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Chemical Structure| 179900-21-1 Chemical Structure| 179900-21-1

Structure of 179900-21-1

Chemical Structure| 179900-21-1

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Product Details of [ 179900-21-1 ]

CAS No. :179900-21-1
Formula : C10H11FN2O3
M.W : 226.20
SMILES Code : O=[N+](C1=C(F)C=CC=C1N2CCOCC2)[O-]
MDL No. :MFCD13689255

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Application In Synthesis of [ 179900-21-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 179900-21-1 ]

[ 179900-21-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 19064-24-5 ]
  • [ 179900-21-1 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In DMF (N,N-dimethyl-formamide); for 18h; To a 0.1 M DMF solution of 1, 3-difluoro-2-nitrobenzene was added Et3N (2 equivalents) followed by an amine (1 equivalent), e. g. morpholine. The mixture was stirred for 18 hours and then diluted with water and extracted with ethyl acetate. LC/MS M/Z 227.2 (MH+), RT2. 522 minutes. The combined organic layers were dried over MGS04, filtered, and concentrated. Ammonia was condensed into a pressure vessel containing the crude product. The pressure vessel was sealed and heated to 100 C (over 400 psi). After 72 hours, the pressure vessel was allowed to cool and the ammonia was evaporated to provide a reddish solid. The nitroamine was reduced as in Method 1 to provide the crude product which was used without FURTHERPURIFICATION. LC/MS M/Z194. 1 (MH+), RT1. 199 minutes.
 

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