[ CAS No. 167102-62-7 ] {[proInfo.proName]}

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COA NMR CNMR HPLC LC-MS

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Product Details of [ 167102-62-7 ]

CAS No. :	167102-62-7	MDL No. :	MFCD09878778
Formula :	C₁₃H₂₄N₂O₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	288.34	Pubchem ID :	-
Synonyms :

Safety of [ 167102-62-7 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 167102-62-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 167102-62-7 ]

[ 167102-62-7 ] Synthesis Path-Downstream 1~5

1
[ 77-76-9 ]
[ 167102-61-6 ]
[ 167102-62-7 ]

Yield	Reaction Conditions	Operation in experiment
98%	With pyridinium p-toluenesulfonate; In benzene; at 75 - 85℃; for 5.0h;Dean-Stark;	A suspension of (R)-i
170 g	With boron trifluoride diethyl etherate; In acetone; at 25 - 30℃; for 0.05h;	(R)-Tert-b ty (3-hydroxy- 1 -(methoxy(methyl)amino)- 1 -oxopropan-2-yl)carbamate (150 gms) and acetone (1995 ml) were charged into a round bottom flask. 2,2- Dimethoxypropane (530 gms / 627 ml) was added to the mixture and stirred for 15 min. Bo- ron trifluoride etherate (5.65 gms) was added to the reaction mixture at 25-30C and stirred for 3 hrs. Triethylamine (2.01 ml) was added to the above reaction mixture and stirred for 15 min. Distilled off the solvent completely from reaction mixture under reduced pressure to get the title compound. (Yield: 170.0 gms).

Reference： [1]Journal of the American Chemical Society,2013,vol. 135,p. 12964 - 12967
[2]Patent: WO2017/180794,2017,A1 .Location in patent: Page/Page column 63; 64
[3]Tetrahedron,1995,vol. 51,p. 8121 - 8134
[4]Synthesis,1998,p. 1707 - 1709
[5]Journal of the American Chemical Society,2008,vol. 130,p. 2351 - 2364
[6]Tetrahedron Asymmetry,2013,vol. 24,p. 1233 - 1239
[7]Patent: WO2019/82209,2019,A1 .Location in patent: Page/Page column 27; 28

2
[ 167102-62-7 ]
[ 95715-87-0 ]

Yield	Reaction Conditions	Operation in experiment
100%	With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.5h;
100%	With lithium aluminium tetrahydride In 2-methyltetrahydrofuran at 0℃;
92%	With lithium aluminium tetrahydride In tetrahydrofuran for 2.33333h; Inert atmosphere; Cooling;

100 g

With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 0 - 30℃; for 3h;

13 Example-13: Preparation of (R)-tert-butyl 4-formyl-2,2-dimethyloxazolidine-3- carboxylate. Tert-b ty 4-(methoxy(methyl)carbamoyl)-2,2-dimethyloxazolidine-3-carboxylate (170 gms) was added to toluene (870 ml) at 25-30°C and stirred for 15 min. Cooled the reaction mixture to 0-5°C. Sodium bis(2-methoxyethoxy)aluminum hydride (348.7 ml) was slowly added to the reaction mixture at 0-5°C and stirred for 3 hrs at the same temperature. The obtained reaction mixture was slowly added to a pre-cooled aqueous sodium potassium tartrate solution (100 gms in 1044 ml of water). Heated the reaction mixture to 25-30°C and stirred for 45 min. Filtered the reaction mixture through hyflow bed and washed the bed with toluene. Separated the both organic and aqueous layers. Distilled off the solvent completely from the organic layer under reduced pressure to get the title compound. (Yield: 100.0 gms).

Reference： [1]Campbell, Andrew D.; Raynham, Tony M.; Taylor, Richard J. K. [Synthesis, 1998, # 12, p. 1707 - 1709]
[2]Bungard, Christopher J.; Williams, Peter D.; Schulz, Jurgen; Wiscount, Catherine M.; Holloway, M. Katharine; Loughran, H. Marie; Manikowski, Jesse J.; Su, Hua-Poo; Bennett, David J.; Chang, Lehua; Chu, Xin-Jie; Crespo, Alejandro; Dwyer, Michael P.; Keertikar, Kartik; Morriello, Gregori J.; Stamford, Andrew W.; Waddell, Sherman T.; Zhong, Bin; Hu, Bin; Ji, Tao; Diamond, Tracy L.; Bahnck-Teets, Carolyn; Carroll, Steven S.; Fay, John F.; Min, Xu; Morris, William; Ballard, Jeanine E.; Miller, Michael D.; McCauley, John A. [ACS Medicinal Chemistry Letters, 2017, vol. 8, # 12, p. 1292 - 1297]
[3]Cortes-Clerget, Margery; Gager, Olivier; Monteil, Maelle; Pirat, Jean-Luc; Migianu-Griffoni, Evelyne; Deschamp, Julia; Lecouvey, Marc [Advanced Synthesis and Catalysis, 2016, vol. 358, # 1, p. 34 - 40]
[4]Current Patent Assignee: MSN LABORATORIES PRIVATE LIMITED - WO2019/82209, 2019, A1 Location in patent: Page/Page column 28

3
[ 19578-68-8 ]
[ 167102-62-7 ]
[ 488835-95-6 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 4-(4-benzyloxyphenyl) iodide With magnesium In diethyl ether at 25℃; Stage #2: (R)-N,O-isopropylidenyl-2-(N-tert-butyloxycarbonylamino)-3-oxo-propanamide-N,O-dimethyl-hydroxyamine In diethyl ether
	With magnesium In diethyl ether at 25℃;	8.11.a The synthesis of ketone derivatives:39a-b is outlmed m acnemc 11. Serine was converted in three steps into Weinreb's hydroxamate 36; whose condensation with the Grignard reagent 4-benzyloxyphenyl magnesium iodide proceeded to give the expected ketone 37 in modest yield. TFA deprotection afforded the ammonium salt 38, which underwent selective acylation followed by phosphorylation. TFA deprotection provided ketones 39a-b.

Reference： [1]Heasley, Brian H.; Jarosz, Renata; Lynch, Kevin R.; Macdonald, Timothy L. [Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 11, p. 2735 - 2740]
[2]Current Patent Assignee: UNIVERSITY OF VIRGINIA - WO2005/115150, 2005, A2 Location in patent: Page/Page column 95-96

4
[ 660852-86-8 ]
[ 6638-79-5 ]
[ 167102-62-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 3996 - 4003

5
[ 77-76-9 ]
[ 67-64-1 ]
[ 167102-61-6 ]
[ 167102-62-7 ]

Reference： [1]Advanced Synthesis and Catalysis,2016,vol. 358,p. 34 - 40

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P101	If medical advice is needed,have product container or label at hand.
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P321
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P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
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P378
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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H240	Heating may cause an explosion
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H242	Heating may cause a fire
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H310	Fatal in contact with skin
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H401	Toxic to aquatic life
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H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 167102-62-7 ] {[proInfo.proName]}

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[ 167102-62-7 ] Synthesis Path-Downstream 1~5

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