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Chemical Structure| 174267-71-1 Chemical Structure| 174267-71-1

Structure of DTPA-tetra (t-Bu ester)
CAS No.: 174267-71-1

Chemical Structure| 174267-71-1

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Product Details of [ 174267-71-1 ]

CAS No. :174267-71-1
Formula : C30H55N3O10
M.W : 617.77
SMILES Code : O=C(O)CN(CCN(CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O
MDL No. :MFCD28291825

Safety of [ 174267-71-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 174267-71-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 174267-71-1 ]

[ 174267-71-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57260-73-8 ]
  • [ 117-78-2 ]
  • [ 174267-71-1 ]
  • C31H35N5O12 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Will 200mg (0.70mmol) rhein,148 mg (0.77 mmol) of EDC was added to 100 mL of dichloromethane and stirred for 30 min at room temperature.Then add 88mg (0.77mmol) NHS,Reaction at room temperature for 24h until the reaction system is clear100 muL of N-Boc-ethylenediamine was added dropwise to the reaction solution.Stir at room temperature for 24h,Filtered to give a yellow solid,Wash with methanol to give pure Intermediate 1. 200 mg (0.47 mmol) of Intermediate 1 was added to 15 ml of dichloromethane/trifluoroacetic acid (10:1) and reacted at room temperature for 12 h. The solvent was evaporated under reduced pressure to give Intermediate 2.421 mg (0.74 mmol) of DOTA-tris(tBu)ester,280 mg (0.74 mmol) HBTU was added to 50 mL acetonitrile,Then add 100muL DIPEA,Room temperature reaction for 30min,Then, 241 mg (0.74 mmol) of Intermediate 2 was added to the reaction system.Room temperature reaction 24h.The solvent was removed under reduced pressure to give crude product.Purification by silica gel column gave Intermediate 3.200 mg (0.23 mmol) of intermediate 3 was added to 20 mL of dichloromethane/trifluoroacetic acid (1:1) and reacted at room temperature for 24 h.The solvent was removed under reduced pressure to give ligand 1.200 mg (0.28 mmol) of Ligand 1,104mg (0.28mmol)GADOLINIUM(III) CHLORIDE HEXAHYDRATE IN5mL water,Adjust pH to 6-7 with 1M NaOH and react at room temperature for 24h.Evaporate the solvent under reduced pressure.
 

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