs. The solvent was evaporated and a rough purification was carried out by silica chromatography (eluent: heptane: EtOAc 2: 1). Product-containing fractions were combined, evaporated, dissolved in DCM (5 mL), then treated with 1M BBr3 in DCM (0.82 mL, 0.82 mmol) and the solution stirred for 3 hrs. The reaction was quenched with excess saturated NaHC03 and more DCM added (15 mL) . The phases were separated and the organic phase was washed with brine (3 mL), dried (Na2SC>4), the mixture was filtered and the filtrate evaporated to dryness to afford a purple grey solid which was purified by slurrying in heptane:EtOAc to afford -(5-chloro-3-hydroxypyridin-2-yl)-l -(3 ,5-dichlorophenyl)methanesulfonamide as a white solid (55 mg, 18%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 106; 107.

14
5-iodo-3-methoxypyridin-2-amine [ No CAS ]
[ 163295-70-3 ]
1-(3,5-dichlorophenyl)-N-(5-iodo-3-methoxypyridin-2-yl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With pyridine; for 16h;	Toa stirred solution of 5-iodo-3-methoxypyridin-2-amine (4.8 g, 0.019 mol ) inpyridine (50 mL) was added <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (5.0 g,0.019 mol) and the reaction mixture stirred for 16 hrs then diluted with waterand extracted with EtOAc (3x 150 mL). The combined organic layers were washed withwater and brine, the organic layer was dried (Na2SC>4), themixture was filtered and the filtrate concentrated to dryness to obtain thecrude product which was purified by silica chromatography (eluent: 20% EtOAc inhexane) to afford the title compound as a yellow solid (5.5 g, 60%);

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 58.

15
[ 163295-70-3 ]
N-(6-chloro-4-hydroxypyridazin-3-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

References: [1]Patent: WO2014/184234,2014,A1 .

16
[ 163295-70-3 ]
N-(5-chloro-3-hydroxypyrazin-2-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

References: [1]Patent: WO2014/184234,2014,A1 .

17
[ 124-41-4 ]
[ 187973-60-0 ]
[ 163295-70-3 ]
1-(3,5-dichlorophenyl)-N-(4-hydroxy-6-iodopyridazin-3-yl)methanesulfonamide [ No CAS ]
N-(6-bromo-4-hydroxypyridazin-3-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16%; 18%		Toa mixture of 6-iodopyridazin-3-amine (500 mg, 2.26 mmol), NaHC03(230 mg, 2.71 mmol) in MeOH (5 mL) was added bromine (117 μ, 2.26 mmol)dropwise. The resulting mixture was stirred at room temperature for 16 hrs. Thesolution was filtered and the filtrate concentrated in vacuo. The residue wasdissolved in water, and the product extracted with EtOAc (3 times). The organiclayers were combined, dried ( a2S04) and concentrated invacuo to give a dark red solid which was purified by flash silicachromatography (eluent: 20% EtOAc :Hexane) to give a 60:40 mixture of the titlecompounds as an off white solid (250 mg); H NMR (400 MHz, CDC13) δ5.49 (s, 4H), 7.66 (s, 1H), 7.81 (s, 1H)Toa stirred solution of a mixture of 4,6-dibromopyridazin-3-amine and 4-bromo-6-iodopyridazin-3-amine (10 g, compounds not separated in previous step,estimated 34 mmol) in methanol (90 mL) was added solid sodium methoxide (3.6 g,67 mmol) at room temperature and the reaction mixture stirred at 90C for16hrs. More sodium methoxide was added regularly until all starting materialhad been consumed. The cooled solution was concentrated in vacuo and theresidue poured into water (200 mL). The resulting solution was extracted withEtOAc three times and the organic layers were combined, dried (MgSC^), andconcentrated in vacuo. The residue was purified by silica column chromatography(eluent: chloroform: methanol (98:0.2 to 90:10) to afford the title mixture ofmethoxy ethers (3.0g, taken into next steps without further purification); HNMR (400 MHz, CDC13) δ 3.90 (s, 3H), 3.92 (s, 3H), 5.05 (m, 3H),6.75 (s, 1H), 6.91 (s, 1H).To a stirred solution of (6-bromo-4-methoxypyridazin-3-amine and 6-iodo-4-methoxy- pyridazin-3 -amine (0.8 g, mixture not separated in previous step, estimated 3.92 mmol) in pyridine (9 mL) was added <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (1.02 g, 3.92 mmol) at room temperature and the mixture stirred for 16 hrs. Water was then added and the mixture extracted with EtOAc (3x 150 mL). The combined organic layers were washed with more water and brine, then concentrated and purified by flash silica chromatography (eluent: 1% MeOH:DCM) to afford a mixture of methoxy ethers (250mg). To this mixture in DCM (5 mL) was added neat boron tribromide (166 μ, 1.76 mmol) and the mixture stirred for 3h before being diluted with DCM and neutralised with saturated NaHC03 (pH 7). The phases were separated and the aqueous phase extracted with DCM and EtOAc. The combined organic layers were dried (MgSC^), the mixture filtered and the filtrate concentrated to dryness to yield an oil which was purified by automated reverse phase HPLC (low pH method) to afford 1 -(3,5-dichlorophenyl)-N-(4- hydroxy-6-iodopyridazin-3-yl)methanesulfonamide (22 mg, 16%) and -(6-bromo-4- hydroxypyridazin-3-yl)-l-(3,5)-dichlorophenyl)methanesulfonamide (22 mg, 18%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 59; 60.

