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Chemical Structure| 170701-87-8 Chemical Structure| 170701-87-8

Structure of 170701-87-8

Chemical Structure| 170701-87-8

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Product Details of [ 170701-87-8 ]

CAS No. :170701-87-8
Formula : C12H13NO4
M.W : 235.24
SMILES Code : COC(=O)C1CN1C(=O)OCC1=CC=CC=C1
MDL No. :MFCD02093687

Safety of [ 170701-87-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 170701-87-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 170701-87-8 ]

[ 170701-87-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 170701-87-8 ]
  • [ 134441-61-5 ]
  • tert-butyl (R)-2-(((S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropoxy)methyl)piperidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With boron trifluoride diethyl etherate; In chloroform; at 0 - 20℃; Synthesis of tert-butyl (R)-2-(((S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3- oxopropoxy)methyl)piperidine-l-carboxylate: to a stirred solution of 1 -benzyl 2-methyl (S)-aziridine-l,2- dicarboxylate (2.0 g, 8.50 mmol) and tert-butyl (R)-2-(hydroxymethyl)piperidine-l-carboxylate (7.32 g, 34.01 mmol) in chloroform (50 mL) at 0 C was added boron trifluoride etherate (603.34 mg, 4.25 mmol). The resulting solution was stirred overnight at rt. The resulting solution was diluted with DCM (100 mL), washed with H2O (3 x 50 mL). The organic layer was dried over Na2S04 and concentrated in vacuo to afford crude tert-butyl (R)-2-(((S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3- oxopropoxy)methyl)piperidine-l-carboxylate as an oil (8 g), which was used for next step reaction without further purification.
 

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