Alternatived Products of [ 168169-11-7 ]
Alternatived Products of [ 168169-11-7 ]
Product Details of [ 168169-11-7 ]
CAS No. : | 168169-11-7 | MDL No. : | MFCD08704822 |
Formula : |
C15H16BrNO2
|
Boiling Point : |
375.867°C at 760 mmHg |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 322.20 | Pubchem ID : | - |
Synonyms : |
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Computed Properties of [ 168169-11-7 ]
TPSA :Topological Polar Surface Area |
- |
H-Bond Acceptor Count : |
- |
XLogP3 : |
- |
H-Bond Donor Count : |
- |
SP3 : |
- |
Rotatable Bond Count : |
- |
Safety of [ 168169-11-7 ]
Signal Word: | | Class: | |
Precautionary Statements: | | UN#: | |
Hazard Statements: | | Packing Group: | |
Application In Synthesis of [ 168169-11-7 ]
- Downstream synthetic route of [ 168169-11-7 ]
- 1
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[ 24424-99-5 ]

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[ 2298-07-9 ]

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[ 168169-11-7 ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium hydroxide; In tetrahydrofuran; water; at 20℃; for 96h; |
4-Bromo-l-naphthylamine (5.0g, 22.5 mmol) and ditertbutyldicarbonate (7.4 g, 33.9 mmol) in tetrahydrofuran (75 ml) and 1Msodium hydroxide (75 ml) are stirred at room temperature for 4 days. The mixture is thenpoured into ethyl acetate (250 ml) and washed with water (300 ml). The ethyl acetate layer isdried over anhydrous sodium sulfate and evaporated to dryness. The residue is purified bycolumn chromatography on silica gel eluted with 10% ethyl acetate in hexanes thenrecrystalized from ethyl acetate and hexanes to yield (4-bromo-naphthalen-l-yl)-carbamic acidtert-butyl ester (3.669 g). |
Reference:
[1]Journal of Medicinal Chemistry,2019,vol. 62,p. 7089 - 7110
[2]Chemistry - A European Journal,2016,vol. 22,p. 1484 - 1492
[3]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 2599 - 2606
[4]Patent: WO2006/10082,2006,A1 .Location in patent: Page/Page column 132-133