18
[ 808770-39-0 ]
[ 163295-70-3 ]
N-(6-chloro-4-methoxypyridazin-3-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; for 1h;	To a solution of 6-chloro-4-methoxypyridazin-3-amine, prepared using a literature procedure (WO2004108690A1) (403 mg, 1.97 mmol), in pyridine (3 mL) was added <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (51 1 mg, 1.97 mmol) and the mixture was stirred for 1 hr. The solvent was evaporated and the residue dissolved in DCM (100 mL), then treated with 1M BBr3 in DCM (3.9 mL, 3.9 mmol) and the solution stirred 3 hrs. A further 2 mL of the BBr3 solution was added with further stirring for 3 hrs. The reaction was quenched with excess saturated NaHC03 and more DCM was added (15 mL) A significant amount of solid precipitated, so the mixture was filtered and the filtrate reserved. The solid was treated with 3M HC1 until effervescence stopped and was carefully added back to the DCM/ NaHC03 mixture, ensuring the pH did not fall to below 7. The phases were separated and the aqueous phase re-extracted with EtOAc (3x 40 mL). The combined organic phases were dried (Na2SC>4), the mixture was filtered and the filtrate evaporated to dryness to afford brown oil which was purified by reverse-phase HPLC (low pH method). After removal of solvent the residue was slurried with hot EtO Ac/Heptane (1 : 1 , 5 mL) and filtered to afford N-(6-chloro-4-hydroxypyridazin-3-yl)- l-(3,5-dichlorophenyl)methanesulfonamide as a tan solid (90 mg, 12%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 119.

19
[ 808770-39-0 ]
[ 163295-70-3 ]
1-(3,5-dichlorophenyl)-N-[4-methoxy-6-(propylsulfanyl)pyridazin-3-yl]methanesulfonamide [ No CAS ]

References: [1]Patent: WO2014/184234,2014,A1 .

