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Chemical Structure| 171178-51-1 Chemical Structure| 171178-51-1

Structure of 171178-51-1

Chemical Structure| 171178-51-1

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Product Details of [ 171178-51-1 ]

CAS No. :171178-51-1
Formula : C6H4F2N2O
M.W : 158.11
SMILES Code : O=C(N)C1=C(F)N=C(F)C=C1

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Application In Synthesis of [ 171178-51-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 171178-51-1 ]

[ 171178-51-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 171178-50-0 ]
  • [ 171178-51-1 ]
YieldReaction ConditionsOperation in experiment
3.05 g With thionyl chloride; In 1,2-dichloro-ethane; at 70℃; for 3h; To a dichloroethane solution (28.0 mL) of <strong>[171178-50-0]2,6-difluoropyridine-3-carboxylic acid</strong> (3.41 g) was added thionyl chloride (9.16 mL) at room temperature, and the reaction mixture was stirred at 70C for 3 h After cooling to room temperature, the solvent was evaporated under reduced pressure. To a diethyl ether solution (46.0 mL) of the residue was added 28% aqueous ammonia (4.60 mL) at 0C and the mixture was stirred for 10 min. Saturated aqueous sodium hydrogen carbonate solution was added and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to give the title compound (3.05 g). MS(ESI)m/z; 159[M+H]+
 

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