Alternatived Products of [ 175277-91-5 ]
Product Details of [ 175277-91-5 ]
CAS No. : | 175277-91-5 |
MDL No. : | MFCD00084879 |
Formula : |
C10H13F3N2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
218.22
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 175277-91-5 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 175277-91-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 175277-91-5 ]
Yield | Reaction Conditions | Operation in experiment |
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15.24 (24)
(24) 3-Amino-4-(isopropylamino)benzotrifluoride NMR(DMSO-d6, δ): 1.17(6H, d, J=6.5 Hz), 3.62(1H, m), 4.74(1H, d, J=7.5 Hz), 4.94(2H, s), 6.48(1H, d, J=8.5 Hz), 6.79(1H, s), 6.79(1H, d, J=8.5 Hz). MS m/z: 219(M++1). |
- 2
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[ 175277-90-4 ]
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[ 175277-91-5 ]
Yield | Reaction Conditions | Operation in experiment |
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With hydrogen In ethyl acetate at 20℃; for 1.5h; |
209
A mixture of 5.46 g of N-isopropyl-2-nitro-4- trifluoromethylaniline, 30 ml of ethyl acetate and 5% palladium charcoal (catalytic amount) was stirred for 1.5 hours at room temperature under a hydrogen atmosphere of about 1 atm. The reaction mixture was filtrated through Celite (registered trademark) . The filtrate was washed with water, dried over sodium sulfate, then, concentrated under reduced pressure, to obtain 4.35 g of Nl-isopropyl-4-trifluoromethylbenzene- 1, 2-diamine.1H-NMR (CDCl3) δ: 7.08 (dd, IH), 6.93 (d, IH), 6.63 (d, IH), 3.65 (brs, IH), 3.54 (brs, IH), 3.31 (br s, 2H), 1.25 (d, 6H) . |
- 3
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[ 175277-91-5 ]
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sodium hydroxy-pyridin-4-yl-methanesulfonate
[ No CAS ]
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[ 1254166-32-9 ]
Yield | Reaction Conditions | Operation in experiment |
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In N,N-dimethyl-formamide at 150℃; for 1h; |
219
Production Example 219; A mixture of 0.44 g of Nl-isopropyl-4- trifluoromethylbenzene-1, 2-diamine, 0.51 g of isonicotinealdehyde-bisulfite adduct and 4 ml of N, N- dimethylformamide was stirred for 1 hour at 150°C. The reaction mixture was allowed to cool to room temperature, and water was poured into this, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate, then, concentrated under reduced pressure to obtain a solid residue. The residue was washed with hexane, to obtain 0.50 g of l-isopropyl-2- (pyridin-4-yl- ) -5- trifluoromethyl-lH-benziinidazole (hereinafter, referred to as present active compound 219) . Present active compound 219 1H-NMR (CDCl3) δ: 8.84 (dd, 2H), 8 .12 (d, IH), 7.74 (d, IH), 7.58-7.55 (m, 3H), 4.88-4.78 (m, IH) , 1.70 (d, 6H) . |