20
[ 5900-13-0 ]
[ 163295-70-3 ]
N-(5-bromo-3-methoxypyrazin-2-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%	With dmap; at 20℃; for 3h;Inert atmosphere;	To a stirring solution of 5-bromo-3-methoxypyrazin-2-amine (1.50 g, 7.35 mmol) in pyridine (15 mL), DMAP (15 mg, 0.12 mmol) and <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (1.91 g, 7.34 mmol) was added. The reaction was left stirring at room temperature under nitrogen for 2 hrs. A further addition of <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (0.20 g, 0.77 mmol) was added to the reaction mixture which was then left stirring for 1 hr at room temperature. The reaction mixture was concentrated in vacuo resulting in a viscous orange mixture which was then diluted with EtOAc (100 mL), washed with water (2 x 80 mL), the organic layer was dried over Na2S04 and concentrated in vacuo to afford an orange solid. This was dissolved in EtOAc (30 mL) and acidified with HCl (2M, 20 mL) which resulted in the precipitation of the title compound as a white solid . The organic and aqueous layer were subsequently separated, the organic layer was washed with water (3 x 30 mL), dried over Na2S04 and concentrated in vacuo to afford a second crop of the title compound as an orange solid (combined yield 1.73g, 54%); H NMR (500 MHz, DMSO) δ 3.93 (s, 3H), 4.88 (s, 2H), 7.36 (d, 2H), 7.63 (m, 1H), 8.12 (s, 1H), 10.80 (s, 1H).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 67; 68.

21
[ 5900-13-0 ]
[ 163295-70-3 ]
N-(5-cyano-3-methoxypyrazin-2-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

References: [1]Patent: WO2014/184234,2014,A1 .

22
[ 52334-90-4 ]
[ 163295-70-3 ]
1-(3,5-dichlorophenyl)-N-(3-hydroxypyridin-4-yl)methanesulfonamide [ No CAS ]

References: [1]Patent: WO2014/184234,2014,A1 .

23
[ 52334-90-4 ]
[ 163295-70-3 ]
C₁₃H₁₂Cl₂N₂O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; at 20℃; for 16h;	To a solution of 4-amino-3-methoxypyridine (93 mg, 0.75 mmol) in pyridine (1 mL) was added <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (195 mg, 0.75 mmol). The mixture was stirred at room temperature for 16h. The intermediate product was collected by filtration, dried in vacuum, suspended in DCM (2 mL), then treated with 1M BBr3 in DCM (0.52 mL, 0.52 mmol) at 0C and the solution stirred at room temperature for 16h. The reaction was quenched with water and ice and the resulting solid precipitate was collected by filtration. The solid was warmed in EtOH (2 mL) and 1M HC1 (1 mL) for 4 hour at 70C. The mixture was diluted with water and the resulting solid precipitate was collected by filtration and dried to afford l-(3,5-dichlorophenyl)-N-(3-hydroxypyridin-4- yl)methanesulfonamide as an off- white solid (10 mg, 4%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 179; 180.

24
[ 874-31-7 ]
[ 163295-70-3 ]
C₁₂H₁₀Cl₃N₃O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; In dichloromethane; at 20℃; for 1h;	To 5-chloro-3-methoxypyrazin-2-amine (150 mg, 0.94 mmol) in pyridine: DCM 1 : 1 (4 mL) at room temperature was added <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (220 mg, 0.846 mmol) was added over 1 min. The mixture was stirred for 1 hr at this temperature then the pyridine was evaporated. The residue was dissolved in DCM (6 mL) and 1M BBr3 in DCM (1.5 mL, 1.5 mmol)) was added and the mixture stirred for 2 hrs. Another 1.5 mL of BBr3 in DCM was added and stirring continued for a further 1 hr. The reaction was quenched carefully with water, EtOAc was added and the phases separated. The EtOAc layer was evaporated and the residue was purified by automated preparative HPLC (low pH method) to afford the title compound as a white solid. Further purification was achieved by recrystallisation from MeOH (51 mg, 15%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 139.

25
[ 101084-20-2 ]
[ 163295-70-3 ]
N-(5-bromo-4-hydroxypyridin-3-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%	With pyridine; dmap; at 80℃; for 1h;	To 3-amino-5-bromopyridin-4-ol (250 mg, 1.32 mmol) in pyridine (3 mL) at 80 C was added a crystal of DMAP then <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> was added in portions over 3 min. The mixture was stirred for 1 hr at this temperature then the pyridine was evaporated. The residue was dissolved in DMSO and precipitated by addition of MeOH. The mixture was filtered and the solid washed with MeOH followed by water and dried in air to afford the title compound as a white solid (82 mg, 15%).

