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Chemical Structure| 17448-14-5 Chemical Structure| 17448-14-5

Structure of 17448-14-5

Chemical Structure| 17448-14-5

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Product Details of [ 17448-14-5 ]

CAS No. :17448-14-5
Formula : C15H13NO2
M.W : 239.27
SMILES Code : O=C1N(CC2=CC=CC=C2)C(O)C3=C1C=CC=C3
MDL No. :MFCD02216044

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Application In Synthesis of [ 17448-14-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17448-14-5 ]

[ 17448-14-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 23069-99-0 ]
  • [ 17448-14-5 ]
  • 2-benzyl-3-(phenethylamino)isoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With copper(l) iodide; phenylboronic acid; In 1-methyl-pyrrolidin-2-one; at 100℃; for 23h; General procedure: To an oven-dried test tube charged with a mixture of 2-benzyl-3-hydroxyisoindolin-1-one 5a (100 mg, 1 mmol,),N,Ndimethylformamide (DMF, 30 mg, 1 mmol), copperiodide (7.9 mg, 0.1 mmol), phenylboronic acid (50 mg, 1mmol), N-methylpyrrolidinone (1 mL) were added. The testtube with the resulting inhomogeneous solution was kept in apre-heated (100 C) oil-bath and the contents were stirred.The progress of the reaction was periodically checked byTLC for its completion. After the disappearance of the reactantsthe reaction mixture was cooled to rt and then dilutedwith dichloromethane (DCM, 20 mL) and water (20 mL).The aqueous layer was extracted with (DCM, 20 mL). Theorganic layersweremixed andwashed withwater (2×20 mL)and brine (1 × 10 mL) sequentially. The organic layer wasdried over Na2SO4. Removal of DCM by under reducedpressure resulted in a crude product which was purified bycolumn chromatography (silica gel, gradient elution withincreasing volume of EtOAc in hexanes) to yield pure 2-benzyl-3-(dimethylamino)isoindolin-1-one as yellow solid.
 

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