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Chemical Structure| 172749-96-1 Chemical Structure| 172749-96-1

Structure of 172749-96-1

Chemical Structure| 172749-96-1

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Product Details of [ 172749-96-1 ]

CAS No. :172749-96-1
Formula : C9H17NO4S
M.W : 235.30
SMILES Code : O=C(OC)C(NC(OC(C)(C)C)=O)CS
MDL No. :MFCD24390201

Safety of [ 172749-96-1 ]

Application In Synthesis of [ 172749-96-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 172749-96-1 ]

[ 172749-96-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 2815-95-4 ]
  • [ 172749-96-1 ]
  • [ 1314941-71-3 ]
YieldReaction ConditionsOperation in experiment
79% To a solution of carboxylic acid 15a-b, 14a-b or 16a-b (1 mmol) in CH2Cl2 (10 mL) was added methyl N-(tert-butoxycarbonyl)-L-cysteine (10) (282 mg, 1.2 mmol). The mixture was stirred at 0 C for 15 min, then triethylamine (0.5 mL, 4 mmol) followed by bis(2-oxo-3-oxazolidinyl)phosphonic chloride (BOPCl) (381 mg, 1.5 mmol) were added. The solution was kept at room temperature for 3 h. After the removal of the solvent under the reduced pressure, the residue was added EtOAc (30 mL) and washed with water (3 * 2 mL), brine (10 mL) and dried over anhydrous Na2SO4. After the solvent was removed under the reduced pressure, the residue was purified by silica-gel column chromatography to give the corresponding thioester conjugates 5a-b, 6a-b or 18a-b.
  • 2
  • [ 5926-51-2 ]
  • C10H11N5 [ No CAS ]
  • [ 172749-96-1 ]
  • (R)-methyl 3-((2-(4-azidobenzyl)-3,6-dioxo-1-(prop-2-yn-1-yl)-1,2,3,6-tetrahydropyridazin-4-yl)thio)-2-((tert-butoxycarbonyl)amino)propanoate [ No CAS ]
  • (R)-methyl 3-((1-(4-azidobenzyl)-3,6-dioxo-2-(prop-2-yn-1-yl)-1,2,3,6-tetrahydropyridazin-4-yl)thio)-2-((tert-butoxycarbonyl)amino)propanoate [ No CAS ]
  • 3
  • [ 5926-51-2 ]
  • C10H11N5 [ No CAS ]
  • [ 172749-96-1 ]
  • (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-((3,6-dioxo-1-(prop-2-yn-1-yl)-1,2,3,6-tetrahydropyridazin-4-yl)thio)propanoate [ No CAS ]
  • C16H21N3O6S [ No CAS ]
 

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