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Chemical Structure| 16722-38-6 Chemical Structure| 16722-38-6

Structure of 16722-38-6

Chemical Structure| 16722-38-6

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Product Details of [ 16722-38-6 ]

CAS No. :16722-38-6
Formula : C10H4Cl2O4
M.W : 259.04
SMILES Code : O=C(C1=CC(C2=C(O1)C(Cl)=CC(Cl)=C2)=O)O
MDL No. :MFCD01416671

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Application In Synthesis of [ 16722-38-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16722-38-6 ]

[ 16722-38-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3321-92-4 ]
  • [ 95-92-1 ]
  • [ 16722-38-6 ]
YieldReaction ConditionsOperation in experiment
50% To a solution of sodium ethoxide (16.6 g, 244 mmol) in EtOH (60 mL) was added 1-(3,5- dichloro-2-hydroxyphenyl)ethanone (10 g, 48.8 mmol) and diethyl oxalate (42.8 g, 40 mL, 293 mmol) was added and then the resulting mixture was stuffed at 80 C for 12 hours. After the reaction was completed, the mixture was adjusted to pH-4 by addition of 4N HC1 and thenextracted with EtOAc (50 mL) three times. The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue (15 g, 48.8 mmol) was dissolved in the mixed solvent of AcOH (100 mL) and HC1 (20 mL) and the resulting mixture was then stuffed at 80 C for 5 hours. After the reaction was completed, the mixture was adjusted to pH-3 by addition of 4N HC1 and then extracted with EtOAc (150 mL) three times. Thecombined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give 6,8-dichloro-4-oxo-chromene-2-carboxylic acid (6.3 g, 50 %) as a yellow solid which was used in next step directly without further purification. MS obsd. (ESI) [(M+H)]:259.1&261.1
 

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