Home Cart 0 Sign in  

[ CAS No. 167303-60-8 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 167303-60-8
Chemical Structure| 167303-60-8
Structure of 167303-60-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 167303-60-8 ]

Related Doc. of [ 167303-60-8 ]

SDS
Alternatived Products of [ 167303-60-8 ]
Alternatived Products of [ 167303-60-8 ]

Product Details of [ 167303-60-8 ]

CAS No. :167303-60-8MDL No. :MFCD22421521
Formula : C12H16N2O3 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :236.27Pubchem ID :-
Synonyms :

Computed Properties of [ 167303-60-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 167303-60-8 ]

Signal Word:WarningClass:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338UN#:
Hazard Statements:H302-H315-H319-H335Packing Group:
GHS Pictogram:

Application In Synthesis of [ 167303-60-8 ]

  • Upstream synthesis route of [ 167303-60-8 ]
  • Downstream synthetic route of [ 167303-60-8 ]

[ 167303-60-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 167303-60-8 ]
  • [ 1857-19-8 ]
YieldReaction ConditionsOperation in experiment
94% With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 3 h; General procedure: This procedure is illustrated for compound 11a. To a solution of compound 10a (170 mg, 0.77 mmol) in methanol (10 mL), 10percent Pd/C was added. The reaction was hydrogenated at room temperature and atmospheric pressure for 3 h. Then the catalyst was filtered off through Celite, and the clear solution, taken to dryness, afforded the title compound as an oil. The reaction was monitored by TLC and, for stability problems, the amine was directly used in the subsequent reaction. Yield 97percent.
Reference: [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 3, p. 1285 - 1297
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 16, p. 2715 - 2718
[3] Chemical Communications, 2016, vol. 52, # 43, p. 7043 - 7046
Historical Records