Alternatived Products of [ 1800022-02-9 ]
Product Details of [ 1800022-02-9 ]
| CAS No. : | 1800022-02-9 |
MDL No. : | MFCD32012091 |
| Formula : |
C28H18N2
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | HTWMXCZFSCJBEX-UHFFFAOYSA-N |
| M.W : |
382.46
|
Pubchem ID : | 118204127 |
| Synonyms : |
|
Safety of [ 1800022-02-9 ]
Application In Synthesis of [ 1800022-02-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1800022-02-9 ]
- 1
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[ 1800022-01-8 ]
-
[ 1800022-02-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 88% |
With palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate In toluene at 120℃; for 5h; |
1.5 5) Preparation of compound 1-5
Compound 1-4 (26.0 g, 69.84 mmol), Pd(OAc)2 (0.6 g, 2.79 mmol), Cs2CO3 (45.0 g, 137.49 mmol), tricyclohexylphosphine tetrafluoroborate (PCy3HBF4) (1.7 g, 4.58 mmol), and toluene (300.0 mL) were dissolved in a flask and the mixture was refluxed at 120 °C for 5 hrs. After completing the reaction, the organic layer was extracted with EA and dried by removing the remaining moisture with MgSO4. The residue was separated via column chromatography to obtain compound 1-5 (15.0 g, 88 %). |
- 2
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[ 591-18-4 ]
-
[ 1800022-02-9 ]
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[ 1800022-03-0 ]
| Yield | Reaction Conditions | Operation in experiment |
| 65% |
With potassium phosphate; copper(l) iodide; ethylenediamine In toluene at 120℃; for 5h; |
1.6 6) Preparation of compound 1-6
Compound 1-5 (14.0 g, 36.60 mmol), 1-bromo-3-iodobenzene (15.0 g, 54.91 mmol), CuT (3.5 g, 18.30 mmol), K3P04 (23.0 g, 109.8 mmol), EDA (3.0 mL, 36.60 mmol), and toluene (183.0 mL) were dissolved in a flask and the mixture was refluxed at 120°C for 5 hrs. After completing the reaction, the organic layer was extracted with EA and dried by removing the remaining moisture with MgSO4. The residue was separated via column chromatography to obtain compound 1-6 (12.4 g, 65 %). |
| 64% |
With potassium phosphate; copper(l) iodide; ethylenediamine In toluene for 24h; |
13 Synthesis of compound 11
The 7-phenyl-7,9-dihydrobenzo[g]indolo[2,3-b]carbazole (10g, 26.14mmol), 1-bromo-3-iodobenzene (14.8g, 52.29mmol) ), CuI (2.5 g, 13.07 mmol), EDA (1.57 g, 26.14 mmol) and K3PO4 (13.8 g, 65.36 mmol) were added to 130 mL of toluene, and the mixture was stirred for one day. After the reaction was completed, the reaction product was cooled to room temperature, and extracted with distilled water and MeOH. The extracted product was separated by column chromatography (using MC/Hex) to obtain compound 11 (9 g, yield: 64%). |
- 3
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[ 223463-13-6 ]
-
[ 1800022-02-9 ]
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[ 2049026-09-5 ]
| Yield | Reaction Conditions | Operation in experiment |
| 87% |
With potassium phosphate; copper(l) iodide; ethylenediamine In toluene at 120℃; |
9 Preparation of compound 9-2
Preparation of compound 9-2[279]After introducing compound 9-1 (7 g, 18 mmol), 2-iodo-5-bromopyridine (10.4 g, 37 mmol), CuI (1.74 g, 9 mmol), EDA (1.1 g, 18 mmol), and K3PO4(11.7 g, 55 mmol) into a flask, toluene 100 mL was added thereto to dissolve the mixture, and the mixture was stirred under reflux at 120°C. After the reaction is completed, the reactant was cooled at room temperature, filtered through celite, and an organic layer was extracted with ethyl acetate. The remaining moisture was removed with magnesium sulfate and dried. The remaining product was then purified with column chromatography to obtain compound 9-2 (8.6 g, yield: 87%). |
- 4
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[ 60631-83-6 ]
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7-phenyl-7,9-dihydrobenzo[g]indolo[2,3-b]carbazole
[ No CAS ]
-
C46H30N2
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 16.3% |
With copper; potassium carbonate In 1,2-dichloro-benzene at 230℃; for 12h; |
12 Example 12: preparation of compound H1 -6
The 7-phenyl-7,9-dihydrobenzo[g]indolo[2,3-b]carbazole (5.0g, 13mmol), 4'-bromo-1,1': 3', 1 "-Terphenyl (6.06g, 20mmol), Cu powder (1.307g, 0.65mmol) and K2CO3 (3.4g, 26mmol) were added to 60mL of o-dichlorobenzene (o-DCB) in the flask, and the mixture was Stir for 12 hours at 230°C under reflux. After the reaction was completed, the organic layer was extracted with EA, dried with MgSO4 and separated by column chromatography. Then, MeOH was added to the separated product, and the resulting solid was added to the It was filtered under reduced pressure to obtain compound H1-6 (1.3 g, yield: 16.3%). |
- 5
-
[ 2740503-34-6 ]
-
[ 1800022-02-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 77% |
With triphenylphosphine In 1,2-dichloro-benzene at 175℃; for 36h; Inert atmosphere; |
Synthesis of intermediate a1
Intermediate a1-3 (26.0g; 62.7mmol), triphenylphosphine (41.1g; 156.8mmol), and o-dichlorobenzene (250mL) were added to the flask, heated to 175°C under nitrogen protection, and stirred for 36 hours; After the temperature is lowered to room temperature, the reaction solution is washed with water for liquid separation, the organic phase is washed with water and then dried with anhydrous magnesium sulfate, and the solvent is removed under high temperature and reduced pressure to obtain a crude product;The crude product was purified by silica gel column chromatography using a dichloromethane/n-heptane system to obtain a white solid intermediate a1 (18.5 g, yield 77%). |
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