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Chemical Structure| 16524-04-2 Chemical Structure| 16524-04-2

Structure of 16524-04-2

Chemical Structure| 16524-04-2

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Product Details of [ 16524-04-2 ]

CAS No. :16524-04-2
Formula : C7H6Br2N2O
M.W : 293.94
SMILES Code : O=C(N)C1=CC(Br)=CC(Br)=C1N
MDL No. :MFCD01219552

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Application In Synthesis of [ 16524-04-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16524-04-2 ]

[ 16524-04-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 606-00-8 ]
  • [ 16524-04-2 ]
YieldReaction ConditionsOperation in experiment
With ammonium hydroxide; at 100℃; for 12h;Sealed tube; General procedure: The syntheses of compounds 3a-3x were mainly referred to literature method [35]. A mixture of 1a-1q, 1w, 1x (2mmol), EDC?HCl (575mg, 3mmol), HOBt (446mg, 3.3mmol), NH4Cl (348mg, 6.5mmol) and DIPEA (2.3mL, 13mmol) in DMSO (7mL) was stirred at room temperature for 15h. The mixture was extracted with EtOAc three times, and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford 3a-3q, 3w, 3x. A mixture of 2r-2v (2mmol) and NH3·H2O (25-28wt%, 80mmol) in sealed tube was heated at 100C for 12h. The mixture was cooled to room temperature and extracted with EtOAc three times. The combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford 3r-3v.
 

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