Alternatived Products of [ 173841-06-0 ]
Product Details of [ 173841-06-0 ]
| CAS No. : | 173841-06-0 |
MDL No. : | MFCD22573939 |
| Formula : |
C6H7ClN2O2
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
174.59
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 173841-06-0 ]
Application In Synthesis of [ 173841-06-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 173841-06-0 ]
- 1
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[ 52867-42-2 ]
-
[ 173841-06-0 ]
| Yield | Reaction Conditions | Operation in experiment |
| 2 g |
With trichlorophosphate; In N,N-dimethyl-formamide; at 100℃; for 5h; |
The substrate 22 (5 g) was dissolved in DMF (10 mL), phosphorus oxychloride (10 mL) was added to the reaction system at room temperature, the temperature was raised to 100 C, and the reaction was carried out for 5 h, and the reaction system was poured into ice water, ethyl acetate (3*) The mixture was extracted with EtOAc (3 mL). MS (M+1 = 219). |
| 2 g |
With trichlorophosphate; In N,N-dimethyl-formamide; at 20 - 100℃; for 5h; |
Substrate 2 (5g) was dissolved in DMF (10mL), phosphorus oxychloride (10mL) was added to the reaction system at room temperature, the temperature was raised to 100 degrees, the reaction was carried out for 5h, and the reaction system was poured into ice water, ethyl acetate (3* 30mL) extraction, drying of the organic phase, spin drying,Crude column chromatography (n-heptane: ethyl acetate = 1:5),The product was obtained in 3 (2 g). |
- 2
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[ 173841-06-0 ]
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[ 1609393-90-9 ]
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methyl 3-(3-amino-2-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxylate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 29.4% |
With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In 1,4-dioxane; water at 125℃; for 1h; Inert atmosphere; |
455.1 Step 1 :
A stirred mixture of methyl 3-chloro-1-methyl-1H-pyrazole-5-carboxylate (200 mg, 1.146 mmol), 2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (499 mg, 2.005 mmol) and l,r-bis(di-tert-butylphosphino)ferrocene palladium dichloride (37.3 mg, 0.057 mmol) in Dioxane (6 ml) was degassed by bubbling nitrogen through the mixture for 5 minutes. 2M K3PO4 (aq) (1.718 ml, 3.44 mmol) was quickly added and the reaction mixture heated at 125 °C for 1Hr. The reaction mixture was partitioned between EtOAc (30 ml) and water (30 ml). The organic layer was washed with brine (30 ml), dried (Na2S04) and concentrated to afford a brown oil that was chromatographed on a 24 gm ISCO silica gel cartridge, eluting with a 0-50%EtO Ac/Hexanes gradient. The pure fractions were concentrated to afford methyl 3-(3-amino-2-methoxyphenyl)-1-ethyl-1H-pyrazole-5-carboxylate (89 mg, 0.337 mmol, 29.4 % yield) as a tan solid. LCMS m/z 262.2 (M+H)+; HPLC fe 0.65 min (analytical HPLC Method A). |
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