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Chemical Structure| 172975-98-3 Chemical Structure| 172975-98-3

Structure of 172975-98-3

Chemical Structure| 172975-98-3

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Product Details of [ 172975-98-3 ]

CAS No. :172975-98-3
Formula : C13H13N
M.W : 183.25
SMILES Code : NC1C=CC=C(C2C=CC=CC=2)C=1C
MDL No. :MFCD14585563

Safety of [ 172975-98-3 ]

Application In Synthesis of [ 172975-98-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 172975-98-3 ]

[ 172975-98-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 573675-31-7 ]
  • [ 172975-98-3 ]
  • 7-bromo-N-(2-methylbiphenyl-3-yl)pyrido[3,2-d]pyrimidin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Step 1: 7-bromo-N-(2-methylbiphenyl-3-yl)pyrido[3,2-d]pyrimidin-4-amine To a vial was added 2-methylbiphenyl-3-amine (Example 1, Step 1: 0.4 g, 2.18 mmol), <strong>[573675-31-7]7-bromo-4-chloropyrido[3,2-d]pyrimidine</strong> (Ark Pharm, cat#AK-27560: 540 mg, 2.2 mmol), and isopropyl alcohol (10. mL) The mixture was heated to 110 C. for 4 h. The mixture was cooled to room temperature, concentrated, and the crude product was used directly in the next step without further purification. LC-MS calculated for C20H16BrN4 (M+1)+: m/z=391.1; found 391.1.
  • 2
  • [ 907597-26-6 ]
  • [ 172975-98-3 ]
  • [ 76-05-1 ]
  • N-(2-methylbiphenyl-3-yl)isothiazolo[4,5-b]pyrazin-3-amine trifluoroacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
A mixture of <strong>[907597-26-6]3-bromoisothiazolo[4,5-b]pyrazine</strong> (Ark Pharm, catAK-30773: 17 mg, 0.080 mmol), 2-methylbiphenyl-3-amine (Example 11, Step 1: 14.7 mg, 0.080 mmol), [(2-di-cyclohexylphosphino-3,6-dimethoxy-2?,4?,6?-triisopropyl-1,1?-biphenyl)-2-(2?-amino-1,1?-biphenyl)]palladium(II) methanesulfonate (BrettPhos Pd G3, 11 mg, 0.012 mmol), and cesium carbonate (130 mg, 0.40 mmol) in tert-butyl alcohol was purged with nitrogen, and then stirred at 100 C. for 2 h. After being cooled to room temperature, the crude reaction mixture was diluted with methanol and purified by prep HPLC (pH=2, acetonitrile/water+TFA) to provide the desired compound as the TFA salt. LC-MS calculated for C18H15N4S (M+H)+: m/z=319.1; found 319.2.
 

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