Alternatived Products of [ 17402-80-1 ]
Product Details of [ 17402-80-1 ]
| CAS No. : | 17402-80-1 |
MDL No. : | MFCD00456545 |
| Formula : |
C8H5NO2S
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : | 179.20 |
Pubchem ID : | - |
| Synonyms : |
|
Application In Synthesis of [ 17402-80-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 17402-80-1 ]
- Downstream synthetic route of [ 17402-80-1 ]
- 1
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[ 17402-80-1 ]
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[ 17402-83-4 ]
- 2
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[ 17402-80-1 ]
-
[ 2510-03-4 ]
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C21H14N2S
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 72% |
With cetyltrimethylammonim bromide In water at 20℃; for 30h; |
Example 1
General procedure: Add benzo in order to the reaction tubeSix-membered ring dicyanoolefin1a (0.10 mmol),2-nitrobenzofuran 2a (0.12 mmol), adding Cs2CO3 (1 eq, 0.1 mmol),Cetyltrimethylammonium bromide CTAB (5mol%, 0.005mmol) and 1.0mL of water,Stir at room temperature for 24h. TLC detects the basic reaction is complete. The reaction solution is filtered to obtain a filter cake.After dissolving in a small amount of dichloromethane, the sample was loaded and subjected to column chromatography (eluent: V (petroleum ether):V (ethyl acetate) = 5: 1) to obtain compound 4aa as a white solid,Melting point: 182.3-183.1 ° C; yield 90% |
| 72% |
With cetyltrimethylammonim bromide; caesium carbonate In water at 20℃; for 30h; |
4.2. General procedure for the synthesis of compounds 3, 5, 7, 9
General procedure: To a solution of 1 or 4 or 6 or 8 (0.12 mmol) and 2 (0.10 mmol) in H2O (1 mL) was added Cs2CO3 (32.5 mg, 0.10 mmol) and CTAB(2.0 mg, 5 mol%). The mixture was further stirred at room temperature for the indicated time. Once starting material was consumed (monitored by TLC), the mixture was filtered and the residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate 8:1 to 3:1) to afford the corresponding product. |
Reference：
[1]Current Patent Assignee: ZUNYI MEDICAL AND PHARMACEUTICAL COLLEGE - CN110724120, 2020, A
Location in patent: Paragraph 0031-0032; 0040; 0044-0046
[2]Chen, Yong-Zheng; Quan, Bao-Xue; Yuan, Wei-Cheng; Zhang, Ming-Liang; Zhang, Xiao-Mei; Zhao, Jian-Qiang; Zhuo, Jun-Rui
[Tetrahedron, 2020]
- 3
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[ 2510-01-2 ]
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[ 17402-80-1 ]
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6-amino-12H-benzo[b]fluoreno[2,1-d]thiophene-5-carbonitrile
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 72% |
With cetyltrimethylammonim bromide; caesium carbonate In water at 20℃; for 24h; |
4.2. General procedure for the synthesis of compounds 3, 5, 7, 9
General procedure: To a solution of 1 or 4 or 6 or 8 (0.12 mmol) and 2 (0.10 mmol) in H2O (1 mL) was added Cs2CO3 (32.5 mg, 0.10 mmol) and CTAB(2.0 mg, 5 mol%). The mixture was further stirred at room temperature for the indicated time. Once starting material was consumed (monitored by TLC), the mixture was filtered and the residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate 8:1 to 3:1) to afford the corresponding product. |
- 4
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[ 17402-80-1 ]
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[ 573-97-7 ]
-
C18H9BrOS
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 68% |
With potassium carbonate In ethanol at 80℃; for 24h; |
3 Synthesis of intermediate 10:
Take 100mL double-necked round-bottom flask, connect spherical condensing tubes, add raw material 12 (6g, 0.013mol) respectively and take intermediate 9 (8g, 0.044mol) and add it to a 50mL ethanol suspension containing 78g K2CO3, stir the reaction at 80 °C for 24 hours. After the solvent was removed, the residue was purified by column chromatography to give the intermediate 10 (5.65g, 68%). |
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