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Chemical Structure| 16499-66-4 Chemical Structure| 16499-66-4

Structure of 16499-66-4

Chemical Structure| 16499-66-4

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Product Details of [ 16499-66-4 ]

CAS No. :16499-66-4
Formula : C9H4ClF3N2
M.W : 232.59
SMILES Code : FC(C1=CC=CC2=C(Cl)N=CN=C12)(F)F
MDL No. :MFCD09837195

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Application In Synthesis of [ 16499-66-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16499-66-4 ]

[ 16499-66-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 89694-46-2 ]
  • [ 16499-66-4 ]
  • [ 1112985-56-4 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; at 80℃; for 6h;Inert atmosphere; Example 47 4-(2-chloro-5-methoxyphenyl)-8-(trifluoromethyl)quinazoline A stream of nitrogen gas was bubbled through a mixture of 4-chloro-8-(trifluoromethyl)quinazoline (660 mg, 2.83 mmol), <strong>[89694-46-2]2-chloro-5-methoxyphenylboronic acid</strong> (723 mg, 4.26 mmol), 2M aqueous Na2CO3 (4.25 mL, 8.5 mmol) in dimethoxyethane (8 mL) for 10 min. Tetrakis-triphenylphosphine palladium (168 mg, 0.14 mmol) was added and the mixture was stirred at 80° C. for 6 h. The suspension was cooled and poured into a mixture of EtOAc (60 mL) and water (30 mL). The layers were separated and the organic layer was further washed with aqueous NaHCO3 (10 mL), water (10 mL), and brine (20 mL). The organic layer was dried with Na2SO4 and concentrated in vacuo. The residue was purified by silica gel chromatography eluding with a gradient of 0:100 to 20:80 E:H to afford white foamy solid (640 mg). MS (ES) m/z 338.7; HRMS: calcd for C16H10ClF3N2O+H+, 339.05065; found (ESI, [M+H]+ Obs'd), 339.0510.
 

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