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Chemical Structure| 16358-79-5 Chemical Structure| 16358-79-5

Structure of 16358-79-5

Chemical Structure| 16358-79-5

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Product Details of [ 16358-79-5 ]

CAS No. :16358-79-5
Formula : C11H14O
M.W : 162.23
SMILES Code : O=CC1=CC=CC=C1C(C)(C)C
MDL No. :MFCD15527514
InChI Key :TWQRQNJOSFBCJV-UHFFFAOYSA-N
Pubchem ID :13184777

Safety of [ 16358-79-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360-H302-H317-H410
Precautionary Statements:P201-P202-P261-P264-P270-P272-P273-P280-P301+P310+P330-P302+P352-P308+P313-P333+P313-P391-P405-P501
Class:9
UN#:3082
Packing Group:

Application In Synthesis of [ 16358-79-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16358-79-5 ]

[ 16358-79-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 62171-59-9 ]
  • [ 33513-42-7 ]
  • [ 16358-79-5 ]
YieldReaction ConditionsOperation in experiment
86% 11.8g (45.4 mmol) of Intermediate 47-1 were dissolved in 60ml of tetrahydrofuran. The orange solution was bubbled with argon and cooled to -78C.18.48ml (49.9mmol) of n- butyllithium (2.7M in pentane) were added slowly and the reaction mixture was stirred for 30 minutes.3.86ml (49.9mmol) of N,N-dimethylformamide were added at -78C and stirred for 30 minutes at this temperature, then it was heated up to room temperature and stirred for 18 hours.100ml of water and 100ml of heptane were added, the phases were separated and the water phase was extracted with heptane. The combined organic phases were washed with water and brine, dried over magnesium sulfate, filtered and concentrated under vacuum to give 9.24g (86% yield) of Intermediate 47-2. 1H NMR (300 MHz, Methylene Chloride-d2) d 10.83 (d, J = 0.9 Hz, 1H), 7.89 (dt, J = 7.6, 1.1 Hz, 1H), 7.58- 7.44 (m, 2H), 7.40- 7.23 (m, 1H), 1.52 (s, 9H).
  • 2
  • [ 1077-58-3 ]
  • [ 16358-79-5 ]
 

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