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Chemical Structure| 164179-52-6 Chemical Structure| 164179-52-6

Structure of 164179-52-6

Chemical Structure| 164179-52-6

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Product Details of [ 164179-52-6 ]

CAS No. :164179-52-6
Formula : C8H8FI
M.W : 250.05
SMILES Code : ICCC1=CC=C(F)C=C1
MDL No. :MFCD18207442

Safety of [ 164179-52-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H312-H315-H318-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 164179-52-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 164179-52-6 ]

[ 164179-52-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57611-47-9 ]
  • [ 164179-52-6 ]
  • methyl 1-benzyl-3-(4-fluorophenethyl)-4-oxopiperidine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With potassium carbonate; In acetone; for 21h;Reflux; General procedure: In a round bottom flask containing a magnetic stir bar was added 1-fluoro-4-(2-iodoethyl)benzene (2.00g, 7.99mmol), <strong>[57611-47-9]methyl 1-benzyl-4-oxopiperidine-3-carboxylate</strong> HCl salt (1.86g, 6.57mmol), and potassium carbonate (3.63g, 26.3mmol) which were dissolved in acetone (40mL) and refluxed for 21h. After cooling to room temperature the crude material was filtered and condensed in vacuo onto silica gel for purification using Teledyne ISCO Combi Flash system (80g column, solid loading on silica, 0-15% EtOAc in hexanes, 30min run) to afford methyl 1-benzyl-3-(4-fluorophenethyl)-4-oxopiperidine-3-carboxylate (1.3g, 54%) as a yellow tinted, viscous oil.
 

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