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Chemical Structure| 17258-21-8 Chemical Structure| 17258-21-8

Structure of 17258-21-8

Chemical Structure| 17258-21-8

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Product Details of [ 17258-21-8 ]

CAS No. :17258-21-8
Formula : C6H9N3
M.W : 123.16
SMILES Code : NC1=NN=C(C)C=C1C
MDL No. :MFCD01692870

Safety of [ 17258-21-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 17258-21-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17258-21-8 ]

[ 17258-21-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33142-21-1 ]
  • [ 17258-21-8 ]
  • ethyl 6,8-dimethylimidazo[1,2-b]pyridazine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
14% With N-ethyl-N,N-diisopropylamine; In ethanol; at 75℃; for 16h; To a suspension of 4,6-dimethylpyridazin-3-amine (1.23 g, 10.0 mmol) in 10 mL ofEtOH was added DIPEA (12.9 g, 100 mmol) and <strong>[33142-21-1]ethyl 2-chloro-3-oxopropanoate</strong> (3.00 g, 20.0mmol). The reaction mixture was stirred at 75 C for 16 h, cooled to RT, and concentrated in vacuo. The resulting residue was partitioned between EtOAc and water, and the organic layer was separated, washed with brine (20 mL), dried over Mg504, filtered, and concentrated in vacuo. The resulting residual brown solid was purified on a silica gel flash chromatography column (EAIPE; 1:1) to give ethyl 6,8-dimethylimidazo[1,2-bjpyridazine-3-carboxylate (300 mg, 14%) as a yellow solid. ?H NMR (500 MHz, CDC13): oe 8.27 (s, 1H), 9.40 (s, 1H), 4.47 (q, J 9.0 Hz, 2H), 2.66 (s, 6H), 1.45 (t, J 9.0 Hz, 3H). LC-MS m/z: 220.1 [M+Hj
 

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