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CAS No. : | 96833-41-9 | MDL No. : | MFCD12402341 |
Formula : | C5H6ClN3O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | BTTZBKYSXZSBAS-UHFFFAOYSA-N |
M.W : | 159.57 | Pubchem ID : | 21186356 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.2 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 37.94 |
TPSA : | 61.03 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.71 cm/s |
Log Po/w (iLOGP) : | 1.66 |
Log Po/w (XLOGP3) : | 0.79 |
Log Po/w (WLOGP) : | 0.73 |
Log Po/w (MLOGP) : | -0.25 |
Log Po/w (SILICOS-IT) : | 0.86 |
Consensus Log Po/w : | 0.76 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.71 |
Solubility : | 3.15 mg/ml ; 0.0197 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.65 |
Solubility : | 3.55 mg/ml ; 0.0223 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.02 |
Solubility : | 1.51 mg/ml ; 0.00944 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.01 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | at 20℃; for 1.5 h; | Preparation 164 2-Chloro-4-methoxypyrimidin-5-amine Sodium methoxide (0.5M in methanol, 3.7 mL, 1.829 mmol) was added to a solution of 2,4-dichloropyrimidin-5-amine (0.2 g, 1.220 mmol) in MeOH (2.5 mL). The reaction was stirred at room temperature for 1.5 hours. The reaction was then diluted with EtOAc and quenched with water. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried (Na2SO4), filtered and concentrated under reduced pressure to afford the title product as a brown solid (177 mg, 91percent). 1H NMR (500 MHz, CDCl3): δ 3.93 (s, 3H), 5.31 (br s, 2H), 7.73 (s, 1H). LC (Method B)-MS (ESI, m/z) tR 1.6 min, 160 [M+H]+ |
83% | at 0 - 20℃; for 66 h; Inert atmosphere | 5.4Msodium methoxide (100 μ, 0.54 mmol) was added dropwise to a stirring solutionof 2,4-dichloropyrimidin-5 -amine (89 mg, 0.54 mmol) in methanol (2 mL) at 0 °Cunder nitrogen. The reaction was allowed to warm to room temperature andstirred for 1 hr. The reaction was treated with more 5.4M sodium methoxide (10μ) and stirred for a further 1 hr, then left to stand at room temperature for64 hrs. The reaction was quenched with acetic acid (1 mL) and concentrated invacuo. The residue was dissolved in EtOAc (20 mL) and washed with saturatedaqueous NaHC03 (2 x 6 mL), brine (6 mL), dried over Na2SC>4,filtered and the filtrate was concentrated in vacuo. The residue obtained waspurified by flash column chromatography over silica (Biotage 10 g SNAPcartridge) eluting with heptane:EtOAc , smooth gradient 1 :0 to 7:3 to affordthe title compound as a white solid (80 mg, 83percent) ; H NMR (500 MHz,DMSO) δ 3.93 (s, 3H), 5.31 (s, 2H), 7.72 (s, 1H). |
0.35 g | for 16 h; Reflux | A mixture of 2,4-dichloropyrimidin-5-amine (0.5 g, 3.04 mmol), sodium methoxide (0.66 g, 12.19 mmol) and methanol (10 ml) was refluxed for 16 hours. The solvent was removed under reduced pressure. Water was added and the aqueous phase was extracted with ethyl acetate. The organic phase was washed with water and brine, dried over sodium sulphate and concentrated under reduced pressure. The yield of 2-chloro-4-methoxypyrimidin-5-amine after flash chromatography (100-200 mesh size silica gel, 20-25percent ethyl acetate in hexane) was 0.35 g. N-Bromosuccinimide (67 mg, 0.37 mmol) was added to a solution of 2-chloro-4-methoxypyrimidin-5-amine (50 mg, 0.31 mmol) in chloroform (2 ml) and the resulting mixture was stirred at RT for 3 hours. Water was added and the mixture extracted with chloroform. The organic phase was washed with water and brine, dried over sodium sulphate and concentrated under reduced pressure. The yield of 4-bromo-2-chloro-6-methoxypyrimidin-5-amine was 60 mg. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | at 20℃; for 1.5 h; | Preparation 164: 2-Chloro-4-methoxypyrimidin-5-amine; [00336] Sodium methoxide (0.5M in methanol, 3.7ml_, 1 .829mmol) was added to a solution of 2,4-dichloropyrimidin-5-amine (0.2g, 1 .220mmol) in MeOH (2.5ml_). The reaction was stirred at room temperature for 1 .5 hours. The reaction was then diluted with EtOAc and quenched with water. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried (Na2S04), filtered and concentrated under reduced pressure to afford the title product as a brown solid (177mg, 91 percent).1 H NMR (500MHz, CDCI3): δ 3.93 (s, 3H), 5.31 (br s, 2H), 7.73 (s, 1 H). LC (Method B)-MS (ESI, m/z) fR 1 .6 min, 160 [M+H]+ |
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