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Chemical Structure| 178970-86-0 Chemical Structure| 178970-86-0

Structure of 178970-86-0

Chemical Structure| 178970-86-0

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Product Details of [ 178970-86-0 ]

CAS No. :178970-86-0
Formula : C8H7NO2S
M.W : 181.21
SMILES Code : O=C1OCC(C=C(C)N2)=C1C2=S

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Application In Synthesis of [ 178970-86-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 178970-86-0 ]

[ 178970-86-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 57684-71-6 ]
  • [ 178970-86-0 ]
  • 4-[(isoxazol-3-ylmethyl)sulfanyl]-6-methylfuro[3,4-c]pyridin-3(1H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With potassium hydroxide; In water; N,N-dimethyl-formamide;Reflux; General procedure: 10% aqueous KOH (3.1 ml, 5.6 mmol) was added to 6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3-one (4) (1.0 g, 5.6 mmol) in DMF (20 ml). The reaction mixture was heated (40-60C) until homogenous solution formed, and an equimolar amount of the corresponding alkylating reagent was added. The mixture was heated under reflux with stirring for 3-8 h, monitoring the progress of the reaction by TLC. After cooling in an ice bath, the crystalline product was filtered off, washed with H2O, and recrystallized from EtOH.
  • 2
  • [ 108499-32-7 ]
  • [ 178970-86-0 ]
  • methyl 5-[(6-methyl-3-oxo-1,3-dihydrofuro[3,4-c]pyridin-4-yl)sulfanyl]methyl}thiophene-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With potassium hydroxide; In water; N,N-dimethyl-formamide;Reflux; General procedure: 10% aqueous KOH (3.1 ml, 5.6 mmol) was added to 6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3-one (4) (1.0 g, 5.6 mmol) in DMF (20 ml). The reaction mixture was heated (40-60C) until homogenous solution formed, and an equimolar amount of the corresponding alkylating reagent was added. The mixture was heated under reflux with stirring for 3-8 h, monitoring the progress of the reaction by TLC. After cooling in an ice bath, the crystalline product was filtered off, washed with H2O, and recrystallized from EtOH.
 

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