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Chemical Structure| 173470-67-2 Chemical Structure| 173470-67-2

Structure of 173470-67-2

Chemical Structure| 173470-67-2

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Product Details of [ 173470-67-2 ]

CAS No. :173470-67-2
Formula : C9H8O2
M.W : 148.16
SMILES Code : OCC1=C2C=COC2=CC=C1
MDL No. :MFCD10699417

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Application In Synthesis of [ 173470-67-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 173470-67-2 ]

[ 173470-67-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 166599-84-4 ]
  • [ 173470-67-2 ]
YieldReaction ConditionsOperation in experiment
With borane-THF; In tetrahydrofuran; at 20℃; for 1h; To <strong>[166599-84-4]benzofuran-4-carboxylic acid</strong> (50 mg, 0.308 mmol, commercially available from, for example, J&W PharmLab) in THF (1 mL), borane tetrahydrofuran complex (0.47 mL, 1M in THF, 0.470 mmol) was added and the reaction stirred at rt for 1 h. The reaction was quenched with NaHCO3 (20 mL)and extracted with EtOAc (3 x 10 mL). The organic layers were dried over a hydrophobic frit and concentrated to give 50 mg of a colourless oil. This was purified bychromatography on 5i02 (Biotage SNAP 10 g cartridge, eluting with O-5O% EtOAc/cyclohexane), theappropriate fractions were concentrated to give benzofuran-4-ylmethanol (37 mg, 0.225 mmol, 72.9 % yield) as a white solid.LCMS (2 mm Formic): Rt = 0.72 mi [M-OH] = 131.1.
 

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