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[ CAS No. 175135-62-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 175135-62-3
Chemical Structure| 175135-62-3
Structure of 175135-62-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 175135-62-3 ]

CAS No. :175135-62-3 MDL No. :MFCD00067800
Formula : C11H6F2N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 252.17 Pubchem ID :-
Synonyms :

Safety of [ 175135-62-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P321-P322-P330-P332+P313-P337+P313-P362-P363-P403+P233-P403+P235-P405-P501 UN#:N/A
Hazard Statements:H302-H312-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 175135-62-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 175135-62-3 ]

[ 175135-62-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 175135-62-3 ]
  • [ 175135-63-4 ]
YieldReaction ConditionsOperation in experiment
80% With sodium dithionite; water In tetrahydrofuran at 20℃; for 2.5h;
37% With sodium sulfate In tetrahydrofuran; water at 20℃; for 2.5h; 4.6.2.9 2-(2,4-difluorophenoxy)pyridin-3-amine (4) Compound 4 was synthesized according to published conditions.63 2-(2,4-difluorophenoxy)-3-nitropyridine (150mg, 0.60mmol, 1eq) was dissolved in 4mL THF. A solution of sodium dithionite (Na2S2O4, 1.5g, 8.6mmol, 14.5eq) in 14.6mL H2O was added, and the mixture was allowed to stir at room temperature for 2.5h at which point TLC in 80:20 hexanes:EtOAc indicated completion. The reaction mixture was quenched with saturated NaHCO3 (10mL) and extracted with CH2Cl2 (3×15mL), dried with brine (30mL) and Na2SO4. Evaporation of solvent under reduced pressure gave pure product 4(as a white solid which was used without further purification (50mg, 37%; a repeat reaction on a larger scale gave 156mg, 30%): 1H NMR (400MHz, d6-DMSO): δ 7.40,7.29 (m, 2H), 7.12 (dd, J=4.70, 1.17, 1H), 7.11,6.82 (m, 2H), 8.20 (dd, J=7.82, 4.70, 1H), 5.29 (s, 1H).
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