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Chemical Structure| 175422-05-6 Chemical Structure| 175422-05-6

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Chemical Structure| 175422-05-6

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Product Details of [ 175422-05-6 ]

CAS No. :175422-05-6
Formula : C13H12BrNO2
M.W : 294.14
SMILES Code : COC1=CC(OCC2=CC=CC=C2)=NC(Br)=C1
MDL No. :MFCD17014972

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 175422-05-6 ]

[ 175422-05-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 175422-05-6 ]
  • [ 827-99-6 ]
  • [ 175421-75-7 ]
YieldReaction ConditionsOperation in experiment
With CuI; In N-methyl-acetamide; mineral oil; (3) Synthesis of 2-benzyloxy-4-methoxy-6-(meta-trifluoromethoxyphenoxy)pyridine from the Intermediate To a dimethylformamide solution containing meta-trifluoromethoxy phenol (0.52 g, 0.0013*2.2 mol), sodium hydride (0.11 g (ca.60percent in mineral oil), 0.0013*2.1 mol) was added. Then, 2-benzyloxy-6-bromo-4-methoxypyridine (0.39 g, 0.0013 mol) and CuI (0.06 g, 0.0013*0.5 mol) were successively added thereto and the resultant solution was stirred for about 21 hours at the temperature of about 110° to 120° C. The reaction solution was partitioned between ethyl acetate and aqueous saturated sodium hydrogen carbonate. The obtained organic layer was washed with aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and thereafter concentrated. The concentrate was purified on a silica gel column and the starting material which was difficult to separate was distilled off by using a tubular oven, whereby the end product was obtained. Yield: 0.24 g (46percent). Oily product. 1 H-NMR (60 MHz, CDCl3, delta): 3.67(3H, s), 5.04(2H, s), 5.93(2H, s), 6.7-7.4(9H, complex).
 

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