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 148.

26
[ 96833-41-9 ]
[ 163295-70-3 ]
N-(2-chloro-4-methoxypyrimidin-5-yl)-1-(3,5-dichlorophenyl)methanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 22h;	<strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (128 mg, 0.49 mmol) was added to a solution of 2-chloro-4-methoxypyrimidin-5-amine (75 mg, 0.47 mmol) and DIPEA (123 μ, 0.71 mmol) in DCM (2 mL). The reaction was allowed to stir at room temperature for 18 hrs. The reaction was treated with more <strong>[163295-70-3](3,5-dichlorophenyl)methanesulfonyl chloride</strong> (20 mg, 0.08 mmol) and stirred for a further 4 hrs. The reaction was diluted with DCM (15 mL), washed with saturated aqueous citric acid (2 x 6 mL), sat. aq. NaHC03 (2 x 6 mL), brine (6 mL), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated in vacuo. The residue obtained was purified by flash column chromatography over silica (Biotage 10 g SNAP cartridge) eluting with Heptane:EtOAc constant gradient 1 :0 to 7:3 to afford the title compound (108 mg, 60 %) as a white solid; m z=381.8, 383.9 (MH)+.

References: [1]Patent: WO2014/184234,2014,A1 .Location in patent: Page/Page column 72.

27
[ 1445902-93-1 ]
[ 163295-70-3 ]
[ 1445901-64-3 ]

References: [1]ACS Medicinal Chemistry Letters,2015,vol. 6,p. 276 - 281.

28
[ 27507-15-9 ]
[ 163295-70-3 ]
C₁₅H₁₄Cl₂N₂O₄S [ No CAS ]

References: [1]ACS Infectious Diseases,2019,vol. 5,p. 131 - 140.

29
[ 138221-06-4 ]
[ 163295-70-3 ]

References: [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 3088 - 3106.

30
[ 163295-70-3 ]
N-((3,5-dichlorobenzyl)sulfonyl)piperidine-4-carboxamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 3088 - 3106.

31
[ 163295-70-3 ]
1-(3-cyano-5-oxo-5,7-dihydrofuro[3,4-b]pyridin-2-yl)-N-((3,5-dichlorobenzyl)sulfonyl)piperidine-4-carboxamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 3088 - 3106.

32
[ 3290-06-0 ]
[ 163295-70-3 ]

References: [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 3088 - 3106.

Historical Records

Technical Information

• Alkyl Halide Occurrence • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Alkylbenzene • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Vilsmeier-Haack Reaction

Related Functional Groups of
[ 163295-70-3 ]

Aryls

A561586 [24974-73-0]

(3-Chlorophenyl)methanesulfonyl chloride

Similarity: 0.98

A636922 [85952-30-3]

(3,4-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.95

A469293 [6966-45-6]

(4-Chlorophenyl)methanesulfonyl chloride

Similarity: 0.95

A313069 [85952-31-4]

(2,6-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.89

A283400 [163295-71-4]

(2,5-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.89

Sulfonyl Chlorides

A561586 [24974-73-0]

(3-Chlorophenyl)methanesulfonyl chloride

Similarity: 0.98

A636922 [85952-30-3]

(3,4-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.95

A469293 [6966-45-6]

(4-Chlorophenyl)methanesulfonyl chloride

Similarity: 0.95

A313069 [85952-31-4]

(2,6-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.89

A283400 [163295-71-4]

(2,5-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.89

Chlorides

A561586 [24974-73-0]

(3-Chlorophenyl)methanesulfonyl chloride

Similarity: 0.98

A636922 [85952-30-3]

(3,4-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.95

A469293 [6966-45-6]

(4-Chlorophenyl)methanesulfonyl chloride

Similarity: 0.95

A177048 [88691-50-3]

(2,4-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.89

A313069 [85952-31-4]

(2,6-Dichlorophenyl)methanesulfonyl chloride

Similarity: 0.89

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 163295-70-3

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